×

People

Prof. Vincent CT MOK

The Chinese University of Hong Kong

Head of Division of Neurology (Academic Affairs)
Endowed Mok Hing Yiu Professor of Medicine
Assistant Dean (Student Affairs, Admission), Faculty of Medicine
Programme Co-Director, MSc Programme in Stroke and Clinical Neurosciences (MCNS)
Director, Therese Pei Fong Chow Research Centre for Prevention of Dementia
Director, Margaret K.L. Cheung Research Centre for Management of Parkinsonism
Executive Committee Member, Chow Yuk Ho Technology Center for Innovative Medicine
Prince of Wales Hospital

Specialist in Neurology
Honorary Consultant, Department of Medicine and Therapeutics
Academic and Professional Qualifications
MBBS (Syd), MD (CUHK), FRCP (Edin), FHKAM (Medicine), FHKCP, MRCP (UK)
Contact Information

Tel.: (852) 2558 7122

Biography

Prof. Vincent Mok's research aims to understand mechanisms of dementia and to investigate strategies that may help to prevent dementia. He is the first to report the association of cerebral small vessel disease (CSVD) and cognitive impairment in Asia and the first to report the community prevalence of CSVD among Asians (Chinese). Such findings have significantly increased the awareness that strategies targeting CSVD (e.g. blood pressure lowering) can help to prevent dementia in this region, where the burden of dementia is particularly huge. Prof. Mok conducted one of the largest single-centre studies investigating the prevalence and mechanisms of early and delayed cognitive decline in the context of stroke and found that concurrent presence of amyloid plaques as detected by in-vivo amyloid PET imaging and CSVD are important factors associated with early and delayed cognitive decline after stroke, respectively. Such findings provide a road map of how to prevent vascular cognitive impairment. Prof. Mok, along with Dr Adrian Wong (Clinical Psychologist) validated the Hong Kong-Montreal Cognitive Assessment (HK-MoCA) and developed norms for HK-MoCA performance according to age and education. HK-MoCA is currently the commonest brief cognitive assessment used for the assessment of cognitive function and the detection of mild cognitive impairment in HK.

Prof. Mok has been involved in the validation and clinical application of a novel Machine-Learning MRI-based Index, which was developed by a spin-off company of the Chinese University of Hong Kong (CUHK), for the detection of early Alzheimer’s disease. Such technology provides an easy screening method for early Alzheimer’s disease among subjects with mild cognitive impairment. Moreover, he also specializes in Parkinson's disease and was one of the pioneers of developing Deep Brain Stimulation programme in Asia for the treatment of Parkinson’s disease.

He received the Higher Education Outstanding Scientific Research Output Award (Science & Technology) in Natural Sciences (1st Class) from the Ministry of Education, People's Republic of China in 2011 for his research in cerebrovascular disease, Outstanding Fellow Award from the Faculty of Medicine of CUHK for his exceptional academic leadership in areas of research, education and service in 2016, Endowment as Mok Hing Yiu Professor of Medicine by CUHK in 2017, and the Excellent Research Award from the Food and Health Bureau of the Hong Kong Special Administrative Region for his research in vascular cognitive impairment in 2017. He received 7 times Teacher of the Year Award and the Master Teacher Award from the Faculty from the Faculty of Medicine, CUHK.

Prof. Mok has authored more than 300 publications in peer-reviewed international journals (with book chapters), with publications at Lancet, JAMA, Lancet Neurology, Nature Reviews Neurology, Alzheimer’s & Dementia, JAMA Neurology, JAMA Psychiatry, Journal of Neurology, Neurosurgery and Psychiatry (JNNP), Annals of Neurology, Neurology and Stroke.

Prof. Vincent CT MOK

The Chinese University of Hong Kong

Head of Division of Neurology (Academic Affairs)
Endowed Mok Hing Yiu Professor of Medicine
Assistant Dean (Student Affairs, Admission), Faculty of Medicine
Programme Co-Director, MSc Programme in Stroke and Clinical Neurosciences (MCNS)
Director, Therese Pei Fong Chow Research Centre for Prevention of Dementia
Director, Margaret K.L. Cheung Research Centre for Management of Parkinsonism
Executive Committee Member, Chow Yuk Ho Technology Center for Innovative Medicine
Prince of Wales Hospital

Specialist in Neurology
Honorary Consultant, Department of Medicine and Therapeutics
Research Interests
  • Vascular Cognitive Impairment, Poststroke Dementia, Mixed Dementia
  • Cerebral Small Vessel Disease
  • Multi-modal Brain and Retinal Imaging for stroke and cognitive impairment
  • Parkinson's disease - premotor stage, genetics, neuroimaging, and Deep Brain Stimulation
Honorary Appointments in Other Professional Activities
  • Member of the Expert Committee on Clinical Events Assessment Following COVID-19 Immunisation, The Government of the Hong Kong Special Administrative Region, 2021 - present
  • Chair of the Local Organizing Committee of the 9th International Meeting of the International Society of Vascular Behavioural and Cognitive Disorders, HKSAR, 2018
  • Co-Chair of the Congress Scientific Program Committee of 2018 International Congress of the International Parkinson's Disease and Movement Disorder Society, HKSAR, 2018
  • Secretary of the Neurology Specialty Board, Hong Kong College of Physicians, 2018 – present
  • Advisory Council Member of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 – 2020
  • Vice-Chair and Hong Kong Representative of the China Greater Bay Guang Zhou-Hong Kong-Macau Neurology Alliance, 2018
  • Hong Kong Representative of the World Federation of Neurology, 2012 – 2021
  • Executive Committee Member of the International Society of Vascular Behavioral and Cognitive Disorders, 2011 –Present
  • Honorary Treasurer of the Asian Society Against Dementia, 2011 – Present
  • Chair of the Scientific Program Committee of the 2017 Asia Pacific Stroke Conference, Nanjing China, 2017
  • President of the Chinese Dementia Research Association, 2015 – 2016
  • Member of Working Group of European Union-Joint Programme Neurodegenerative Disease (EU-JPND) Research in Longitudinal Cohorts, 2015
  • Member of the Stroke Progress Review Group in Vascular Cognitive Member of the Stroke Progress Review Group in Vascular Cognitive Impairment of the National Institute of Neurological Diseases and Stroke of United States of America, 2012
  • President of the Hong Kong Movement Disorder Society, 2011 – 2013
Awards
  • Excellent Research Award, Food & Health Bureau, HKSAR (2017)
  • Outstanding Fellow of Faculty of Medicine, CUHK (2016)
  • Ministry of Education Higher Education Outstanding Scientific Research Output Award - First-class Award in Natural Sciences (2011 )
  • Master Teacher Award, CUHK (2012)
  • Teacher of the Year Award for 7 times, CUHK (2005-2012)
Selected Publications