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Publications

2024

Fish-on-Chips: unveiling neural processing of chemicals in small animals through precise fluidic control

Sy SKH, Ko H
Neural Regen Res. 2024 Nov 1;19(11):2351-2353. doi: 10.4103/1673-5374.392876. Epub 2024 Jan 8. PMID: 38526270.

Geometry of Terminal Internal Carotid Artery Bifurcation May Be Associated With Middle Cerebral Artery Plaque Ulceration: A Three-Dimensional Rotational Angiography Study

Leng X, Ip BYM, Ma SH, Lui WT, Ip VHL, Fan FSY, Leung H, Mok VCT, Yu SCH, Leung TW
J Stroke. 2024 Aug 30. doi: 10.5853/jos.2024.00129. Epub ahead of print. PMID: 39205534.

Development and External Validation of a Motor Intention-Integrated Prediction Model for Upper Extremity Motor Recovery After Intention-Driven Robotic Hand Training for Chronic Stroke

Hu C, Ti CHE, Shi X, Yuan K, Leung TWH, Tong RK
Arch Phys Med Rehabil. 2024 Aug 30:S0003-9993(24)01194-8. doi: 10.1016/j.apmr.2024.08.015. Epub ahead of print. PMID: 39218244.

Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends

Chan VTT, Ran AR, Wagner SK, Hui HYH, Hu X, Ko H, Fekrat S, Wang Y, Lee CS, Young AL, Tham CC, Tham YC, Keane PA, Milea D, Chen C, Wong TY, Mok VCT, Cheung CY
Prog Retin Eye Res. 2024 Aug 22;103:101290. doi: 10.1016/j.preteyeres.2024.101290. Epub ahead of print. PMID: 39173942.

Lipid control and stroke risk in atrial fibrillation patients treated with direct oral anticoagulants and statins

Ip B, Yip T, Hung T, Yam TF, Yeung C, Ko H, Wong G, Leng X, Mok V, Soo Y, Seiffge D, Shoamanesh A, Leung T
Eur Stroke J. 2024 Aug 19:23969873241272530. doi: 10.1177/23969873241272530. Epub ahead of print. PMID: 39158514.

Lactone-to-Lactam Editing Alters the Pharmacology of Bilobalide

Jiang X, He X, Wong J, Scheeff S, Hau SC, Wong TH, Qin Y, Fan CH, Ma B, Chung NL, Huang J, Zhao J, Yan Y, Xiao M, Song X, Hui TKC, Zuo Z, Wu WK, Ko H, Chow KH, Ng BW.
JACS Au. 2024 Jul 16;4(9):3537-3546. doi: 10.1021/jacsau.4c00416. PMID: 39328759; PMCID: PMC11423332.

Predictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial

Lu H, Li J, Chan SSM, Ma SL, Mok VCT, Shi L, Mak AD, Lam LCW
Dialogues Clin Neurosci. 2024;26(1):38-52. doi: 10.1080/19585969.2024.2373075. Epub 2024 Jul 4. PMID: 38963341; PMCID: PMC11225634

Visuospatial dysfunction predicts dementia-first phenoconversion in isolated REM sleep behaviour disorder

Wang J, Huang B, Zhou L, Tang S, Feng H, Chan JWY, Chau SWH, Zhang J, Li SX, Mok V, Wing YK, Liu Y
J Neurol Neurosurg Psychiatry. 2024 Jun 26:jnnp-2024-333865. doi: 10.1136/jnnp-2024-333865. Epub ahead of print. PMID: 38925912

Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis

Chau SWH, Chue TM, Chan RNY, Lai YL, Wong PWC, Li SX, Liu Y, Chan JWY, Chan PK, Lai CKC, Leung TWH, Wing YK
Transl Psychiatry. 2024 Jun 19;14(1):261. doi: 10.1038/s41398-024-02978-w. PMID: 38898009; PMCID: PMC11187160

APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Ning Z, Liu Y, Wan M, Zuo Y, Chen S, Shi Z, Xu Y, Li H, Ko H, Zhang J, Xiao S, Guo D, Tang Y
Cell Mol Biol Lett. 2024 Jun 12;29(1):87. doi: 10.1186/s11658-024-00600-x. PMID: 38867189; PMCID: PMC11170814.

Task-Oriented Training by a Personalized Electromyography-Driven Soft Robotic Hand in Chronic Stroke: A Randomized Controlled Trial

Shi XQ, Ti CE, Lu HY, Hu CP, Xie DS, Yuan K, Heung HL, Leung TW, Li Z, Tong RK
Neurorehabil Neural Repair. 2024 May 29:15459683241257519. doi: 10.1177/15459683241257519. Epub ahead of print. PMID: 38812378.

Clinical implications of haemodynamics in symptomatic intracranial atherosclerotic stenosis by computational fluid dynamics modelling: a systematic review

Liu Y, Li S, Liu H, Tian X, Liu Y, Li Z, Leung TW, Leng X
Stroke Vasc Neurol. 2024 May 28:svn-2024-003202. doi: 10.1136/svn-2024-003202. Epub ahead of print. PMID: 38806205.

Stroke

Hilkens NA, Casolla B, Leung TW, de Leeuw FE
Lancet. 2024 May 14:S0140-6736(24)00642-1. doi: 10.1016/S0140-6736(24)00642-1. Epub ahead of print. PMID: 38759664.

Stroke in Asia

Tan KS, Pandian JD, Liu L, Toyoda K, Leung TWH, Uchiyama S, Kuroda S, Suwanwela NC, Aaron S, Chang HM, Venketasubramanian N
Cerebrovasc Dis Extra. 2024;14(1):58-75. doi: 10.1159/000538928. Epub 2024 Apr 26. PMID: 38657577.

Impact of renal function variability on long-term prognosis in ischemic stroke patients with atrial fibrillation

Wang X, Sin CF, Teo KC, Leung WCY, Wong YK, Liu RKC, Fok JW, Ip BY, Kwan HH, Lee TC, Sheng B, Yip EK, Yap DYH, Luo H, Lau KK
Front Neurol. 2024 Apr 22;15:1294022. doi: 10.3389/fneur.2024.1294022. PMID: 38711560; PMCID: PMC11071668.

Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial

Zheng L, Nie X, Wang M, Liu X, Duan W, Zhang Z, Liu J, Wei Y, Wen M, Yang Z, Leung TW, Ma G, Huo X, Pan Y, Nguyen TN, Leng X, Miao Z, Liu L; ANGEL-ASPECT Investigators
EClinicalMedicine. 2024 Apr 12;72:102595. doi: 10.1016/j.eclinm.2024.102595. PMID: 38638180; PMCID: PMC11024914.

Current and Future Treatments of Vascular Cognitive Impairment

Ip BYM, Ko H, Lam BYK, Au LWC, Lau AYL, Huang J, Kwok AJ, Leng X, Cai Y, Leung TWH, Mok VCT
Stroke. 2024 Apr;55(4):822-839. doi: 10.1161/STROKEAHA.123.044174. Epub 2024 Mar 25.

Case Report: Taxifolin for neurosurgery-associated early-onset cerebral amyloid angiopathy

Choi MCY, Law THP, Chen S, Cheung WSK, Yim C, Ng OKS, Au LWC, Mok VCT, Woo PYM
Front Neurol. 2024 Mar 19;15:1360705. doi: 10.3389/fneur.2024.1360705. PMID: 38566852; PMCID: PMC10985332.

Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

Xie J, Cheng J, Ko H, Tang Y
EMBO Mol Med. 2024 Mar 11. doi: 10.1038/s44321-024-00046-w. PMID: 38467840.

Behavioral disinhibition in stroke

Tang WK, Hui E, Leung TWH
Front Neurol. 2024 Mar 4;15:1345756. doi: 10.3389/fneur.2024.1345756

Neurological complications of modern radiotherapy for head and neck cancer

Chow JCH, Ho JCS, Cheung KM, Johnson D, Ip BYM, Beitler JJ, Strojan P, Mäkitie AA, Eisbruch A, Ng SP, Nuyts S, Mendenhall WM, Babighian S, Ferlito A
Radiother Oncol. 2024 Mar 2;194:110200. doi: 10.1016/j.radonc.2024.110200

A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups

Jiang Y, Uhm H, Ip FC, Ouyang L, Lo RMN, Cheng EYL, Cao X, Tan CMC, Law BCH, Ortiz-Romero P, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Mok KY, Hardy J, Kwok TCY, Mok VCT, Suárez-Calvet M, Zetterberg H, Fu AKY, Ip NY
Alzheimers Dement. 2024 Mar;20(3):2000-2015. doi: 10.1002/alz.13676. Epub 2024 Jan 6. PMID: 38183344.

Tracking and navigation of a microswarm under laser speckle contrast imaging for targeted delivery

Wang Q, Wang Q, Ning Z, Chan KF, Jiang J, Wang Y, Su L, Jiang S, Wang B, Ip BYM, Ko H, Leung TWH, Chiu PWY, Yu SCH, Zhang L
Sci Robot. 2024 Feb 21;9(87):eadh1978. doi: 10.1126/scirobotics.adh1978

METTL3-mediated methylation of CYP2C19 mRNA may aggravate clopidogrel resistance in ischemic stroke patients

Tan Q, Yang L, Yuan S, Zheng D, Lin Y, Chen K, He Y, Chen S, Hao J, Dai J, He S, Mao F, Leng X, Jiang H, Yang J
Open Med (Wars). 2024 Feb 7;19(1):20240899. doi: 10.1515/med-2024-0899. PMID: 38463525; PMCID: PMC10921439.

Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification

Zhong H, Zhou X, Uhm H, Jiang Y, Cao H, Chen Y, Mak TTW, Lo RMN, Wong BWY, Cheng EYL, Mok KY, Chan ALT, Kwok TCY, Mok VCT, Ip FCF, Hardy J, Fu AKY, Ip NY
Alzheimers Dement. 2024 Feb 7. doi: 10.1002/alz.13691. Epub ahead of print. PMID: 38323937.

Prothrombin Complex Concentrate vs Conservative Management in ICH Associated With Direct Oral Anticoagulants

Ip B, Pan S, Yuan Z, Hung T, Ko H, Leng X, Liu Y, Li S, Lee SY, Cheng C, Chan H, Mok V, Soo Y, Wu X, Lui LT, Chan R, Abrigo J, Dou Q, Seiffge D, Leung T
JAMA Netw Open. 2024 Feb 5;7(2):e2354916. doi: 10.1001/jamanetworkopen.2023.54916.PMID: 38319661; PMCID: PMC10848059.

tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments

Wang B, Wang Q, Chan KF, Ning Z, Wang Q, Ji F, Yang H, Jiang S, Zhang Z, Ip BYM, Ko H, Chung JPW, Qiu M, Han J, Chiu PWY, Sung JJY, Du S, Leung TWH, Yu SCH, Zhang L
Sci Adv. 2024 Feb 2;10(5):eadk8970. doi: 10.1126/sciadv.adk8970

Use of Tirofiban in Endovascular Thrombectomy: More Questions than Answers

Ip B, Wang H, Yu SCH
Cardiovasc Intervent Radiol. 2024 Feb;47(2):216-217. doi: 10.1007/s00270-023-03644-2. Epub 2024 Jan 3. PMID: 38172252.

Study protocol of a double-blind randomized control trial of transcranial direct current stimulation in post-stroke fatigue

Tang WK, Lu H, Leung TWH, Kim JS, Fong KNK
Front Neurol. 2024 Jan 29;14:1297429. doi: 10.3389/fneur.2023.1297429

Machine Learning-Derived MRI-Based Neurodegeneration Biomarker for Alzheimer's Disease: A Multi-Database Validation Study

Fan X, Cai Y, Zhao L, Liu W, Luo Y, Au LWC, Shi L, Mok VCT
J Alzheimers Dis. 2024;97(2):883-893. doi: 10.3233/JAD-230574. PMID: 38189749.

Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA

Best JG, Ambler G, Wilson D, Du H, Lee KJ, Lim JS, Teo KC, Mak H, Kim YD, Song TJ, Selcuk Demirelli D, Nishihara M, Yoshikawa M, Kubacka M, Zietz A, Al-Shahi Salman R, Jäger HR, Lip GYH, Panos L, Goeldlin MB, Slater LA, Karayiannis CC, Phan TG, Bellut M, Abrigo J, Cheng C, Leung TW, Chu W, Chappell F, Makin SDJ, van Dam-Nolen DHK, Kooi ME, Köhler S, Staals J, Kuchcinski G, Bordet R, Dubost F, Wardlaw JM, Soo YOY, Fluri F, Srikanth VK, Jung S, Peters N, Hara H, Yakushiji Y, Necioglu Orken D, Heo JH, Lau GKK, Bae HJ, Werring DJ
Neurology. 2024 Jan 9;102(1):e207795. doi: 10.1212/WNL.0000000000207795

Shift in Tissue-Specific Immune Niches and CD137 Expression in Tuberculoma of Pembrolizumab-Treated Nasopharyngeal Carcinoma Patients

Kam NW, Lo AWI, Hung DTY, Ko H, Wu KC, Kwong DLW, Lam KO, Leung TW, Che CM, Lee VHF
Cancers (Basel). 2024 Jan 8;16(2):268. doi: 10.3390/cancers16020268. PMID: 38254759; PMCID: PMC10813936.

Cerebral microinfarcts revisited: Detection, causes, and clinical relevance

Huang J, Biessels GJ, de Leeuw FE, Ii Y, Skoog I, Mok V, Chen C, Hilal S
Int J Stroke. 2024 Jan;19(1):7-15. doi: 10.1177/17474930231187979

Diagnostic Accuracy and Field for Improvement of Frameless Stereotactic Brain Biopsy: A Focus on Nondiagnostic Cases

He Z, Zhu CXL, Chan DTM, Cheung TCY, Ng HK, Mok VCT, Poon WS
J Neurol Surg A Cent Eur Neurosurg. 2024 Jan;85(1):48-61. doi: 10.1055/a-1994-8033. Epub 2022 Dec 8. PMID: 36481998.

2023

Cerebral haemodynamics in symptomatic intracranial atherosclerotic disease: a narrative review of the assessment methods and clinical implications

Liu Y, Li S, Tian X, Leung TW, Liu L, Liebeskind DS, Leng X
Stroke Vasc Neurol. 2023 Dec 29;8(6):521-530. doi: 10.1136/svn-2023-002333

Prevalence of post-stroke cognitive impairment and associated risk factors in Chinese stroke survivors

Chau JPC, Lo SHS, Zhao J, Choi KC, Butt L, Lau AYL, Mok VCT, Kwok ZCM, Thompson DR
J Neurol Sci. 2023 Dec 15;455:122805. doi: 10.1016/j.jns.2023.122805

Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission

Feigin VL, Owolabi MO; World Stroke Organization–Lancet Neurology Commission Stroke Collaboration Group
Lancet Neurol. 2023 Dec;22(12):1160-1206. doi: 10.1016/S1474-4422(23)00277-6

Altered Impulsivity Across Drug-Naïve Parkinsonism, Isolated Rapid Eye Movement Sleep Behavior Disorder, and Their High-Risk Relatives

Zhou L, Li SX, Chau SW, Huang B, Wang J, Tang S, Chan JW, Zhang J, Yu MW, Tsang JC, Hu MT, Mok VC, Wing YK, Liu Y
Ann Neurol. 2023 Nov 23. doi: 10.1002/ana.26836

Editorial: Intracranial atherosclerotic disease: epidemiology, imaging, treatment and prognosis, volume II.

Leng X, Prabhakaran S, Lee JS, Abou-Chebl A, Liebeskind DS
Front Neurol. 2023 Nov 21;14:1310281. doi: 10.3389/fneur.2023.1310281

The TriAGe + score for vertigo or dizziness: A validation study in a university hospital emergency department in Hong Kong

Yu AH, Leung LY, Leung TWH, Abrigo JM, Cheung KH, Cheng CH, Graham CA
Am J Emerg Med. 2023 Nov 10;77:39-45. doi: 10.1016/j.ajem.2023.10.055

White Matter Hyperintensity Volume and Poststroke Cognition: An Individual Patient Data Pooled Analysis of 9 Ischemic Stroke Cohort Studies

de Kort FAS, Coenen M, Weaver NA, Kuijf HJ, Aben HP, Bae HJ, Bordet R, Cammà G, Chen CPLH, Dewenter A, Duering M, Fang R, van der Giessen RS, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kan CN, Kim J, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Lim JS, Lopes R, Mok VCT, Staals J, Venketasubramanian N, Verhagen CM, Verhey FRJ, Wardlaw JM, Xu X, Yu KH, Biesbroek JM, Biessels GJ
Stroke. 2023 Dec;54(12):3021-3029. doi: 10.1161/STROKEAHA.123.044297

Cerebral hemodynamics and stroke risks in symptomatic intracranial atherosclerotic stenosis with internal versus cortical borderzone infarcts: A computational fluid dynamics study

Li S, Tian X, Ip B, Feng X, Ip HL, Abrigo J, Lan L, Liu H, Zheng L, Liu Y, Liu Y, Ma KK, Fan FS, Ma SH, Fang H, Xu Y, Lau AY, Leung H, Soo YO, Mok VC, Wong KS, Leng X, Leung TW
J Cereb Blood Flow Metab. 2023 Oct 28:271678X231211449. doi: 10.1177/0271678X231211449

The role of visual rating and automated brain volumetry in early detection and differential diagnosis of Alzheimer's disease

Mai Y, Cao Z, Zhao L, Yu Q, Xu J, Liu W, Liu B, Tang J, Luo Y, Liao W, Fang W, Ruan Y, Lei M, Mok VCT, Shi L, Liu J; Alzheimer's Disease Neuroimaging Initiative
CNS Neurosci Ther. 2023 Oct 21. doi: 10.1111/cns.14492

Hemodynamic significance of intracranial atherosclerotic disease and ipsilateral imaging markers of cerebral small vessel disease

Zheng L, Tian X, Abrigo J, Fang H, Ip BY, Liu Y, Li S, Liu Y, Lan L, Liu H, Ip HL, Fan FS, Ma SH, Ma K, Lau AY, Soo YO, Leung H, Mok VC, Wong LK, Xu Y, Liu L, Leng X, Leung TW
Eur Stroke J. 2023 Oct 6:23969873231205669. doi: 10.1177/23969873231205669

Telemedicine acceptance by older adults in Hong Kong during a hypothetical severe outbreak and after the COVID-19 pandemic: a cross-sectional cohort survey

Choi MCY, Chu SH, Siu LL, Tse AG, Wu JCY, Fung H, Chiu BCF, Mok VCT
Hong Kong Med J. 2023 Oct;29(5):412-420. doi: 10.12809/hkmj219747. Epub 2023 Oct 5. PMID: 37794613.

Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Exalto LG, Weaver NA, Kuijf HJ, Aben HP, Bae HJ, Best JG, Bordet R, Chen CPLH, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kim J, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Lim JS, Makin SDJ, Mok VCT, van Oostenbrugge RJ, Roussel M, Staals J, Valdés-Hernández MDC, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xu X, van Zandvoort MJE, Biesbroek JM, Chappell FM, Biessels GJ
Stroke. 2023 Sep;54(9):2296-2303. doi: 10.1161/STROKEAHA.123.042507

Virtual Multidisciplinary Stroke Care Clinic for Community-Dwelling Stroke Survivors: A Randomized Controlled Trial

Lo SHS, Chau JPC, Lau AYL, Choi KC, Shum EWC, Lee VWY, Hung SS, Mok VCT, Siow EKC, Ching JYL, Mirchandani K, Lam SKY
Stroke. 2023 Oct;54(10):2482-2490. doi: 10.1161/STROKEAHA.123.043605

Endovascular Treatment for Acute Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Disease

Huo X, Sun D, Chen W, Han H, Abdalkader M, Puetz V, Yi T, Wang H, Liu R, Tong X, Jia B, Ma N, Gao F, Mo D, Yan B, Mitchell PJ, Leung TW, Yavagal DR, Albers GW, Costalat V, Fiehler J, Zaidat OO, Jovin TG, Liebeskind DS, Nguyen TN, Miao Z
Semin Neurol. 2023 Jun;43(3):337-344. doi: 10.1055/s-0043-1771207

Novel retinal imaging biomarkers for cognitive decline: abridged secondary publication

Cheung CY, Chan VTT, Au LWC, Tham CC, Kowk TCY, Mok CTV
Hong Kong Med J. 2023 Aug;29 Suppl 4(4):4-7. PMID: 37690798.

Recent Evidence of Large-Core Thrombectomy in Acute Ischemic Stroke-Certainties and Uncertainties

Ip BYM, Ma SH, Yu SCH
Cardiovasc Intervent Radiol. 2023 Jul 18. doi: 10.1007/s00270-023-03499-7.

Menstrually-related migraine shapes the structural similarity network integration of brain

Li X, Hao H, Li Y, Au LW, Du G, Gao X, Yan J, Tong RK, Lou W
Cereb Cortex. 2023 Jul 6:bhad250. doi: 10.1093/cercor/bhad250.

Familial α-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder

Wang J, Lam SP, Huang B, Liu Y, Zhang J, Yu MWM, Tsang JCC, Zhou L, Chau SWH, Chan NY, Chan JWY, Schenck CH, Li SX, Mok VCT, Ma KKY, Chan AYY, Wing YK.
J Neurol Neurosurg Psychiatry. 2023 Nov;94(11):893-903. doi: 10.1136/jnnp-2022-330922.

High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration

Kwok AJ, Lu J, Huang J, Ip BY, Mok VCT, Lai HM, Ko H
Seminars in cell & developmental biology. 2023 Jun 26:S1084-9521(23)00131-3. doi: 10.1016/j.semcdb.2023.06.005.

Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy

Tan Z, Zhang L, Huang L, Qiao H, Guan M, Yang B, Yang P, Zhang Y, Shen H, Zhou Y, Hong B, Shi H, Han H, Leng X, Dong Y, Lian C, Chen W, Xu A, Liu J
Stroke Vasc Neurol. 2023 Jun 8:svn-2022-002257. doi: 10.1136/svn-2022-002257

What is a Challenging Clot? : A DELPHI Consensus Statement from the CLOTS 7.0 Summit

Ospel JM, Mirza M, Clarençon F, Siddiqui A, Doyle K, Consoli A, Mokin M, Ullberg T, Zaidat O, Bourcier R, Kulcsar Z, Gounis MJ, Liebeskind DS, Fiehler J, Narata AP, Ribo M, Jovin T, Sakai N, Rai A, McCarthy R, Dorn F, Andersson T, Majoie CBLM, Hanel R, Jadhav A, Riedel C, Chamorro A, Brinjikji W, Costalat V, DeMeyer SF, Nogueira RG, Cognard C, Montaner J, Leung TW, Molina C, van Beusekom H, Davalos A, Weisel J, Chapot R, Möhlenbruch M, Brouwer P
Clinical Neuroradiology. 2023 Jun 7. doi: 10.1007/s00062-023-01301-2.

Editorial: minor stroke is not minor

Leng X, Wang D
Stroke Vasc Neurol. 2023 Jun;8(3):175-177. doi: 10.1136/svn-2022-002049

Association of Alternative Anticoagulation Strategies and Outcomes in Patients With Ischemic Stroke While Taking a Direct Oral Anticoagulant. Neurology

Bonaventure Ip YM, Lau KK, Ko H, Lau L, Yao A, Lai-Hung Wong G, Cheuk-Fung Yip T, Leng X, Chan H, Chan H, Mok V, Soo YOY, Seiffge D, Leung TW
Neurology. 2023 May 24:10.1212/WNL.0000000000207422. doi: 10.1212/WNL.0000000000207422.

Effects of Acupuncture upon cerebral hemodynamics in cerebral small vessel disease: A pilot study

Mok VCT, Tang EC, Lau AY, Au D, Ju Y,Lan BYK, Wong A, Au L
Cerebral Circulation - Cognition and Behavior. 2023 May;4:100168. doi: doi.org/10.1016/j.cccb.2023.100168

Neuroimaging standards for research into small vessel disease-advances since 2013.

Duering M, Biessels GJ, Brodtmann A, Chen C, Cordonnier C, de Leeuw FE, Debette S, Frayne R, Jouvent E, Rost NS, Ter Telgte A, Al-Shahi Salman R, Backes WH, Bae HJ, Brown R, Chabriat H, De Luca A, deCarli C, Dewenter A, Doubal FN, Ewers M, Field TS, Ganesh A, Greenberg S, Helmer KG, Hilal S, Jochems ACC, Jokinen H, Kuijf H, Lam BYK, Lebenberg J, MacIntosh BJ, Maillard P, Mok VCT, Pantoni L, Rudilosso S, Satizabal CL, Schirmer MD, Schmidt R, Smith C, Staals J, Thrippleton MJ, van Veluw SJ, Vemuri P, Wang Y, Werring D, Zedde M, Akinyemi RO, Del Brutto OH, Markus HS, Zhu YC, Smith EE, Dichgans M, Wardlaw JM.
Lancet Neurology. 2023 May 23:S1474-4422(23)00131-X. doi: 10.1016/S1474-4422(23)00131-X.

Gut microbiome dysbiosis across early Parkinson's disease, REM sleep behavior disorder and their first-degree relatives

Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, Zhang J, Chan PKS, Yeoh YK, Chen Z, Zhou L, Wong SH, Mok VCT, To KF, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK
Nature Communications. 2023 May 2;14(1):2501. doi: 10.1038/s41467-023-38248-4

Early- and late-onset of isolated rapid eye movement sleep behavior disorder: A retrospective cohort study

Zhou L, Huang B, Wang J, Chau SW, Chan JW, Zhang J, Yu MW, Tsang JC, Li SX, Mok VC, Wing YK, Liu Y
Sleep Medicine. 2023 May;105:1-8. doi: 10.1016/j.sleep.2023.03.007.

Comparing machine learning-derived MRI-based and blood-based neurodegeneration biomarkers in predicting syndromal conversion in early AD

Cai Y, Fan X, Zhao L, Liu W, Luo Y, Lau AYL, Au LWC, Shi L, Lam BYK, Ko H, Mok VCT
Alzheimer's & dementia. 2023 Apr 23. doi: 10.1002/alz.13083.

Principles of deep immunohistochemistry for 3D histology

Yau CN, Lai HM, Lee K, Kwok AJ, Huang J, Ko H
Cell Reports Methods. 2023 Apr 20;doi:j.crmeth.2023.100458.

Short-term Trajectories of Poststroke Cognitive Function: A STROKOG Collaboration Study

Lo JW, Crawford JD, Desmond DW, Bae HJ, Lim JS, Godefroy O, Roussel M, Köhler S, Staals J, Verhey F, Chen C, Xu X, Chong E, Kandiah N, Bordet R, Dondaine T, Mendyk AM, Brodaty H, Traykov L, Mehrabian S, Petrova N, Lipnicki DM, Pan Lam BC, Sachdev PS; Stroke and Cognition (STROKOG) Collaboration
Neurology. 2023 Apr 18:10.1212/WNL.0000000000207281. doi: 10.1212/WNL.0000000000207281.

Mechanical Thrombectomy Global Access For Stroke (MT-GLASS): A Mission Thrombectomy (MT-2020 Plus) Study

Asif KS, Otite FO, Desai SM, Herial N, Inoa V, Al-Mufti F, Jadhav AP, Dmytriw AA, Castonguay A, Khandelwal P, Potter-Vig J, Szeder V, Kulman T, Urrutia V, Masoud H, Toth G, Limaye K, Aroor S, Brinjikji W, Rai A, Pandian J, Gebreyohanns M, Leung T, Mansour O, Demchuk AM, Huded V, Martins S, Zaidat O, Huo X, Campbell B, Sylaja PN, Miao Z, Saver J, Ortega-Gutierrez S, Yavagal DR; Global Executive Committee of the MT-GLASS Study
Circulation. 2023 Apr 18;147(16):1208-1220. doi: 10.1161/CIRCULATIONAHA.122.063366

Deep learning-based polygenic risk analysis for Alzheimer's disease prediction

Zhou X, Chen Y, Ip FCF, Jiang Y, Cao H, Lv G, Zhong H, Chen J, Ye T, Chen Y, Zhang Y, Ma S, Lo RMN, Tong EPS; Alzheimer’s Disease Neuroimaging Initiative; Mok VCT, Kwok TCY, Guo Q, Mok KY, Shoai M, Hardy J, Chen L, Fu AKY, Ip NY
Communications medicine. 2023 Apr 6;3(1):49. doi: 10.1038/s43856-023-00269-x. PMID: 37024668; PMCID: PMC10079691.

Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation

Soo Y, Zietz A, Yiu B, Mok VCT, Polymeris AA, Seiffge D, Ambler G, Wilson D, Leung TWH, Tsang SF, Chu W, Abrigo J, Cheng C, Lee KJ, Lim JS, Shiozawa M, Koga M, Chabriat H, Hennerici M, Wong YK, Mak H, Collet R, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BY, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Demirelli DS, Bornstein NM, Assayag EB, Hallevi H, Molad J, Nishihara M, Tanaka J, Coutts SB, Kappelle LJ, Al-Shahi Salman R, Jager R, Lip GYH, Goeldlin MB, Panos LD, Mas JL, Legrand L, Karayiannis C, Phan T, Bellut M, Chappell F, Makin S, Hayden D, Williams D, van Dam-Nolen DHK, Nederkoorn PJ, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Mendyk AM, Köhler S, van Oostenburgge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, Hendrikse J, Wardlaw J, Kelly P, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Smith EE, Hara H, Yakushiji Y, Necioglu Orken D, Fazekas F, Thijs V, Heo JH, Veltkamp R, Ay H, Imaizumi T, Lau KK, Jouvent E, Toyoda K, Yoshimura S, Bae HJ, Martí-Fàbregas J, Prats-Sánchez L, Lyrer P, Best J, Werring D, Engelter ST, Peters N; Microbleeds International Collaborative Network
Annals of neurology. 2023 Mar 17. doi: 10.1002/ana.26642.

Cerebral Hemodynamics Underlying Artery-to-Artery Embolism in Symptomatic Intracranial Atherosclerotic Disease

Feng X, Fang H, Ip BYM, Chan KL, Li S, Tian X, Zheng L, Liu Y, Lan L, Liu H, Abrigo J, Ma SH, Fan FSY, Ip VHL, Soo YOY, Mok VCT, Song B, Leung TW, Xu Y, Leng X
Translational stroke research. 2023 Mar 10. doi: 10.1007/s12975-023-01146-4.

Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

Shi Z, Yu P, Lin WJ, Chen S, Hu X, Chen S, Cheng J, Liu Q, Yang Y, Li S, Zhang Z, Xie J, Jiang J, He B, Li Y, Li H, Xu Y, Zeng J, Huang J, Mei J, Cai J, Chen J, Wu LJ, Ko H, Tang Y
Neuron. 2023 Mar 1;111(5):696-710.e9. doi: 10.1016/j.neuron.2022.12.009.

Clinically Ineffective Reperfusion After Endovascular Therapy in Acute Ischemic Stroke

Nie X, Leng X, Miao Z, Fisher M, Liu L
Stroke. 2023 Mar;54(3):873-881. doi: 10.1161/STROKEAHA.122.038466

Stroke in China

Markus HS, Leung T
Int J Stroke. 2023 Mar;18(3):256-258. doi: 10.1177/17474930231157479. PMID: 36803086.

Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination With BNT162b2 Increased Risk of Bell's Palsy: A Nested Case-Control and Self-Controlled Case Series Study

Wan EYF, Chui CSL, Ng VWS, Wang Y, Yan VKC, Lam ICH, Fan M, Lai FTT, Chan EWY, Li X, Wong CKH, Chung RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Lau CS, Leung GM, Wong ICK
Clin Infect Dis. 2023 Feb 8;76(3):e291-e298. doi: 10.1093/cid/ciac460

Association of calcium channel blockers with lower incidence of intracranial aneurysm rupture and growth in hypertensive patients

Liu Q, Li J, Zhang Y, Leng X, Mossa-Basha M, Levitt MR, Wang S, Zhu C
J Neurosurg. 2023 Jan 27;139(3):651-660. doi: 10.3171/2022.12.JNS222428

Good collaterals and better outcomes after EVT for basilar artery occlusion: a systematic review and meta-analysis

Liu Y, Tian X, Leung TW, Liu L, Liebeskind DS, Leng X
International journal of stroke. 2023 Jan 19:17474930231154797. doi: 10.1177/17474930231154797.

An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish

Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H
Nature communications. 2023 Jan 14;14(1):227. doi: 10.1038/s41467-023-35836-2. PMID: 36641479; PMCID: PMC9840631.

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants

Meinel TR, Wilson D, Gensicke H, Scheitz JF, Ringleb P, Goganau I, Kaesmacher J, Bae HJ, Kim DY, Kermer P, Suzuki K, Kimura K, Macha K, Koga M, Wada S, Altersberger V, Salerno A, Palanikumar L, Zini A, Forlivesi S, Kellert L, Wischmann J, Kristoffersen ES, Beharry J, Barber PA, Hong JB, Cereda C, Schlemm E, Yakushiji Y, Poli S, Leker R, Romoli M, Zedde M, Curtze S, Ikenberg B, Uphaus T, Giannandrea D, Portela PC, Veltkamp R, Ranta A, Arnold M, Fischer U, Cha JK, Wu TY, Purrucker JC, Seiffge DJ; DOAC-IVT Writing Group for the International DOAC-IVT, TRISP, and CRCS-K-NIH Collaboration
JAMA neurology. 2023 Jan 3;80(3):233–43. doi: 10.1001/jamaneurol.2022.4782.

The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis

Lam BYK, Cai Y, Akinyemi R, Biessels GJ, van den Brink H, Chen C, Cheung CW, Chow KN, Chung HKH, Duering M, Fu ST, Gustafson D, Hilal S, Hui VMH, Kalaria R, Kim S, Lam MLM, de Leeuw FE, Li ASM, Markus HS, Marseglia A, Zheng H, O'Brien J, Pantoni L, Sachdev PS, Smith EE, Wardlaw J, Mok VCT
International journal of stroke. 2023 Jan;18(1):15-27. doi: 10.1177/17474930221137019.

2022

Efficacy and safety of cilostazol in decreasing progression of cerebral white matter hyperintensities-A randomized controlled trial

Ip BYM, Lam BYK, Hui VMH, Au LWC, Liu MWT, Shi L, Lee VWY, Chu WCW, Leung TW, Ko H, Mok VCT
Alzheimer’s & Dementia – Translational Research & Clinical Interventions. 2022 Dec 27;8(1):e12369. doi: 10.1002/trc2.12369. PMID: 36583111; PMCID: PMC9793825.

Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study

Chau SWH, Liu Y, Zhang J, Leung E, Chen S, Ho CL, Chan JWY, Tsang CC, Li SX, Huang B, Lam SP, Mok VC, Wing YK
Parkinsonism & Related Disorders. 2022 Dec 26;107:105271. doi: 10.1016/j.parkreldis.2022.105271.

Stroke Risk and Antithrombotic Treatment During Follow-up of Patients With Ischemic Stroke and Cortical Superficial Siderosis

Martí-Fàbregas J, Camps-Renom P, Best JG, Ramos-Pachon A, Guasch-Jiménez M, Martinez-Domeño A, Guisado-Alonso D, Gómez-Ansón BM, Ambler G, Wilson D, Lee KJ, Lim JS, Bae HJ, Shiozawa M, Koga M, Toyoda K, Hennerici MG, Chabriat H, Jouvent E, Kwun Wong DY, Mak H, Lau KK, Kim YD, Song TJ, Heo JH, Eppinger S, Gattringer T, Uysal E, Demirelli DS, Bornstein N, Ben Assayag E, Hallevi H, Molad JA, Nishihara M, Tanaka J, Hara H, Yakushiji Y, Coutts SB, Smith E, Polymeris AA, Wagner B, Seiffge D, Lyrer PA, Peters N, Engelter ST, Al-Shahi Salman R, Jäger HR, Lip GYH, Goeldlin M, Panos L, Karayiannis CC, Phan TG, Srikanth VK, Christ N, Gunkel S, Fluri F, Leung TW, Soo YOY, Chu W, Abrigo J, Barbato C, Browning S, Simister R, Mendyk AM, Bordet R, Hilal S, Gyanwali B, Chen C, Jung S, Orken DN, Werring D, Prats-Sanchez L; and Microbleeds International Collaborative Network (MICON)
Neurology. 2022 Dec 19:10.1212/WNL.0000000000201723. doi: 10.1212/WNL.0000000000201723.

Associations of hematological and biochemical markers with intracranial atherosclerotic stenosis in stroke-free populations: A systematic review and meta-analysis of observational studies

Tian X, Zheng L, Leung TW, Leng X
Nutrition, metabolism, and cardiovascular diseases . 2023 Feb;33(2):287-298. doi: 10.1016/j.numecd.2022.12.007.

Effects of stent shape on focal hemodynamics in intracranial atherosclerotic stenosis: A simulation study with computational fluid dynamics modeling

Liu H, Liu Y, Ip BYM, Ma SH, Abrigo J, Soo YOY, Leung TW, Leng X
Frontiers in neurology. 2022 Dec 13;13:1067566. doi: 10.3389/fneur.2022.1067566.

Pre-operative cognitive burden as predictor of motor outcome following bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease

Tang V, Zhu XL, Lau C, Chan A, Ma K, Yeung J, Cheung T, Abrigo J, Chan DYC, Chan D, Mok V, Poon WS
Neurological sciences. 2022 Dec;43(12):6803-6811. doi: 10.1007/s10072-022-06370-8.

Thromboembolic Risks with Concurrent Direct Oral Anticoagulants and Antiseizure Medications: A Population-Based Analysis

Ip BY, Ko H, Wong GL, Yip TC, Lau LH, Lau AY, Leng X, Leung H, Chan HH, Chan HY, Mok VC, Soo YO, Leung TW
CNS Drugs. 2022 Dec;36(12):1313-1324. doi: 10.1007/s40263-022-00971-9.

Current and Future Trends in Biomarkers for the Early Detection of Alzheimer's Disease in Asia: Expert Opinion

Kandiah N, Choi SH, Hu CJ, Ishii K, Kasuga K, Mok VCT
Journal of Alzheimer's disease reports. 2022 Nov 22;6(1):699-710. doi: 10.3233/ADR-220059.

Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder

Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y
Journal of sleep research. 2022 Nov 21:e13791. doi: 10.1111/jsr.13791.

Faecal microbiome-based machine learning for multi-class disease diagnosis

Su Q, Liu Q, Lau RI, Zhang J, Xu Z, Yeoh YK, Leung TWH, Tang W, Zhang L, Liang JQY, Yau YK, Zheng J, Liu C, Zhang M, Cheung CP, Ching JYL, Tun HM, Yu J, Chan FKL, Ng SC
Nature communications. 2022 Nov 10;13(1):6818. doi: 10.1038/s41467-022-34405-3. PMID: 36357393.

A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study

Cheung CY, Ran AR, Wang S, Chan VTT, Sham K, Hilal S, Venketasubramanian N, Cheng CY, Sabanayagam C, Tham YC, Schmetterer L, McKay GJ, Williams MA, Wong A, Au LWC, Lu Z, Yam JC, Tham CC, Chen JJ, Dumitrascu OM, Heng PA, Kwok TCY, Mok VCT, Milea D, Chen CL, Wong TY
Lancet Digital health. 2022 Nov;4(11):e806-e815. doi: 10.1016/S2589-7500(22)00169-8.

Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review

Markus HS, van Der Flier WM, Smith EE, Bath P, Biessels GJ, Briceno E, Brodtman A, Chabriat H, Chen C, de Leeuw FE, Egle M, Ganesh A, Georgakis MK, Gottesman RF, Kwon S, Launer L, Mok V, O'Brien J, Ottenhoff L, Pendlebury S, Richard E, Sachdev P, Schmidt R, Springer M, Tiedt S, Wardlaw JM, Verdelho A, Webb A, Werring D, Duering M, Levine D, Dichgans M
JAMA Neurology. 2022 Nov 1;79(11):1187-1198. doi: 10.1001/jamaneurol.2022.2262.

The Hong Kong Grocery Shopping Dialog Task (HK-GSDT): A Quick Screening Test for Neurocognitive Disorders

Gong X, Wong PCM, Fung HH, Mok VCT, Kwok TCY, Woo J, Wong KH, Meng H
International journal of environmental research and public health. 2022 Oct 15;19(20):13302. doi: 10.3390/ijerph192013302.

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

Tang PC, Chung JY, Liao J, Chan MK, Chan AS, Cheng G, Li C, Huang XR, Ng CS, Lam EW, Zhang D, Ho YP, To KF, Leung KT, Jiang X, Ko H, Lee TL, Lan HY, Tang PM
Science advances. 2022 Oct 7;8(40):eabn5535. doi: 10.1126/sciadv.abn5535.

Improved sensitivity and precision in multicentre diffusion MRI network analysis using thresholding and harmonization

de Brito Robalo BM, de Luca A, Chen C, Dewenter A, Duering M, Hilal S, Koek HL, Kopczak A, Lam BYK, Leemans A, Mok V, Onkenhout LP, van den Brink H, Biessels GJ
NeuroImage Clinical. 2022;36:103217. doi: 10.1016/j.nicl.2022.103217.

Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics

Tian X, Fang H, Lan L, Ip HL, Abrigo J, Liu H, Zheng L, Fan FSY, Ma SH, Ip B, Song B, Xu Y, Li J, Zhang B, Xu Y, Soo YOY, Mok V, Wong KS, Leung TW, Leng X
Stroke and vascular neurology. 2022 Sep 14:svn-2022-001606. doi: 10.1136/svn-2022-001606. PMID: 36104090.

Validation of the Alzheimer's disease-resemblance atrophy index in classifying and predicting progression in Alzheimer's disease

He Q, Shi L, Luo Y, Wan C, Malone IB, Mok VCT, Cole JH, Anatürk M
Frontiers in aging neuroscience. 2022 Aug 5;14:932125. doi: 10.3389/fnagi.2022.932125.

Deep-tissue two-photon microscopy with a frequency-doubled all-fiber mode-locked laser at 937 nm

H He, H Tang, M Zhou, HM Lai, T Qiao, Y Ren, CSW Lai, H Ko, X Wei, Yang Z, Tsia KK, Wong KKY
Advanced Photonics Nexus. 2022 Jul 25; 1(2): 026001. https://doi.org/10.1117/1.APN.1.2.026001.

A cross-sectional study of COVID-19 vaccination patterns among patients with epilepsy in Hong Kong

Chan CC, Choi CH, Lui WT, Ip B, Ma KK, Ma SH, Fan FS, Au L, Lau A, Chan AY, Ip V, Soo Y, Leung T, Mok V, Leung H
Epilepsia Open. 2022 Jul 22:10.1002/epi4.12629. doi: 10.1002/epi4.12629. Epub ahead of print. PMID: 35867810; PMCID: PMC9349844.

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease

Jiang Y, Zhou X, Wong HY, Ouyang L, Ip FCF, Chau VMN, Lau SF, Wu W, Wong DYK, Seo H, Fu WY, Lai NCH, Chen Y, Chen Y, Tong EPS; Alzheimer’s Disease Neuroimaging Initiative; Mok VCT, Kwok TCY, Mok KY, Shoai M, Lehallier B, Losada PM, O'Brien E, Porter T, Laws SM, Hardy J, Wyss-Coray T, Masters CL, Fu AKY, Ip NY
Nature aging. 2022 Jul;2(7):616-634. doi: 10.1038/s43587-022-00241-9.

Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder.

Zhou L, Chau SWH, Liu Y, Wang J, Zhang J, Chan NY, Chan JWY, Huang B, Chen S, Li SX, Mok VCT, Wing YK
NPJ Parkinson's disease. 2022 Jul 14;8(1):91. doi: 10.1038/s41531-022-00356-1. PMID: 35835768.

Automated brain volumetric measures with AccuBrain: version comparison in accuracy, reproducibility and application for diagnosis

Zhao L, Luo Y, Mok V, Shi L
BMC medical imaging. 2022 Jul 4;22(1):117. doi: 10.1186/s12880-022-00841-2.

Antibody stabilization for thermally accelerated deep immunostaining

Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H
Nature Methods. 19, 1137–1146 (2022). https://doi.org/10.1038/s41592-022-01569-1

Thromboembolic events and hemorrhagic stroke after mRNA (BNT162b2) and inactivated (CoronaVac) covid-19 vaccination: A self-controlled case series study

Chui CSL, Fan M, Wan EYF, Leung MTY, Cheung E, Yan VKC, Gao L, Ghebremichael-Weldeselassie Y, Man KKC, Lau KK, Lam ICH, Lai FTT, Li X, Wong CKH, Chan EW, Cheung CL, Sing CW, Lee CK, Hung IFN, Lau CS, Chan JYS, Lee MK, Mok VCT, Siu CW, Chan LST, Cheung T, Chan FLF, Leung AY, Cowling BJ, Leung GM, Wong ICK
EClinicalMedicine. 2022 Jun 25;50:101504. doi: 10.1016/j.eclinm.2022.101504. PMID: 35770253; PMCID: PMC9233170.

The Correlation Between White Matter Hyperintensity Burden and Regional Brain Volumetry in Patients With Alzheimer's Disease

Cao Z, Mai Y, Fang W, Lei M, Luo Y, Zhao L, Liao W, Yu Q, Xu J, Ruan Y, Xiao S, Mok VCT, Shi L, Liu J; Alzheimer's Disease Neuroimaging Initiative
Frontiers in human neuroscience. 2022 Jun 14;16:760360. doi: 10.3389/fnhum.2022.760360.

High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease

Huang S, Zhou X, Liu Y, Luo J, Lv Z, Shang P, Zhang W, Lin B, Huang Q, Feng Y, Wang W, Tao S, Wang Y, Zhang C, Chen L, Shi L, Luo Y, Mok VCT, Pan S, Xie H
Frontiers in neuroscience. 2022 Jun 8;16:896437. doi: 10.3389/fnins.2022.896437.

mRNA (BNT162b2) COVID-19 vaccination increased risk of Bell's palsy: a nested case control and self-controlled case series study

Wan EYF, Chui CSL, Ng VWS, Wang Y, Yan VKC, Lam ICH, Fan M, Lai FTT, Chan EWY, Li X, Wong CKH, Chung RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Lau CS, Leung GM, Wong ICK
Clin Infect Dis. 2022 Jun 8:ciac460. doi: 10.1093/cid/ciac460. Epub ahead of print. PMID: 35675702.

Collateral Flow in Intracranial Atherosclerotic Disease

Leng X, Leung TW
Transl Stroke Res. 2022 Jun 8. doi: 10.1007/s12975-022-01042-3. Epub ahead of print. PMID: 35672561.

890-nm-excited SHG and fluorescence imaging enabled by an all-fiber mode-locked laser

He H, Zhou M, Qiao T, Lai HM, Ran Q, Ren YX, Ko H, Zheng C, Tsia KK, Wong KKY
Optics letters. 2022 Jun 1;47(11):2710-2713. doi: 10.1364/OL.455081. PMID: 35648911.

Probiotic supplementation demonstrates therapeutic potential in treating gut dysbiosis and improving neurocognitive function in age-related dementia

Meng HYH, Mak CCH, Mak WY, Zuo T, Ko H, Chan FKL
European journal of nutrition. 2022 Jun;61(4):1701-1734. doi: 10.1007/s00394-021-02760-4.

Risk factors for delayed-onset dementia after stroke or transient ischemic attack-A five-year longitudinal cohort study

Ismail M, Mok VC, Wong A, Au L, Yiu B, Wang Z, Chu WC, Chan AY, Fan FS, Ma SH, Ip V, Ip B, Ma K, Leung H, Soo YO, Leung TW, Ko H, Lau AY, Lam BY
International journal of stroke. 2022 Jun;17(5):517-525. doi: 10.1177/17474930211026519.

Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

Shi M, Leng X, Li Y, Chen Z, Cao Y, Chung T, Ip BY, Ip VH, Soo YO, Fan FS, Ma SH, Ma K, Chan AYY, Au LW, Leung H, Lau AY, Mok VC, Choy KW, Dong Z, Leung TW
Stroke Vasc Neurol. 2022 Jun;7(3):182-189. doi: 10.1136/svn-2021-001157.

Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease

Chen Q, Abrigo J, Liu W, Han EY, Yeung DKW, Shi L, Au LWC, Deng M, Chen S, Leung EYL, Ho CL, Mok VCT, Chu WCW
Brain Sciences. 2022; 12(6):722. https://doi.org/10.3390/brainsci12060722.

Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study

Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK.
Neurology. 2022 May 12:10.1212/WNL.0000000000200707. doi: 10.1212/WNL.0000000000200707. Epub ahead of print. PMID: 35550550.

Cerebral Augmentation Effect Induced by External Counterpulsation Is Not Related to Impaired Dynamic Cerebral Autoregulation in Ischemic Stroke

Xiong L, Chen X, Liu J, Wong LKS, Leung TW
Front Neurol. 2022 May 3;13:784836. doi: 10.3389/fneur.2022.784836. PMID: 35592467; PMCID: PMC9110640.

Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

Zhao L, Zhang CL, He L, Chen Q, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L, Huang Y
Diabetes. 2022 May 1;71(5):1099-1114. doi: 10.2337/db21-0660. PMID: 35179568.

Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma

Kam NW, Wu KC, Dai W, Wang Y, Yan LYC, Shakya R, Khanna R, Qin Y, Law S, Lo AWI, Lee VHF, Guan XY, Kwong DL
Angiogenesis. 2022 May;25(2):181-203. doi: 10.1007/s10456-021-09819-0. Epub 2021 Oct 6. PMID: 34617194; PMCID: PMC8494172.

AD Resemblance Atrophy Index of Brain Magnetic Resonance Imaging in Predicting the Progression of Mild Cognitive Impairment Carrying Apolipoprotein E-ε4 Allele. Frontiers in aging neuroscience

Mai Y, Cao Z, Xu J, Yu Q, Yang S, Tang J, Zhao L, Fang W, Luo Y, Lei M, Mok VCT, Shi L, Liao W, Liu J; Alzheimer’s Disease Neuroimaging Initiative
Frontiers in aging neuroscience. 2022 Apr 28;14:859492. doi: 10.3389/fnagi.2022.859492.

Small vessel disease burden may not portend unfavorable outcome after thrombectomy for acute large vessel occlusion

Zheng L, Leng X, Nie X, Yan H, Tian X, Pan Y, Yang Z, Wen M, Pu Y, Gu W, Miao Z, Leung TW, Liu L
Eur Radiol. 2022 Apr 27. doi: 10.1007/s00330-022-08795-3. Epub ahead of print. PMID: 35475935.

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Biesbroek JM, Weaver NA, Aben HP, Kuijf HJ, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Valdés-Hernández MDC, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biessels GJ
Neuroimage Clin. 2022 Apr 27;34:103018. doi: 10.1016/j.nicl.2022.103018. Epub ahead of print. PMID: 35504223; PMCID: PMC9079101.

Direct room temperature synthesis of α-CsPbI3 perovskite nanocrystals with high photoluminescence quantum yields: implications for lighting and photovoltaic applications

Lai HM, Lu Z, Choi CK, Zhou W, Yau JCN, Tang BZ, Ko H
ACS Applied Nano Materials. 2022 Apr 27;doi:10.1021/acsanm.2c00732.

Effects of Mindfulness Yoga Versus Conventional Physical Exercises on Symptom Experiences and Health-related Quality of Life in People with Parkinson's Disease: The Potential Mediating Roles of Anxiety and Depression

Kwok JYY, Choi EPH, Lee JJ, Lok KYW, Kwan JCY, Mok VCT, Auyeung M.
Ann Behav Med. 2022 Apr 23:kaac005. doi: 10.1093/abm/kaac005. Epub ahead of print. PMID: 35460239.

Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk

Cao H, Zhou X, Chen Y, Ip FCF, Chen Y, Lai NCH, Lo RMN, Tong EPS, Mok VCT, Kwok TCY; Alzheimer’s Disease Neuroimaging Initiative, Fu AKY, Ip NY
J Alzheimers Dis. 2022;86(4):1861-1873. doi: 10.3233/JAD-215311. PMID: 35253752.

Cost-Effectiveness of Monitoring Patients Post-Stroke With Mobile ECG During the Hospital Stay

Gao L, Moodie M, Freedman B, Lam C, Tu H, Swift C, Ma SH, Mok VCT, Sui Y, Sharpe D, Ghia D, Jannes J, Davis S, Liu X, Yan B.
J Am Heart Assoc. 2022 Apr 19;11(8):e022735. doi: 10.1161/JAHA.121.022735. Epub 2022 Apr 12. PMID: 35411782.

Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution

Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng J, Xie C, Chen H, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV, Zhang L, Wu WKK
Cancer research. 2022 Apr 15;82(8):1482-1491. doi: 10.1158/0008-5472.CAN-21-3458. PMID: 35247889.

Evaluation of oropharyngeal deglutitive pressure dynamics in patients with Parkinson's disease

Szczesniak MM, Omari TI, Lam TY, Wong M, Mok VCT, Wu JCY, Chiu PWY, Yuen MTY, Tsang RK, Cock C, Sung JJ, Wu P.
Am J Physiol Gastrointest Liver Physiol. 2022 Apr 1;322(4):G421-G430. doi: 10.1152/ajpgi.00314.2021. Epub 2022 Feb 9. PMID: 35138164.

Single-cell analysis of microglial transcriptomic diversity in subarachnoid hemorrhage

Chen J, Sun L, Lyu H, Zheng Z, Lai H, Zhang Y, Luo Y, Lu G, Chan WY, Wang Y, Chen X, Li Z, Ko H, Wong KCG
Clin Transl Med. 2022 Apr;12(4):e783. doi: 10.1002/ctm2.783. PMID: 35452189; PMCID: PMC9029016.

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.

Jansen WJ … Mok VCT … Zetterberg H
JAMA Neurol. 2022 Mar 1;79(3):228-243. doi: 10.1001/jamaneurol.2021.5216. Erratum in: JAMA Neurol. 2022 Mar 1;79(3):313. PMID: 35099509.

Large-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity

Tang S, Wang Y, Liu Y, Chau SW, Chan JW, Chu WC, Abrigo JM, Mok VC, Wing YK.
EBioMedicine. 2022 Mar;77:103915. doi: 10.1016/j.ebiom.2022.103915. Epub 2022 Mar 5. PMID: 35259574; PMCID: PMC8904227.

What does aducanumab treatment of Alzheimer's disease mean for research on vascular cognitive disorders?

Wallin A, Alladi S, Black SE, Chen C, Greenberg SM, Gustafson D, Isaacs JD, Jokinen H, Kalaria R, Mok V, Pantoni L, Pasquier F, Roman GC, Rosenberg GA, Schmidt R, Smith EE, Hainsworth AH
Cerebral circulation - cognition and behavior. 2022 Feb 11;3:100044. doi: 10.1016/j.cccb.2022.100044.

Intracranial Arterial Calcification and Intracranial Atherosclerosis: Close but Different

Du H, Li J, Yang W, Bos D, Zheng L, Wong LKS, Leung TW, Chen X
Front Neurol. 2022 Feb 8;13:799429. doi: 10.3389/fneur.2022.799429. PMID: 35211084; PMCID: PMC8861312.

Barriers to generic antiseizure medication use: Results of a global survey by the International League Against Epilepsy Generic Substitution Task Force

Niyongere J, Welty TE, Bell MW, Consalvo D, Hammond C, Leung H, Patsalos PN, Ryan M, Suansanae T, Zhou D, Zuellig H
Epilepsia Open. 2022;00:1– 11.

EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease

Liu N, Tang J, Xue Y, Mok V, Zhang M, Ren X, Wang Y, Fu J
Aging Dis. 2022 Feb 1;13(1):313-328. doi: 10.14336/AD.2021.0627. PMID: 35111376; PMCID: PMC8782563.

Endothelial agrin is dispensable for normal and tumor angiogenesis

Ye P, Fu Z, Chung JYF, Cao X, Ko H, Tian XY, Tang PMK, Lui KO
Frontiers in Cardiovascular Medicine. 2022 Jan 31;doi: 10.3389/fcvm.2021.810477.

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson's disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial

Yuen SCS, Chua KK, Zhong LLD, Chan KW, Chan CKH, Chan KL, Lin Z, Mok V, Lau AY, Li M
Chin Med. 2022 Jan 24;17(1):16. doi: 10.1186/s13020-022-00572-0. PMID: 35073963; PMCID: PMC8785505.

Effects of functional task exercise on everyday problem-solving ability and functional status in older adults with mild cognitive impairment-a randomised controlled trial

Law LLF, Mok VCT, Yau MKS, Fong KNK
Age Ageing. 2022 Jan 6;51(1):afab210. doi: 10.1093/ageing/afab210. PMID: 34673918.

Vitamin D3 and carbamazepine protect against Clostridioides difficile infection by restoring macrophage lysosome acidification

Chan H, Li Q, Wang X , Liu W, Hu W, Zeng J, Kwong T, Ho I, Liu X, Yu Y, Ko H, Chan R, Ip M, Gin T, Cheng A , Zhang L, Chan MTV , Wong SH, Wu WKK
Autophagy. 2022 Jan 6;doi:10.1080/15548627.2021.2016004.

Vertebrobasilar Junction Angle Over 90°: A Potential Imaging Marker Associated With Vertebrobasilar Atherosclerosis

Li J, Yang WJ, Zheng L, Du H, Chu WC, Leung TW, Chen XY
Front Neurosci. 2022 Jan 5;15:789852. doi: 10.3389/fnins.2021.789852. PMID: 35069103; PMCID: PMC8766791.

Primary stroke prevention worldwide: translating evidence into action.

Owolabi MO, Thrift AG, Mahal A, Ishida M, Martins S, Johnson WD, Pandian J, Abd-Allah F, Yaria J, Phan HT, Roth G, Gall SL, Beare R, Phan TG, Mikulik R, Akinyemi RO, Norrving B, Brainin M, Feigin VL; Stroke Experts Collaboration Group
Lancet Public Health. 2022 Jan;7(1):e74-e85. doi: 10.1016/S2468-2667(21)00230-9

Bell’s palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study

Wan EYF, Chui CSL, Lai FTT, Chan EWY, Xue Li, Yan VKC, Gao L, Yu Q, Lam ICH, Chun RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK
Lancet Infect Dis. 2022; 22: 64–72.

2021

Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial

WONG A, LAM BYK, MAK MKY, LAM LCW, AU LWC, YIU BKF, WONG C, TONG HY, YEUNG SK, CHU WCW, SHI L, LEUNG TWH, SOO YOY, LAU AYL, IP BYM, KWOK TCY, KO H, MOK VCT.
Alzheimer’s Dement. 2021;7:e12224.

Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion

Nie X, Wang D, Pu Y, Wei Y, Lu Q, Yan H, Liu X, Zheng L, Liu J, Yang X, Ding Y, Liu D, Duan W, Zhang Z, Yang Z, Wen M, Gu W, Hou X, Leng X, Pan Y, Miao Z, Liu L(corresponding author)
Stroke Vasc Neurol. 2021;0. doi:10.1136/ svn-2021-001242

Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer's disease

Li Z, Ip B, Mok VCT, Ko H
Neural Regen Res. 2021 Dec;16(12):2411-2412. doi: 10.4103/1673-5374.313042.

Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease

de Brito Robalo BM, Biessels GJ, Chen C, Dewenter A, Duering M, Hilal S, Koek HL, Kopczak A, Yin Ka Lam B, Leemans A, Mok V, Onkenhout LP, van den Brink H, de Luca A.
Neuroimage Clin. 2021;32:102886. doi: 10.1016/j.nicl.2021.102886.

Cricopharyngeal peroral endoscopic myotomy improves oropharyngeal dysphagia in patients with Parkinson's disease

Wu PI, Szczesniak MM, Omari T, Lam TY, Wong M, Maclean J, Ma KK, Chan AY, Mok V, Cook IJ, Cock C, Sung J, Wu J, Chiu PW
Endosc Int Open. 2021 Nov 12;9(11):E1811-E1819. doi: 10.1055/a-1562-7107. PMID: 34790549; PMCID: PMC8589553.

Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study

Wang J; Chau SWH, Lam SP, Liu YP, Zhang JH, Chan NY, Cheung MMS, Yu MWM, Tsang JCT, Chan JWY, Huang B, Li SX, Mok V, Wing YK
Journal of Neurology Neurosurgery and Psychiatry. 11 Nov 2021.

The state of stroke services across the globe: Report of World Stroke Organization-World Health Organization surveys

Owolabi MO, Thrift AG, Martins S, Johnson W, Pandian J, Abd-Allah F, Varghese C, Mahal A, Yaria J, Phan HT, Roth G, Gall SL, Beare R, Phan TG, Mikulik R, Norrving B, Feigin VL; Stroke Experts Collaboration Group
Int J Stroke. 2021 Oct;16(8):889-901. doi: 10.1177/17474930211019568.

Magnetic navigation of collective cell microrobots in blood under ultrasound Doppler imaging

Wang Q, Tian Y, Du X, Ko H, Ip BYM, Leung TWH, Yu SCH, Zhang L
IEEE/ASME Transactions on Mechatronics. 2021 Sep 23; (99):1-12. doi:10.1109/TMECH.2021.3109346.

Comparison of Newtonian and Non-newtonian Fluid Models in Blood Flow Simulation in Patients With Intracranial Arterial Stenosis

Liu H, Lan L, Abrigo J, Ip HL, Soo Y, Zheng D, Wong KS, Wang D, Shi L, Leung TW, Leng X
Front Physiol. 2021 Sep 6;12:718540. doi: 10.3389/fphys.2021.718540.

Deep-Learning-Based Pre-Diagnosis Assessment Module for Retinal Photographs: A Multicenter Study

Yuen V, Ran A, Shi J, Sham K, Yang D, Chan VTT, Chan R, Yam JC, Tham CC, McKay GJ, Williams MA, Schmetterer L, Cheng CY, Mok V, Chen CL, Wong TY, Cheung CY
Transl Vis Sci Technol. 2021 Sep 1;10(11):16. doi: 10.1167/tvst.10.11.16. PMID: 34524409; PMCID: PMC8444486.

Reconfigurable magnetic microswarm for accelerating tPA-mediated thrombolysis under ultrasound imaging

Wang Q, Jin D, Wang B, Xia N, Ko H, Ip BYM, Leung TWH, Yu SCH, Zhang L
IEEE/ASME Transactions on Mechatronics. 2021 Aug 11;doi:10.1109/TMECH.2021.3103994.

International Survey of Mechanical Thrombectomy Stroke Systems of Care During COVID-19 Pandemic

Yavagal DR, Saini V, Inoa V, Gardener HE, Martins SO, Fakey M, Ortega S, Mansour O, Leung T, Al-Mufti F, Jadhav AP, Potter-Vig J, Mairal A, Zhongrong M, Sylaja PN, Demchuk AM; MT2020 Global Executive Committee
J Stroke Cerebrovasc Dis. 2021 Aug;30(8):105806. doi: 10.1016/j.jstrokecerebrovasdis.2021.105806.

Understanding the Clinical Implications of Intracranial Arterial Calcification Using Brain CT and Vessel Wall Imaging

Yang WJ, Wasserman BA, Zheng L, Huang ZQ, Li J, Abrigo J, Wong SS, Ying MT, Chu WC, Wong LK, Leung TW and Chen XY.
Front Neurol . 15 July 2021. DOI: 10.3389/fneur.2021.619233.

Global impact of COVID-19 on stroke care

Nogueira RG … Leung T… Nguyen TN.
Int J Stroke. . 2021 Jul;16(5):573-584. doi: 10.1177/1747493021991652

A prediction of hematoma expansion in hemorrhagic patients using a novel dual-modal machine learning strategy

Cheng X, Zhang W, Wu ML, Jiang N, Guo ZN, Leng X, Song JN, Jin H, Sun X, Zhang F, Qin J, Yan X, Cai Z, Luo Y, Yang Y, Liu J
Physiol Meas. 2021 Jul 1. doi: 10.1088/1361-6579/ac10ab. Online ahead of print.

Retinal imaging in Alzheimer’s disease

Cheung CY, Mok V, Foster PJ, Trucco E, Chen C, Wong TY
J Neurol Neurosurg Psychiatry . 2021;92:983–994.

Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

Nogueira RG … Leung T… Nguyen TN.
Neurology. 2021 Jun 8;96(23):e2824-e2838. doi: 10.1212/WNL.0000000000011885.

Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images

Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee A, Kwok C, Lai M, Mok V, Lau A
Brain Commun. 2021 Jun 3;3(3):fcab124. doi: 10.1093/braincomms/fcab124. PMID: 34222872; PMCID: PMC8249101.

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H
Communications Biology. 2021 Jun 2;4(1)656.

High burden of cerebral white matter lesion in 9 Asian cities

Lam BYK, Yiu B, Ampil E, Chen CL, Dikot Y, Dominguez JC, Ganeshbhai PV, Hilal S, Kandiah N, Kim S, Lee JY, Ong AP, Senanarong V, Leung KT, Wang H, Yang YH, Yong T, Arshad F, Alladi S, Wong S, Ko H, Lau AYL, Mok VCT
Sci Rep. 2021 Jun 2;11(1):11587. doi: 10.1038/s41598-021-90746-x.

Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease

Au CKF, Abrigo J, Liu C, Liu W, Lee J, Au LWC, Chan Q, Chen S, Leung EYL, Ho CL, Ko H, Mok VCT, Chen W
J Magn Reson Imaging. 2021 Jun;53(6):1823-1832. doi: 10.1002/jmri.27464.

Super-refractory status epilepticus in autoimmune encephalitis treated with interleukin-1 receptor antagonist, anakinra

Choi CH, Ma SH, Ma KK, Leung H, Mok VC
Epileptic Disord. 2021 Jun 1;23(3):500-505. doi: 10.1684/epd.2021.1283.

Validation of a translated Chinese version of the Participation Strategies Self-Efficacy Scale: a cross-sectional study

Chau JPC, Lo SHS, Zhao J, Choi KC, Lam SKY, Saran R, Shi J, Thompson DR, Lau AYL
Disabil Rehabil. 2021 Jun 1:1-7. doi: 10.1080/09638288.2021.1933220.

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol. 2021 Jun;20(6):448-459. doi: 10.1016/S1474-4422(21)00060-0.

Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL
ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186.

MRI-based Alzheimer's disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer's disease

Liu W, Au LWC, Abrigo J, Luo Y, Wong A, Lam BYK, Fan X, Kwan PWL, Ma HW, Ng AYT, Chen S, Leung EYL, Ho CL, Wong SHM, Chu WC, Ko H, Lau AYL, Shi L, Mok VCT; Alzheimer’s Disease Neuroimaging Initiative
Aging (Albany NY). 2021 May 25;13(10):13496-13514. doi: 10.18632/aging.203082. . https://pubmed.ncbi.nlm.nih.gov/34091443/

Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NCH, Cheung K, Lo RMN, Tong EPS, Wong BWY, Chan ALT, Mok VCT, Kwok TCY, Mok KY, Hardy J, Zetterberg H, Fu AKY, Ip NY
Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12369.

Erratum

Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai MC, Pantoni L, Sachdev P, Senanarong V, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P
Alzheimers Dement. 2021 May;17(5):906-907. doi: 10.1002/alz.12307.

Neurological diseases and risk of mortality in patients with COVID-19 and SARS: a territory-wide study in Hong Kong

Fan FSY, Yip TCF, Yiu B, Lam B, Au L, Lau AYL, Ip B, Soo Y, Leung TWH, Li T, Lui G, Wong GLH, Mok VCT
J Neurol Neurosurg Psychiatry. 2021 Apr 27;jnnp-2021-326286.

Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients

Chan KL, Feng X, Ip B, Huang S, Ma SH, Fan FSY, Ip HL, Huang L, Mok VCT, Soo YOY, Leung TW, Leng X
Front Aging Neurosci. 2021 Apr 20;13:646961. doi: 10.3389/fnagi.2021.646961.

Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir

Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony K. N. Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C. T. Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, and Wai-Lung Ng
ACS Cent Sci. 2021 April 15;doi.org/10.1021/acscentsci.0c01186.

Evolving ischemic stroke subtypes in 15 years: A hospital-based observational study

Ip B, Au L, Chan AYY, Fan F, Ip V, Ma SH, Ma K, Mok VCT, Lau A, Leng X, Leung H, Wong A, Abrigo J, Wong J, Yu S, Wong KS, Soo YOY, Leung TWH
Int J Stroke. 2021 Apr 7;17474930211005953. doi: 10.1177/17474930211005953.

Prevalence and predictors of mood disturbances in idiopathic REM sleep behaviour disorder

Chiu NKH, Ehgoetz Martens KA, Mok VCT, Lewis SJG, Matar E
J Sleep Res. . 2021 Apr;30(2):e13040. doi: 10.1111/jsr.13040.

A Data-Driven Approach to Transfer Function Analysis for Superior Discriminative Power: Optimized Assessment of Dynamic Cerebral Autoregulation

Liu J, Guo ZN, Simpson D, Zhang P, Liu C, Song JN, Leng X, Yang Y
IEEE J Biomed Health Inform. 2021;25:909-921.

Development of image-based risk scores for prediction of intracranial hemorrhage and ischemic stroke in patients taking antithrombotic therapy after ischemic stroke or transient ischemic attack: a pooled analysis of individual patient data from cohort studies

Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sanchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Ben Assayag E, Hallevi H, Molad J, Nishihara M, Tanaka J, Coutts SB, Polymeris A, Wagner B, Seiffge DJ, Lyrer P, Algra A, Kappelle LJ, Al-Shahi Salman R, Jäger HR, Lip GYH, Fischer U, El-Koussy M, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Mess WH, Nederkoorn PJ, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra AC, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, Hendrikse J, Kelly PJ, Wardlaw J, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Hara H, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network
Lancet Neurol. 2021 Apr;20(4):294-303. doi: 10.1016/S1474-4422(21)00024-7.

Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry

Jia B, Ren Z, Mokin M, Burgin WS, Bauer CT, Fiehler J, Mo D, Ma N, Gao F, Huo X, Luo G, Wang A, Pan Y, Song L, Sun X, Zhang X, Gui L, Song C, Peng Y, Wu J, Zhao S, Zhao J, Zhou Z, Li Y, Jing P, Yang L, Liu Y, Zhao Q, Liu Y, Peng X, Gao Q, Guo Z, Chen W, Li W, Cheng X, Xu Y, Zhang Y, Zhang G, Lu Y, Lu X, Wang D, Wang Y, Li H, Ling L, Peng G, Zhang J, Zhang K, Li S, Qi Z, Xu H, Tong X, Ma G, Liu R, Guo X, Deng Y, Leng X, Leung TW, Liebeskind DS, Wang Y, Wang Y, Miao Z; ANGEL-ACT Study Group
Stroke. 2021 Apr;52(4):1203-1212. doi: 10.1161/STROKEAHA.120.031869.

Recommendation to Use Wearable-Based mHealth in Closed-Loop Management of Acute Cardiovascular Disease Patients During the COVID-19 Pandemic

Ji N, Xiang T, Bonato P, Lovell NH, Ooi SY, Clifton DA, Akay M, Ding XR, Yan BP, Mok V, Fotiadis DI, Zhang YT
IEEE J Biomed Health Inform. 2021 Apr;25(4):903-908. doi: 10.1109/JBHI.2021.3059883. Epub 2021 Apr 6. PMID: 33596179.

Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review

Leng XY, Hurford R, Feng XY, Chan KY, Wolters FJ, Li LX, Soo YOY, Wong LKS, Mok VCT, Leung TWH, Rothwell PM
J Neurol Neurosurg Psychiatry. 2021 Mar 30; doi: 10.1136/jnnp-2020-325630.

Teaching Video NeuroImages: A Triad of Tremor, Ataxia, and Cognitive Impairment

Au LWC, Ho K, Li JJX, Mok VCT
Neurology. 2021 Mar 30;96(13):e1802-e1803. doi: 10.1212/WNL.0000000000011288.

Endoscopy-assisted magnetic navigation of biohybrid soft microrobots with rapid endoluminal delivery and imaging

Wang B, Chan KF, Yuan K, Wang Q, Xia X, Yang L, Ko H, Wang YXJ, Sung JJY, Chiu PWY, Zhang L
Sci Robot. 2021 Mar 17;6(52):eabd2813. doi: 10.1126/scirobotics.abd2813. PMID: 34043547.

A retrospective comparison of cognitive performance in individuals with advanced Parkinson's Disease in Hong Kong and Canada

Kwan V, Shum D, Haffenden A, Yeates KO, Kwok A, Lau H, Poon WS, Chan D, Zhu XL, Chan D, Mok V, Chan A, Ma K, Yeung J, Lau C, Bezchlibnyk Y, Kiss Z, Tang V
Appl Neuropsychol Adult. 2021 Mar 15:1-9. doi: 10.1080/23279095.2021.1898396.

Intraluminal Thrombus and Outcomes of Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Treatment

Ding Y, Leng X, Nie X, Pan Y, Li J, Liu D, Yan H, Pu Y, Wei Y, Cai Y, Lu Q, Zhang Z, Duan W, Gu W, Hou X, Yang Z, Wen M, Ma N, Miao Z, Wang Y, Liu L, and on behalf of the RESCUE-RE Study Group
Stroke. 2021;52:1473–1477.

Dabigatran or Aspirin in East Asian Patients With Embolic Stroke of Undetermined Source: RE-SPECT ESUS Subgroup Analysis

Uchiyama S, Toyoda K, Lee BC, Liou CW, Wong LKS, Grauer C, Brueckmann M, Taniguchi A, Urano Y, Easton JD; RE-SPECT ESUS Investigators
Stroke. 2021 Mar;52(3):1069-1073. doi: 10.1161/STROKEAHA.120.031891.

High-Degree Middle Cerebral Artery Stenosis : Can Advanced 3D DSA-MRI Fusion Imaging Better Illustrate Plaques and Perforators?

Guan M, Lin J, Huang S, Leng X, Shi C, Qiao H, Wang X, Huang L
Clin Neuroradiol. 2021 Mar;31(1):51-59. doi: 10.1007/s00062-020-00927-w.

Adverse Outcomes Associated With Higher Mean Blood Pressure and Greater Blood Pressure Variability Immediately After Successful Embolectomy in Those With Acute Ischemic Stroke, and the Influence of Pretreatment Collateral Circulation Status

Liu D, Nie X, Pan Y, Yan H, Pu Y, Wei Y, Cai Y, Ding Y, Lu Q, Zhang Z, Gu W, Hou X, Yang Z, Wen M, Wang P, Ma G, Ma N, Miao Z, Leng X, Yan B, Davis SM, Wang Y, Liu L
J Am Heart Assoc. 2021 Feb;10(5):e019350. doi: 10.1161/JAHA.120.019350.

Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis

Duan J, Leng X, Han Z, Cai Y, Wang C, Rajah G, Song H, Ding Y, Ji X
Aging Dis. 2021 Feb 1;12(1):93-101. doi: 10.14336/AD.2020.0405.

Effects of wearable ankle robotics for stair and over-ground training on sub-acute stroke: a randomized controlled trial

Yeung LF, Lau CCY, Lai CWK, Soo YOY, Chan ML, Tong RKY
J Neuroeng Rehabil. 2021 Jan 29;18(1):19. doi: 10.1186/s12984-021-00814-6.

Modulation of Functional Connectivity and Low-Frequency Fluctuations After Brain-Computer Interface-Guided Robot Hand Training in Chronic Stroke: A 6-Month Follow-Up Study.

Lau CCY, Yuan K, Wong PCM, Chu WCW, Leung TW, Wong WW, Tong RKY
2021 Jan 20;14:611064. doi: 10.3389/fnhum.2020.611064. . Front Hum Neurosci

Correction: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study

Chan J, Wong A, Yiu B, Mok H, Lam P, Kwan P, Chan A, Mok VCT, Tsoi KKF, Kwok TCY
J Med Internet Res. 2021 Jan 19;23(1):e26724. doi: 10.2196/26724.

Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research

Ng KP, Chiew HJ, Hameed S, Ting SKS, Ng A, Soo SA, Wong BYX, Lim L, Yong ACW, Mok VCT, Rosa-Neto P, Dominguez J, Kim S, Hsiung GYR, Ikeda M, Miller BL, Gauthier S, Kandiah N
Alzheimers Dement (N Y). 2021 Jan 15;6(1):e12085. doi: 10.1002/trc2.12085.

Predictors of survival in frontotemporal lobar degeneration syndromes

El-Wahsh S, Finger EC, Piguet O, Mok V, Rohrer JD, Kiernan MC, Ahmed RM
J Neurol Neurosurg Psychiatry. 2021 Jan 13:jnnp-2020-324349. doi: 10.1136/jnnp-2020-324349.

An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer's disease

Yu Q, Mai Y, Ruan Y, Luo Y, Zhao L, Fang W, Cao Z, Li Y, Liao W, Xiao S, Mok VCT, Shi L, Liu J; National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Neuroimaging Initiative; Frontotemporal Lobar Degeneration Neuroimaging Initiative
Alzheimers Res Ther. 2021 Jan 12;13(1):23. doi: 10.1186/s13195-020-00757-5.

Plaque Wall Distribution Pattern of the Atherosclerotic Middle Cerebral Artery associates with the Circle of Willis Completeness

Li J, Zheng L, Yang WJ, Sze-To CY, Leung TW, Chen XY
Front Neurol. 2021 Jan 11;11:599459. doi: 10.3389/fneur.2020.599459.

Pandemic of the aging society - sporadic cerebral small vessel disease

Lau AYL, Ip BYM, Ko H, Lam BYK, Shi L, Ma KKY, Au LWC, Soo YOY, Leung TWH, Wong A, Mok VCT
Chin Med J (Engl). 2021 Jan 5;134(2):143-150. doi: 10.1097/CM9.0000000000001320.

AD Resemblance Atrophy Index as a Diagnostic Biomarker for Alzheimer's Disease: A Retrospective Clinical and Biological Validation

Mai Y, Yu Q, Zhu F, Luo Y, Liao W, Zhao L, Xu C, Fang W, Ruan Y, Cao Z, Lei M, Au L, Mok VCT, Shi L, Liu J
J Alzheimers Dis. 2021;79(3):1023-1032. doi: 10.3233/JAD-201033.

High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders

Liu C, Zhao L, Fan P, Ko H, Au C, Ng A, Au L, Wong A, Kermode AG, Mok V, Yan Y, Qiu W, Lau AY
J Clin Neurosci. 2021 Jan;83:108-111. doi: 10.1016/j.jocn.2020.11.016.

2020

Intracranial Atherosclerosis Coexisting With White Matter Hyperintensities May Predict Unfavorable Functional Outcome in Patients With Acute Cerebral Ischemia

Liu H, Pu Y, Wang Y, Zou X, Pan Y, Zhang C, Soo YOY, Leung TWH, Zhao X, Wong KSL, Wang Y, Liu L
Front Neurol. 2020 Dec 21;11:609607. doi: 10.3389/fneur.2020.609607. eCollection 2020.

Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study

Chan JYC, Wong A, Yiu B, Mok H, Lam P, Kwan P, Chan A, Mok VCT, Tsoi KKF, Kwok TCY
J Med Internet Res. 2020 Dec 18;22(12):e17332. doi: 10.2196/17332.

Magnetic resonance imaging manifestations of cerebral small vessel disease: automated quantification and clinical application

Zhao L, Lee A, Fan YH, Mok VCT, Shi L
Chin Med J (Engl). 2020 Dec 16;134(2):151-160. doi: 10.1097/CM9.0000000000001299. PMID: 33443936; PMCID: PMC7817342.

High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders

Liu C, Zhao L, Fan P, Ko H, Au C, Ng A, Au L, Wong A, Kermode AG, Mok V, Yan Y, Qiu W, Lau AY
J Clin Neurosci. . 2020 Dec 11:S0967-5868(20)31639-8. doi: 10.1016/j.jocn.2020.11.016. Online ahead of print.

Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease

Au CKF, Abrigo J, Liu C, Liu W, Lee J, Au LWC, Chan Q, Chen S, Leung EYL, Ho CL, Ko H, Mok VCT, Chen W
J Magn Reson Imaging. 2020 Dec 9. doi: 10.1002/jmri.27464. Online ahead of print.PMID: 33295658.

Teaching Video Neuroimages: A triad of tremor, ataxia and cognitive impairment

Au LWC, Ho K, Li JJX, Mok VCT
Neurology. 2020 Dec 4:10.1212/WNL.0000000000011288. doi: 10.1212/WNL.0000000000011288. Online ahead of print.

Gastrodia-Uncaria water extract and tissue plasminogen activator for treating embolus-induced cerebral ischaemia: abridged secondary publication

Xian JW, Choi AYT, Leung WN, Li L, Lau CBS, Leung TWH, Chan CW
Hong Kong Med J. 2020 Dec;26 Suppl 7(6):45-47. PMID: 33229620.

Intracranial artery calcification to screen patients at high risk of recurrent stroke: abridged secondary publication

Wong KS, Chen XY, Leung TWH, Siu YW, Xiong L, Leng X
Hong Kong Med J. 2020 Dec;26 Suppl 7(6):42-44. PMID: 33229619.

Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype

Au LWC, Lee HHC, Sheng B, Chan KY, Yau EKC, Mak CM, Chan AYW, Chan AYY, Lau CKY, Mok VCT, Lam CW
Clin Neurol Neurosurg. 2020 Dec;199:106258. doi: 10.1016/j.clineuro.2020.106258. Epub 2020 Sep 30.PMID: 33031988.

Stochastic stimulation of the motor cortex for treating parkinsonian symptoms: abridged secondary publication

Yung WH, Mok VCT, Ke Y.
Hong Kong Med J. . 2020 Dec;26 Suppl 7(6):23-25.

Plaque morphology in acute symptomatic intracranial atheroscleroticdisease

Leung TW, Wang L, Zou X, Soo Y, Pu Y, Ip HL, Chan A, Au LWC, Fan F, Ma SH, Ip B, Ma K, Lau AY, Leung H, Hui KF, Li R, Li SH, Fu M, Fong WC, Liu J, Mok V, Wong KSL, Miao Z, Ma N, Yu SCH, Leng X
J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020- 325027. doi: 10.1136/jnnp-2020-325027.

Effect of microcirculatory resistance on coronary blood flow and instantaneous wave-free ratio: A computational study

Liu H, Ou S, Liu P, Xu Y, Gong Y, Xia L, Leng X, Leung TWH, Shi L, Zheng D
Comput Methods Programs Biomed. 2020 Nov;196:105632. doi: 10.1016/j.cmpb.2020.105632. Epub 2020 Jun 25.

Residual Injurious Symptoms and Its Association With Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-up Study

Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK
Mov Disord. 2020 Nov;35(11):2077-2085. doi: 10.1002/mds.28210. Epub 2020 Aug 3.

Fostering gerontology students' competence in Interprofessional collaborative practice

Chau JPC, Lo SHS, Lee VWY, Yiu WM, Chiang HCY, Thompson DR, Lau AYL
BMC Med Educ. 2020 Oct 27;20(1):388. doi: 10.1186/s12909-020-02273-4.

Hong Kong College of Physicians Position Statement and Recommendations on the 2017 American College of Cardiology/American Heart Association and 2018 European Society ofCardiology/European Society of Hypertension Guidelines for Management of Arterial Hypertension

Chan KK, Szeto CC, Lum CCM, Ng PW, Kong APS, Lau KP, Leung JYY, Lui SL, Mo KL, Mok FCK, Mok VCT, Yan BPY, Li PKT
Hong Kong Med J. 2020 Oct;26(5):432-437. doi: 10.12809/hkmj198330.PMID: 33089788.

Prolonged visual fixation as a surrogate marker of cholinergic deficit in Parkinson's disease: A 2-year follow-up study

Wong OW, Chan A, Wong A, Lau CK, Yeung JH, Mok V, Chan S
Parkinsonism Relat Disord. 2020 Dec;81:60-66. doi: 10.1016/j.parkreldis.2020.10.019. Epub 2020 Oct 11.

Intracranial Arterial Calcification Relates to Long-Term Risk of Recurrent Stroke and Post-stroke Mortality

Wu X, Bos D, Ren L, Leung TW, Chu WC, Wong LKS, Abrigo J, Chen XY
Front Neurol. 2020 Oct 9;11:559158. doi: 10.3389/fneur.2020.559158. PMID: 33162927; PMCID: PMC7581678.

Rest-Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder

Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MWM, Huang B, Li SX, Chau SWH, Chan JWY, Chen J, Mok VCT, Wing YK, Zhang J
Ann Neurol. 2020 Oct;88(4):817-829. doi: 10.1002/ana.25853. Epub 2020 Aug 18.

Regional High Wall Shear Stress Associated With Stenosis Regression in Symptomatic Intracranial Atherosclerotic Disease

Lan L, Liu H, Ip V, Soo Y, Abrigo J, Fan F, Ma SH, Ma K, Ip B, Liu J, Fan Y, Zeng J, Mok V, Wong L, Liebeskind D, Leung T, Leng X
Stroke. 2020 Oct;51(10):3064-3073. doi: 10.1161/STROKEAHA.120.030615. Epub 2020 Sep 4.

Effects of a multidisciplinary team-led school-based human papillomavirus vaccination health-promotion programme on improving vaccine acceptance and uptake among female adolescents: A cluster randomized controlled trial

Chau JPC, Lo SHS, Choi KC, Lee VWY, Lui GCY, Chan KM, Lau AYL
Medicine (Baltimore). 2020 Sep 11;99(37):e22072. doi: 10.1097/MD.0000000000022072.

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

Lei Zhao, Zhongqi Li, Joaquim S L Vong, Xinyi Chen, Hei-Ming Lai, Leo Y C Yan, Junzhe Huang, Samuel K H Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C T Mok, Ho Ko
Nat Commun. 2020 Sep 4;11(1):4413. doi:10.1038/s41467-020-18249-3.

Nurse Led Smartphone Electrographic Monitoring for Atrial Fibrillation after Ischemic Stroke: SPOT-AF

Yan B, Tu H, Lam C, Swift C, Ma SH, Mok VCT, Sui Y, Sharpe D, Ghia D, Jannes J, Davis S, Liu X, Freedman B
J Stroke. 2020 Sep;22(3):387-395. doi: 10.5853/jos.2020.00689. Epub 2020 Sep 29.PMID: 33053954.

Advanced MRI features in relapsing multiple sclerosis patients with and without CSF oligoclonal IgG bands

Zhao L, Abrigo J, Chen Q, Au C, Ng A, Fan P, Mok V, Qiu W, Kermode AG, Lau AY
Sci Rep. 2020 Aug 13;10(1):13703. doi: 10.1038/s41598-020-70693-9. PMID: 32792656; PMCID: PMC7426866.

Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future

Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath P, GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim SY, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P
Alzheimer's & Dementia. 2020 Aug 12;doi:10.1002/alz.12143

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population

Zhou X, Chen Y, Ip FCF, Lai NCH, Li YYT, Jiang Y, Zhong H, Chen Y, Zhang Y, Ma S, Lo RMN, Cheung K, Tong EPS, Ko H, Shoai M, Mok KY, Hardy J, Mok VCT, Kwok TCY, Fu AKY, Ip NY
Alzheimers Dement (Amst). 2020 Aug 5;12(1):e12074. doi: 10.1002/dad2.12074. eCollection 2020.PMID: 32775599.

Lipid-Bilayer-Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions

Zhou L, Wolfes AC, Li Y, Chan DCW, Ko H, Szele FG, Bayley H
Adv Mater. 2020 Aug;32(31):e2002183. doi: 10.1002/adma.202002183. Epub 2020 Jun 14. PMID: 32537827.

Regression of Plaque Enhancement Within Symptomatic Middle Cerebral Artery Atherosclerosis: A High-Resolution MRI Study

Yang WJ, Abrigo J, Soo YO, Wong S, Wong KS, Leung TW, Chu WC, Chen XY.
Front Neurol. 2020 Jul 28;11:755. doi: 10.3389/fneur.2020.00755

High White Matter Hyperintensity Burden in Strategic White Matter Tracts Relates to Worse Global Cognitive Performance in Community-Dwelling Individuals

BIESBROEK JM, LAM BYK, ZHAO L, TANG Y, WANG Z, ABRIGO J, CHU WWC, WONG A, SHI L, KUIJF HJ, BIESSELS GJ, MOK VCT
J Neurol Sci. 2020 Jul 15;414:116835. doi: 10.1016/j.jns.2020.116835. Epub 2020 Apr 13.

Dataset on blood flow and instantaneous wave-free ratio in normal and stenosed coronary arteries

Liu H, Ou S, Liu P, Xu Y, Gong Y, Xia L, Leng X, Leung TWH, Shi L, Zheng D
Data Brief. 2020 Jul 11;32:106011. doi: 10.1016/j.dib.2020.106011. eCollection 2020 Oct.

State-of-the-art Computational Models of Circle of Willis with Physiological Applications: A Review

Liu H, Wang D, Leng X, Zheng D, Chen F, Wong LKS, Shi L, Leung TWH
IEEE Access. 2020 Jul; 8:156261-156273. doi: 10.1109/ACCESS.2020.3007737.

Impaired cognition is related to microstructural integrity in relapsing remitting multiple sclerosis

Zhao L, Ng A, Chen Q, Lam B, Abrigo J, Au C, Mok VCT, Wong A, Lau AY
Ann Clin Transl Neurol. 2020 Jul;7(7):1193-1203. doi: 10.1002/acn3.51100. Epub 2020 Jun 9. PMID: 32519512; PMCID: PMC7359116.

Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts

Tang EYH, Price CI, Robinson L, Exley C, Desmond DW, Köhler S, Staals J, Yin Ka Lam B, Wong A, Mok V, Bordet R, Bordet AM, Dondaine T, Lo JW, Sachdev PS, Stephan BCM; STROKOG Collaboration
Stroke. 2020 Jul;51(7):2095-2102. doi: 10.1161/STROKEAHA.120.027473. Epub 2020 Jun 17.

Impaired Cognition Is Related to Microstructural Integrity in Relapsing Remitting Multiple Sclerosis

ZHAO L, NG A, CHEN Q, LAM B, ABRIGO J, AU C, MOK VCT, WONG A, LAU AY
Ann Clin Transl Neurol. 2020 Jun 9. doi: 10.1002/acn3.51100. Online ahead of print.

Risk of COVID-19 infection in MS and neuromyelitis optica spectrum disorders

Fan M, Qiu W, Bu B, Xu Y, Yang H, Huang D, Lau AY, Guo J, Zhang MN, Zhang X, Yang CS, Chen J, Zheng P, Liu Q, Zhang C, Shi FD
Neurol Neuroimmunol Neuroinflamm. 2020 Jun 4;7(5):e787. doi: 10.1212/NXI.0000000000000787. PMID: 32503092; PMCID: PMC7286663.

Decreased Visible Deep Medullary Veins Is a Novel Imaging Marker for Cerebral Small Vessel Disease

CHEN X, WEI L, WANG J, SHAN Y, CAI W, MEN X, LIU S, KANG Z, LU Z, MOK VCT, WU A
Neurol Sci. 2020 Jun;41(6):1497-1506. doi: 10.1007/s10072-019-04203-9. Epub 2020 Jan 18.

Risk of COVID-19 infection in MS and neuromyelitis optica spectrum disorders

Fan M, Qiu W, Bu B, Xu Y, Yang H, Huang D, Lau AY, Guo J, Zhang MN, Zhang X, Yang CS, Chen J, Zheng P, Liu Q, Zhang C, Shi FD
Neurol Neuroimmunol Neuroinflamm. 2020 Jun 4;7(5):e787. doi: 10.1212/NXI.0000000000000787.

Herb-Drug Interaction of Gastrodiae Rhizoma on Carbamazepine: A Pharmacokinetic Study in Rate

YIP KL, ZHOU X, CHOOK P, LEUNG PC, SCHACHTER S, MOK VCT, LEUNG TWH, KOON CM, LEUNG H
Epilepsy Res. 2020 May 31; 165. doi: 10.1016/j.eplepsyres.2020.106376

Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults

Wong A, Lou W, Ho KF, Yiu BK, Lin S, Chu WC, Abrigo J, Lee D, Lam BY, Au LW, Soo YO, Lau AY, Kwok TC, Leung TW, Lam LC, Ko H, Mok VCT
Sci Rep. 2020 Apr 27;10(1):7090. doi: 10.1038/s41598-020-63568-6.

Translesional Pressure Gradient Alters Relationship Between Blood Pressure and Recurrent Stroke in Intracranial Stenosis

FENG X, CHAN KL, LAN L, ABRIGO J, IP VHL, SOO YOY, LEUNG TW, LENG X
Stroke. 2020 Jun;51(6):1862-1864. doi: 10.1161/STROKEAHA.119.028616. Epub 2020 Apr 21.

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study

FOO JN, CHEW EGY, CHUNG SJ, PENG R, BLAUWENDRAAT C, NALLS MA, MOK KY, SATAKE W, TODA T, CHAO Y, TAN LCS, TANDIONO M, LIAN MM, NG EY, PRAKASH KM, AU WL, MEAH WY, MOK SQ, ANNUAR AA, CHAN AYY, CHEN L, CHEN Y, JEON BS, JIANG L, LIM JL, LIN JJ, LIU C, MAO C, MOK V, PEI Z, SHANG HF, SHI CH, SONG K, TAN AH, WU YR, XU YM, XU R, YAN Y, YANG J, ZHANG B, KOH WP, LIM SY, KHOR CC, LIU J, TAN EK
JAMA Neurol. 2020 Apr 20;e200428. doi: 10.1001/jamaneurol.2020.0428.

Hemodynamic Significance of Middle Cerebral Artery Stenosis Associated With the Severity of Ipsilateral White Matter Changes

FANG H, LENG X, PU Y, ZOU X, PAN Y, SONG B, SOO YOY, LEUNG TWH, WANG C, ZHAO X, WANG Y, WANG Y, WONG KS, LIU L, XU Y, CICAS STUDY GROUP
Front Neurol. 2020 Apr 15;11:214. doi: 10.3389/fneur.2020.00214. eCollection 2020.

Prevalence and Predictors of Mood Disturbances in Idiopathic REM Sleep Behaviour Disorder

CHIU NKH, EHGOETZ MARTENS KA, MOK VCT, LEWIS SJG, MATAR E
J Sleep Res. 2020 Apr 7;e13040. doi: 10.1111/jsr.13040. Online ahead of print.

Stroke Outcome Prediction by Blood Pressure Variability, Heart Rate Variability, and Baroreflex Sensitivity

TANG S, XIONG L, FAN Y, MOK VCT, WONG KS, LEUNG TW
Stroke. 2020 Apr;51(4):1317-1320. doi: 10.1161/STROKEAHA.119.027981. Epub 2020 Jan 22.

Association Between Advanced Interatrial Block and Small Vessel Diseases in the Brain

WANG Z, QIN H, CHEN G, MOK VCT, DAI Y, CAI Y, CHENG X, QIAN Y, CHU M, LU X
Quant Imaging Med Surg. 2020 Mar;10(3):585-591. doi: 10.21037/qims.2020.02.02.

UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment: Questionnaire and Workshop Proceedings

MCFALL A, HIETAMIES TM, BERNARD A, AIMABLE M, ALLAN SM, BATH PM, BREZZO G, CARARE RO, CARSWELL HV, CLARKSON AN, CURRIE G, FARR TD, FOWLER JH, GOOD M, HAINSWORTH AH, HALL C, HORSBURGH K, KALARIA R, KEHOE P, LAWRENCE C, MACLEOD M, MCCOLL BW, MCNEILLY A, MILLER AA, MINERS S, MOK V, O'SULLIVAN M, PLATT B, SENA ES, SHARP M, STRANGWARD P, SZYMKOWIAK S, TOUYZ RM, TRUEMAN RC, WHITE C, MCCABE C, WORK LM, QUINN TJ
J Cereb Blood Flow Metab. 2020 Mar 9;271678X20910552. doi: 10.1177/0271678X20910552. Online ahead of print.

Contra-Directional Expression of Plasma Superoxide Dismutase With Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson's Disease Severity

YANG W, CHANG Z, QUE R, WENG G, DENG B, WANG T, HUANG Z, XIE F, WEI X, YANG Q, LI M, MA K, ZHOU F, TANG B, MOK VCT, ZHU S, WANG Q.
Front Aging Neurosci. 2020 Mar 6;12:53. doi: 10.3389/fnagi.2020.00053. eCollection 2020.

The Role of Cerebral Microbleeds in the Incidence of Post-Stroke Dementia

YATAWARA C, GUEVARRA AC, NG KP, CHANDER R, LAM BYK, WONG A, MOK V, KANDIAH N
J Neurol Sci. 2020 May 15;412:116736. doi: 10.1016/j.jns.2020.116736. Epub 2020 Feb 15.

Pathophysiology of Vascular Cognitive Impairment (II): Amyloid Contribution in Vascular Cognitive Impairment

KO H, LAM BYK, MOK VCT
Stroke Revisited: Vascular Cognitive Impairment.. 2020;87-97. ISBN 978-981-10-1433-8.

Is the future of symptomatic intracranial atherosclerotic stenosis management promising?

Liu D, Liu J, Cai Y, Wong KSL, Liu L
J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):122- 124. doi: 10.1136/jnnp-2019-321564.

Screening for Chronic Conditions With Reproductive Factors Using a Machine Learning Based Approach

TIAN S, DONG W, CHAN KL, LENG X, BEDFORD LE, LIU J
Sci Rep. 2020 Feb 18;10(1):2848. doi: 10.1038/s41598-020-59825-3.

Protocols of Non-Invasive Brain Stimulation for Neuroplasticity Induction

HE W, FONG PY, LEUNG TWH, HUANG YZ
Neurosci Lett. 2020 Feb 6;719:133437. doi: 10.1016/j.neulet.2018.02.045. Epub 2018 Feb 21.

Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial

Liu X, Dai Q, Ye R,… Leung T …, Nogueira RG
Lancet Neurol. 2020 Feb;19(2):115-122. doi: 10.1016/S1474-4422(19)30395-3

Pneumocystis Pneumonia in a Patient Treated With Alemtuzumab for Relapsing Multiple Sclerosis

LAU AY, LUI GCY, CHAN KP, AU C, MOK VCT, ZIEMSSEN T
Mult Scler Relat Disord. 2020 Feb;38:101503. doi: 10.1016/j.msard.2019.101503. Epub 2019 Nov 6.

Characteristics of Wall Shear Stress and Pressure of Intracranial Atherosclerosis Analyzed by a Computational Fluid Dynamics Model: A Pilot Study

CHEN Z, QIN H, LIU J, WU B, CHENG Z, JIANG Y, LIU L, JING L, LENG X, JING J, WANG Y, WANG Y
Front Neurol. 2020 Jan 17;10:1372. doi: 10.3389/fneur.2019.01372. eCollection 2019.

Treatment patterns of patients with multiple sclerosis in Guangzhou, China

Li R, Wang J, Li J, Wang Y, Wu H, Fan P, Lau AY, Kermode A, Qiu W
Neurology Asia. 2020; 25(2):173-182. (IF 0.240)

Dementia in China: Epidemiology, Clinical Management, and Research Advances

JIA L, QUAN M, FU Y,  ZHAO T, LI Y, WEI C, TANG Y, QIN Q, WANG F, QIAO Y, SHI S, WANG YJ, DU Y, ZHANG J, ZHANG J, LUO B, QU Q, ZHOU C, GAUTHIER S, JIA J, ZHOU A, ZUO X, CHU C, YU Y, CHANG H, LI D, GUO D, XING Y, HUANG X, QIU Q, XU H, YAN X, CHEN S, YANG J, LYU J, JIA Z, HUANG Y, JIA J, PENG D, JI Y, GUO Q, CAO Y, SUN L, LI Y, LYU P, GANG B, ZHANG N, TAN L, TANG H, LI H, LIAO Z, LIU J, LU Y, XU J, ZHANG K, SHI X, JI X, LI X, GUO Y, BI J, MOK VCT, KAN M, LI F, ZHOU W, CHU L, YANG S, YANG H, YOU Y
Lancet Neurol. 2020 Jan;19(1):81-92. doi: 10.1016/S1474-4422(19)30290-X. Epub 2019 Sep 4.

Topological Reorganization of the Default Mode Network in Patients With Poststroke Depressive Symptoms: A Resting-State fMRI Study

LIANG Y, YAO YC, ZHAO L, SHI L, CHEN YK, MOK VC, UNGVARI GS, CHU WC, TANG WK
J Affect Disord. 2020 Jan 1;260:557-568. doi: 10.1016/j.jad.2019.09.051. Epub 2019 Sep 11.

Sustaining Cerebral Perfusion in Intracranial Atherosclerotic Stenosis: The Roles of Antegrade Residual Flow and Leptomeningeal Collateral Flow

LAN L, Leng X, IP V, Soo Y, ABRIGO J, LIU H, FAN F, MA SH, MA K, IP BY, CHAN KL, MOK VC, LIEBESKIND DS, WONG KS, LEUNG TW
J Cereb Blood Flow Metab. 2020 Jan;40(1):126-134. doi: 10.1177/0271678X18805209. Epub 2018 Oct 23.

Development of a Delayed Cerebral Infarction Load Scoring System (DCI Score)

WONG GKC, NUNG RCH, SITT JCM, MOK VCT, WONG A, POON WS, WANG D, ABRIGO J, SIU DYW
Acta Neurochir Suppl. 2020;127:145-148. doi: 10.1007/978-3-030-04615-6_21.

2019

Autoimmune Glial Fibillary Acidic Protein Astrocytopathy Associated Meningoencephalomyelitis and Bilateral Sensorineuronal Deafness

IP B, LAM C, IP V, CHAN A, MOK V, AU E, CHAN E, LAU A
Mult Scler Relat Disord. 2020 May;40:101922. doi: 10.1016/j.msard.2019.101922. Epub 2019 Dec 31.

The antiepileptic effect of Gastrodiae Rhizoma through modulating overexpression of mTOR and attenuating astrogliosis in pilocarpine mice model

Yip KL, Koon CM, Chen ZY, Chook P, Leung PC, Schachter S, Leung WH, Mok CT, Leung H
Epilepsia Open. 2019 Dec 13;5(1):50-60. doi: 10.1002/epi4.12372. PMID: 32140643; PMCID: PMC7049815.

A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases

YU AC, YIM AK, CHAN AY, YUEN LYP, AU WC, CHENG THT, LIN X, LI JW, CHAN LWL, MOK VCT, CHAN TF, CHAN HYE
Front Neurosci. 2019 Dec 11;13:1324. doi: 10.3389/fnins.2019.01324. eCollection 2019.

Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups

Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae HJ, Lim JS, Köhler S, Douven E, Staals J, Chen C, Xu X, Chong EJ, Akinyemi RO, Kalaria RN, Ogunniyi A, Barbay M, Roussel M, Lee BC, Srikanth VK, Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema JW, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombois S, Hénon H, Lipnicki DM, Kochan NA, Sachdev PS; Stroke and Cognition (STROKOG) Collaboration
Neurology. 2019 Dec 10;93(24):e2257-e2271. doi: 10.1212/WNL.0000000000008612. Epub 2019 Nov 11. PMID: 31712368; PMCID: PMC6937495.

Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial

Law LLF, Mok VCT, Yau MMK
Alzheimers Res Ther. 2019 Dec 4;11(1):98. doi: 10.1186/s13195-019-0548-2. PMID: 31801630; PMCID: PMC6894271.

Response by Feng Et Al to Letter Regarding Article, "Stroke Mechanisms in Symptomatic Intracranial Atherosclerotic Disease: Classification and Clinical Implications"

FENG X, LEUNG TW, LENG X
Stroke. 2019 Dec;50(12):e437. doi: 10.1161/STROKEAHA.119.027738. Epub 2019 Nov 13.

Neuroimaging in Vascular Parkinsonism

MA KKY, LIN S, MOK VCT
Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):102. doi: 10.1007/s11910-019-1019-7.

Mapping the Patterns of Cortical Thickness in Single- And Multiple-Domain Amnestic Mild Cognitive Impairment Patients: A Pilot Study

SUN P, LOU W, LIU J, SHI L, LI K, WANG D, MOK VC, LIANG P
Aging (Albany NY). 2019 Nov 22;11(22):10000-10015. doi: 10.18632/aging.102362. Epub 2019 Nov 22.

Prevalence and Clinical Correlates of Poststroke Behavioral Dysexecutive Syndrome

TANG WK, LAU CG, LIANG Y, WANG L, MOK V, SOO OYY, LEUNG WHT, UNGVARI GS, UCHIYAMA S, KIM JS
J Am Heart Assoc. 2019 Nov 19;8(22):e013448. doi: 10.1161/JAHA.119.013448. Epub 2019 Nov 7.

Cerebral Small Vessel Disease Burden Is Associated With Accelerated Poststroke Cognitive Decline: A 1-Year Follow-Up Study

LIANG Y, CHEN YK, LIU YL, MOK VCT, UNGVARI GS, CHU WCW, SEO SW, TANG WK
J Geriatr Psychiatry Neurol. 2019 Nov;32(6):336-343. doi: 10.1177/0891988719862630.

Automated Brain MRI Volumetry Differentiates Early Stages of Alzheimer's Disease From Normal Aging

ZHAO W, LUO Y, ZHAO L, MOK V, SU L, YIN C, SUN Y, LU J, SHI L, HAN Y
J Geriatr Psychiatry Neurol. 2019 Nov;32(6):354-364. doi: 10.1177/0891988719862637.

Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors

Lam BYK, Leung KT, Yiu B, Zhao L, Biesbroek JM, Au L, Tang Y, Wang K, Fan Y, Fu JH, Xu Q, Song H, Tian X, Chu WCW, Abrigo J, Shi L, Ko H, Lau A, Duering M, Wong A, Mok VCT
Alzheimer's & dementia (Amsterdam, Netherlands). 2019 Oct 25;11:721-729. doi: 10.1016/j.dadm.2019.09.003. PMID: 31700990; PMCID: PMC6829102.

Stroke mechanisms in symptomatic intracranial atherosclerosis disease

Feng X, Chan KL, Lan L, Abrigo J, Liu J, Fang H, Xu Y, Soo Y, Leng X, Leung TW (corresponding author)
Stroke. 2019 Oct;50(10):2692-2699. doi: 10.1161/STROKEAHA.119.025732.

Neural evidence for long-term marriage shaping the functional brain network organization between couples

Shi L, Lou W, Wong A, Zhang F, Abrigo J, Chu WC, Kwok TC, Wong KK, Abbott D, Wang D, Mok VC.
Neuroimage. 2019 Oct 1;199:87-92. doi: 10.1016/j.neuroimage.2019.05.058. Epub 2019 May 23.

Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study.

NeuroVISION Investigators
Lancet. . 2019 Sep 21;394(10203):1022-1029. doi: 10.1016/S0140-6736(19)31795-7. Epub 2019 Aug 15. PMID: 31422895.

Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study

Yu JT, Li JQ, Suckling J, Feng L, Pan A, Wang YJ, Song B, Zhu SL, Li DH, Wang HF, Tan CC, Dong Q, Tan L, Mok V, Aisen PS, Weiner MM; Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement. 2019 Sep;15(9):1208-1217. doi: 10.1016/j.jalz.2019.05.006. Epub 2019 Aug 6.

Overview of Systematic Reviews with Meta-Analyses on Chinese Herbal Medicine in Stroke Management

HUNG CY, CHUNG VC, WU XY, HO RST, TANG EC, WU JCY, LAU AYL Adv
Integr. Med. . 2019 Sep;6(3):126-138. doi: 10.1016/j.aimed.2018.11.002

Can transcranial Doppler ultrasound be used for screening cerebral small vessel diseases in the community?

Kang D, Wong A, Fu J, Qun X, Liu W, Wang Z, Lin S, Kwan P, Lo E, Au LWC, Ko H, Lau AYL, Leung TWH, Abrigo J, Chu WCW, Mok VCT, Lam BYK.
J Neurol Sci. 2019 Aug 29;406:116439. doi: 10.1016/j.jns.2019.116439. [Epub ahead of print]

Risk estimation before progression to mild cognitive impairment and Alzheimer's disease: an AD resemblance atrophy index.

Zhao L, Luo Y, Lew D, Liu W, Au L, Mok V, Shi L; Alzheimer Disease Neuroimaging Initiative.
Aging (Albany NY). 2019 Aug 29;11(16):6217-6236. doi: 10.18632/aging.102184. Epub 2019 Aug 29.

Physical activities attenuate the negative cognitive impact from white matter hyperintensities in stroke and TIA patients with low education

Wong A, Yiu S, Lam BYK, Leung KT, Shi L, Lo E, Abrigo J, Au LW, Lau A, Mok V.
Int J Geriatr Psychiatry. 2019 Aug 13. doi: 10.1002/gps.5194. [Epub ahead of print]

Souvenaid in the management of mild cognitive impairment: an expert consensus opinion

Cummings J, Passmore P, McGuinness B, Mok V, Chen C, Engelborghs S, Woodward M, Manzano S, Garcia-Ribas G, Cappa S, Bertolucci P, Chu LW.
Alzheimers Res Ther. 2019 Aug 17;11(1):73. doi: 10.1186/s13195-019-0528-6. Review.

Teaching NeuroImages: X-linked adrenoleukodystrophy: Spinocerebellar variant

Au LWC, Chan AYY, Mok VCT.
Neurology. 2019 Aug 13;93(7):e731-e732. doi: 10.1212/WNL.0000000000007958. No abstract available. 

Autonomic Dysfunction in Neurological Disorders

XIONG L, LEUNG TWH
Aging (Albany NY). 2019 Apr 9;11(7):1903-1904. doi: 10.18632/aging.101896. . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503877/

Neutralising Antibodies to Interferon-Beta Therapy in Relapsing Multiple Sclerosis: A Pilot Study

LAU AYL, CHAN E, LAU KK, MOK V, SIU DYW, LEE R
Hong Kong Med J. 2019 Aug;25 Suppl 5(4):22-25. https://pubmed.ncbi.nlm.nih.gov/31416982/

Effects of Collateral Circulation on Haemodynamic Flow Status in Intracranial Artery Stenosis Depicted by Computational Fluid Dynamics

LEUNG TWH, FAN SY, IP HL, LAU AYL, SIU DYW, DAI EYL, WONG LKS, LIEBESKIND DS
Hong Kong Med J. 2019 Aug;25 Suppl 5(4):18-21

Autonomic Dysfunction as Measured by Ewing Battery Test to Predict Poor Outcome After Acute Ischaemic Stroke

XIONG L, TIAN G, LEUNG HW, CHEN XY, LIN WH, LEUNG TWH, SOO YO, SIU DYW, WONG LKS
Hong Kong Med J. 2019 Aug;25 Suppl 5(4):9-11.

Risk of Intracerebral Haemorrhage in Patients With Cerebral Microbleeds Taking Warfarin for Atrial Fibrillation: A Prospective Study

SOO YO, ABRIGO J, CHU W, LEUNG KT, FONG WC, LI SH, LI R, NG PW, WONG KK, WONG LKS, LEUNG TWH
Hong Kong Med J. 2019 Aug;25 Suppl 5(4):6-8.

Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase Are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

ZHU S, WEI X, YANG X, HUANG Z, CHANG Z, XIE F, YANG Q, DING C, XIANG W, YANG H, XIA Y, FENG ZP, SUN HS, YENARI MA, SHI L, MOK VC, WANG Q
Aging Dis. 2019 Aug 1;10(4):834-846. doi: 10.14336/AD.2019.0304. eCollection 2019 Aug.

Non-coding variability at the APOE locus contributes to the Alzheimer's risk

Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY.
Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.

An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial

Bornstein NM, Saver JL, Diener HC … Leung TWH … Devlin T on behalf of the ImpACT-24B investigators
Lancet. 2019 Jul 20;394(10194):219-229. doi: 10.1016/S0140-6736(19)31192-4. Epub 2019 May 24.

Comparison of Feature Selection Methods and Machine Learning Classifiers for Radiomics Analysis in Glioma Grading

SUN P, WANG D, MOK VC, SHI L
IEEE Access. Vol. 7, pp. 102010-102020, 2019, doi: 10.1109/ACCESS.2019.2928975.

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Wilson D, Ambler G, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sánchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Schrooten M, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Assayag EB, Hallevi H, Tanaka J, Hara H, Coutts SB, Hert L, Polymeris A, Seiffge DJ, Lyrer P, Algra A, Kappelle J, Al-Shahi Salman R, Jäger HR, Lip GYH, Mattle HP, Panos LD, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Kooi ME, van Dam-Nolen DHK, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra C, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, van der Lugt A, Kelly PJ, Wardlaw JM, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network.
Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23.

Effects of Mindfulness Yoga vs Stretching and Resistance Training Exercises on Anxiety and Depression for People With Parkinson Disease: A Randomized Clinical Trial

Kwok JYY, Kwan JCY, Auyeung M, Mok VCT, Lau CKY, Choi KC, Chan HYL.
JAMA Neurol. 2019 Jul 1;76(7):755-763. doi: 10.1001/jamaneurol.2019.0534.

Exploring Causal Pathways Linking Cerebral Small Vessel Diseases Burden to Poststroke Depressive Symptoms With Structural Equation Model Analysis

LIANG Y, CHEN YK, LIU YL, MOK VCT, UNGVARI GS, CHU WCW, TANG WK, KIM JS, KIM JM
J Affect Disord. 2019 Jun 15;253:218-223. doi: 10.1016/j.jad.2019.04.092. Epub 2019 Apr 22.

Is Vascular Cognitive Impairment More Common in Asia?

LAM BYK, MOK VCT
Asian J Psychiatr. 2019 Jun;43:202-204. doi: 10.1016/j.ajp.2017.03.043. Epub 2017 Apr 5.

Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker

Abrigo J, Shi L, Luo Y, Chen Q, Chu WCW, Mok VCT; Alzheimer’s Disease Neuroimaging Initiative.
Acta Radiol. 2019 Jun;60(6):769-776. doi: 10.1177/0284185118795327. Epub 2018 Sep 5.

Comparison of Multiple Sclerosis Patients With and Without Oligoclonal IgG Bands in South China

LU T, ZHAO L, SUN X, AU C, HUANG Y, YANG Y, BAO J, WU A, KERMODE AG, QIU W, LAU AY
J Clin Neurosci. . 2019 Aug;66:51-55. doi: 10.1016/j.jocn.2019.05.025. Epub 2019 May 30.

Sphenopalatine Ganglion Stimulation to Augment Cerebral Blood Flow: A Randomized, Sham-Controlled Trial

BORNSTEIN NM, SAVER JL, DIENER HC, GORELICK PB, SHUAIB A, SOLBERG Y, DEVLIN T, LEUNG T, MOLINA CA, IMPACT-24A INVESTIGATORS†; IMPACT-24A INVESTIGATORS INCLUDE THE SITE PRINCIPAL INVESTIGATORS, DSMB MEMBERS, AND THE SITE CO-INVESTIGATORS LISTED
Stroke. 2019 May 23;STROKEAHA118024582. doi: 10.1161/STROKEAHA.118.024582. Online ahead of print.

Effectiveness and Cost-Effectiveness of a Virtual Multidisciplinary Stroke Care Clinic for Community-Dwelling Stroke Survivors and Caregivers: A Randomised Controlled Trial Protocol

CHAU JPC, LO SHS, LEE VWY, CHOI KC, SHUM EWC, HUNG ZSS, MOK VCT, SIOW EKC, CHING JYL, LAM SKY, YEUNG JHM, LI SH, LAU AYL
BMJ Open. 2019 May 10;9(5):e026500. doi: 10.1136/bmjopen-2018-026500.

Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats

Xiao M, Qian C, Luo X, Yang M, Zhang Y, Wu C, Mok C, Lee P, Zuo Z
J Ethnopharmacol. 2019 May 10;235:100-110. doi: 10.1016/j.jep.2019.01.040. Epub 2019 Jan 30. PMID: 30710735.

Relapsing Optic Neuritis and Meningoencephalitis in a Child: Case Report of Delayed Diagnosis of MOG-IgG Syndrome

ZHONG X, CHANG Y, TAN S, WANG J, SUN X, WU A, PENG L, LAU AY, KERMODE AG, QIU W
BMC Neurol. 2019 May 9;19(1):94. doi: 10.1186/s12883-019-1324-4. https://pubmed.ncbi.nlm.nih.gov/31072329/

Worldwide Research Trends on Aristolochic Acids (1957-2017): Suggestions for Researchers

ZHOU Q, PEI J, POON J, LAU AY, ZHANG L, WANG Y, LIU C, HUANG L
PLoS One. 2019 May 2;14(5):e0216135. doi: 10.1371/journal.pone.0216135. eCollection 2019.

Hemodynamics and Stroke Risk in Intracranial Atherosclerotic Disease

LENG X, LAN L, IP HL, ABRIGO J, SCALZO F, LIU H, FENG X, CHAN KL, FAN FSY, MA SH, FANG H, XU Y, LI J, ZHANG B, XU Y, SOO YOY, MOK VCT, YU SCH, LIEBESKIND DS, WONG KS, LEUNG TW
Ann Neurol. 2019 May;85(5):752-764. doi: 10.1002/ana.25456. Epub 2019 Apr 3.

Seizure and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalomyelitis in a Retrospective Cohort of Chinese Patients

ZHONG X, ZHOU Y, CHANG Y, WANG J, SHU Y, SUN X, PENG L, LAU AY, KERMODE AG, QIU W
Front Neurol. 2019 Apr 26;10:415. doi: 10.3389/fneur.2019.00415. eCollection 2019.

Electromyography Activity Level in Rapid Eye Movement Sleep Predicts Neurodegenerative Diseases in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A 5-year Longitudinal Study

LIU Y, ZHANG J, LAM SP, YU MWM, LI SX, ZHOU J, CHAN NY, WANG J, FENG H, CHAN A, MOK V, WING YK
Sleep Med. 2019 Apr;56:128-134. doi: 10.1016/j.sleep.2019.01.018. Epub 2019 Jan 28.

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis

CHAN VTT, SUN Z, TANG S, CHEN LJ, WONG A, THAM CC, WONG TY, CHEN C, IKRAM MK, WHITSON HE, LAD EM, MOK VCT, CHEUNG CY
Ophthalmology. 2019 Apr;126(4):497-510. doi: 10.1016/j.ophtha.2018.08.009. Epub 2018 Aug 13.

Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis

Marini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, Flaherty ML, Montaner J, Roquer J, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tarraga C, Slowik A, Jagiella JM, Pera J, Urbanik A, Pichler A, Hansen BM, McCauley JL, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Testai FD, Kittner SJ, Schmidt H, Enzinger C, Deary IJ, Rannikmae K, Samarasekera N, Al-Shahi Salman R, Sudlow CL, Klijn CJM, van Nieuwenhuizen KM, Fernandez-Cadenas I, Delgado P, Norrving B, Lindgren A, Goldstein JN, Viswanathan A, Greenberg SM, Falcone GJ, Biffi A, Langefeld CD, Woo D, Rosand J, Anderson CD; International Stroke Genetics Consortium
JAMA Neurol. 2019 Apr 1;76(4):480-491. doi: 10.1001/jamaneurol.2018.4519. PMID: 30726504; PMCID: PMC6459133.

Risk of Intracerebral Haemorrhage in Chinese Patients With Atrial Fibrillation on Warfarin With Cerebral Microbleeds: The IPAAC-Warfarin Study

SOO Y, ABRIGO JM, LEUNG KT, TSANG SF, IP HL, MA SH, MA K, FONG WC, LI SH, LI R, NG PW, WONG KK, LIU W, LAM BYK, WONG KSL, MOK V, CHU WCW, LEUNG TW, IPAAC STUDY GROUP
J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):428-435. doi: 10.1136/jnnp-2018-319104. Epub 2018 Dec 15.

A case-control-family study of idiopathic rapid eye movement sleep behavior disorder

Liu Y, Zhang J, Lam SP, Zhou J, Yu MWM, Li SX, Chan JWY, Postuma RB, Mok VCT, Wing YK
Ann Neurol. 2019 Apr;85(4):582-592. doi: 10.1002/ana.25435. Epub 2019 Mar 19. PMID: 30761606.

Plasma and CSF miRNA dysregulations in subarachnoid hemorrhage reveal clinical courses and underlying pathways

Chan MTH, Wong JYY, Leung AKT, Lu G, Poon WS, Lau AY, Chan WY, Wong GKC
J Clin Neurosci. 2019 Apr;62:155-161. doi: 10.1016/j.jocn.2018.11.038. Epub 2018 Nov 24. PMID: 30482403.

Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis

Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem MA, DeCarli C, Ding D, Gudnason V, Hara H, Imaizumi T, Kohara K, Kwon HM, Launer LJ, Mok V, Phan T, Preis SR, Romero JR, Seshadri S, Srikanth V, Takashima Y, Tsushima Y, Wang Z, Wolf PA, Xiong Y, Yamaguchi S, Werring DJ.
Neurology. 2019 Mar 5;92(10):e1086-e1097. doi: 10.1212/WNL.0000000000007039. Epub 2019 Feb 1.

Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial

Anderson CS, Huang Y, Lindley RI … Leung WHT … Ngo Van D on behalf of the ENCHANTED Investigators and Coordinators
Lancet. 2019 Mar 2;393(10174):877-888. doi: 10.1016/S0140-6736(19)30038-8. Epub 2019 Feb 7.

Early Identification of High-Risk TIA or Minor Stroke Using Artificial Neural Network

CHAN KL, LENG X, ZHANG W, DONG W, QIU Q, YANG J, SOO Y, WONG KS, LEUNG TW, LIU J
Front Neurol. 2019 Mar 1;10:171. doi: 10.3389/fneur.2019.00171. eCollection 2019.

External Counterpulsation Enhances Neuroplasticity to Promote Stroke Recovery

LIU JY, XIONG L, STINEAR CM, LEUNG H, LEUNG TW, WONG KSL
J Neurol Neurosurg Psychiatry. 2019 Mar;90(3):361-363. doi: 10.1136/jnnp-2018-318185. Epub 2018 May 29.

Evaluation of Novel Parkinson's Disease Candidate Genes in the Chinese Population

CHEW EGY, LIANY H, TAN LCS, AU WL, PRAKASH KM, ANNUAR AA, CHAN AYY, LIM SY, MOK V, CHUNG SJ, SONG K, LIU J, FOO JN, TAN EK
Neurobiol Aging. 2019 Feb;74:235.e1-235.e4. doi: 10.1016/j.neurobiolaging.2018.09.013. Epub 2018 Sep 21.

Brain volume loss can predict cognitive impairments by neuropsychological battery in a cross-sectional study of Chinese patients with multiple sclerosis

MOK VCT, WONG A, LAU AY, ABRIGO J, SHI L
Mult. Scler. J. 2019 Feb ;25(3):442-443. doi: 10.1177/1352458519826874 .

Potential Retinal Biomarkers for Dementia: What Is New?

CHEUNG CY, CHAN VTT, MOK VC, CHEN C, WONG TY
Curr Opin Neurol. 2019 Feb;32(1):82-91. doi: 10.1097/WCO.0000000000000645.

Cortico-Muscular Coherence Modulated by High-Definition Transcranial Direct Current Stimulation in People With Chronic Stroke

Bao SC, Wong WW, Leung TW, Tong KY.
IEEE Trans Neural Syst Rehabil Eng. 2019 Feb;27(2):304-313. doi: 10.1109/TNSRE.2018.2890001. Epub 2018 Dec 27.

Brain Histopathological Study and Prognosis in MOG Antibody-Associated Demyelinating Pseudotumor

SHU Y, LONG Y, WANG S, HU W, ZHOU J, XU H, CHEN C, OU Y, LU Z, LAU AY, YU X, KERMODE AG, QIU W
Ann Clin Transl Neurol. 2019 Jan 8;6(2):392-396. doi: 10.1002/acn3.712. eCollection 2019 Feb.

Vascular dysfunction-The disregarded partner of Alzheimer's disease

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Al-Shahi Salman R, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV
Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222. Erratum in: Alzheimers Dement. 2022 Mar;18(3):522. PMID: 30642436; PMCID: PMC6338083.

Early-onset dementia in Chinese: Demographic and etiologic characteristics

AU LWC, WONG A, ABRIGO J, YUEN YP, LEUNG EYL, MOK VCT
Neurol Asia. 2019;24(2):139-146.

Frequency-specific Age-Related Decreased Brain Network Diversity in Cognitively Healthy Elderly: A Whole-Brain Data-Driven Analysis

LOU W, WANG D, WONG A, CHU WCW, MOK VCT, SHI L
Hum Brain Mapp. 2019 Jan;40(1):340-351. doi: 10.1002/hbm.24376. Epub 2018 Sep 21.

A Pharmacokinetic Approach To Herb-Drug Interaction Between Gastrodiae Rhizoma And Carbamazepine In A Model Of Rats

Yip, KL; Koon, CM; Chen, Z; Chook, P; Leung, PC; Schachter, S; Leung, WH; Mok, CT; Leung, H
EPILEPSIA. Year: 2019 Volume: 60 Supplement: 2 Meeting Abstract: P86 Pages: 48-48; Times Cited: 0; IF 6.040, Ranking 20/204.

A Prospective, Longitudinal Study Of Ampa-Antagonist In Chinese Patients With Refractory Epilepsy

Leung, H; Yuen, SL; Ma, K; Ip, B; Ma, SH; Leung, T; Yip, KL; Mok, V
EPILEPSIA. Year: 2019 Volume: 60 Supplement: 2 Meeting Abstract: P267 Pages: 127-128; Times Cited: 0; IF 6.040, Ranking 20/204.

TPK1 mutation induced childhood onset dystonia and dyskinesia

Au, L; Chan, A; Lau, C; Mok, V
MOVEMENT DISORDERS, Year: 2019 Volume: 34 Supplement: 2 Special Issue: SI Meeting Abstract: 412 Pages: S166-S166; Times Cited: 0; IF 8.679, Ranking 11/204. https://www.mdsabstracts.org/abstract/tpk1-mutation-induced-childhood-onset-dystonia-and-dyskinesia/

Bilateral Globus pallidus interna Deep Brain Stimulation in Cranio-Cervical Dystonia (Meige syndrome) patient in Hong Kong

Lau, C; Zhu, C; Chan, D; Ma, K; Au, L; Chan, A; Wong, R; Yeung, J; Poon, W; Mok, V
MOVEMENT DISORDERS. Year: 2019 Volume: 34 Supplement: 2 Special Issue: SI Meeting Abstract: 1302 Pages: S533-S533; Times Cited: 0; IF 8.679, Ranking 11/204

Neurocognitive changes after STN-DBS among PD patients - a 2-year follow-up study in Hong Kong

Tang, V; Chan, D; Zhu, XL; Chan, D; Lau, C; Chan, A; Ma, K; Yeung, J; Mok, V; Poon, W
MOVEMENT DISORDERS. Year: 2019 Volume: 34 Supplement: 2 Special Issue: SI Meeting Abstract: 1737 Pages: 713-714; Times Cited: 0; IF 8.679, Ranking 11/204.

2018

Risk factors associated with 31-day unplanned readmission in 50,912 discharged patients after stroke in China

Wen T, Liu B, Wan X, Zhang X, Zhang J, Zhou X, Lau AYL, Zhang Y
BMC Neurol. 2018 Dec 26;18(1):218. doi: 10.1186/s12883-018-1209-y. PMID: 30587162; PMCID: PMC6306006.. https://pubmed.ncbi.nlm.nih.gov/30587162/

Morphological diversity, protein adsorption, and cellular uptake of polydopamine-coated gold nanoparticles

Sy SKH, Ho LWC, Lau WCY, Ko H, Choi CHJ
Langmuir. 2018 Nov 20;34(46):14033-14045.

Retinal image analytics detects white matter hyperintensities in healthy adults

Lau AY, Mok V, Lee J, Fan Y, Zeng J, Lam B, Wong A, Kwok C, Lai M, Zee B
Ann Clin Transl Neurol. 2018 Nov 15;6(1):98-105. doi: 10.1002/acn3.688. PMID: 30656187; PMCID: PMC6331948.

Oncogenes expand during evolution to withstand somatic amplification

Wang X, Li X, Zhang L, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK
Ann Oncol. 2018 Nov 1;29(11):2254-2260. doi: 10.1093/annonc/mdy397. PMID: 30204835.

Microvascular resistance and collateral circulation in simulating the stenotic coronary arteries

Liu H, Leung TWH, Shi L
J Appl Physiol (1985). 2018 Oct 1;125(4):1352. doi: 10.1152/japplphysiol.00283.2018. PMID: 30354945.

Comparison of Computerized and Paper-and-Pencil Memory Tests in Detection of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies

Chan JYC, Kwong JSW, Wong A, Kwok TCY, Tsoi KKF.
J Am Med Dir Assoc. 2018 Sep;19(9):748-756.e5. doi: 10.1016/j.jamda.2018.05.010. Epub 2018 Jun 18.

Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment

Shi L, Zhao L, Yeung FK, Wong SY, Chan RKT, Tse MF, Chan SC, Kwong YC, Li KC, Liu K, Abrigo JM, Lau AYL, Wong A, Lam BYK, Leung TWH, Fu J, Chu WCW, Mok VCT
J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):918-926. doi: 10.1136/jnnp-2017-317817. Epub 2018 Apr 17. PMID: 29666204.

Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study

Zheng L, Yang WJ, Niu CB, Zhao HL, Wong KS, Leung TWH, Chen XY
J Stroke. 2018 Sep;20(3):342-349. doi: 10.5853/jos.2018.01263. Epub 2018 Sep 30. PMID: 30309229; PMCID: PMC6186920.

High-resolution magnetic resonance vessel wall imaging of chronic intracranial internal carotid artery occlusion

Chen X, Yang W, Chu CW, Wong KS, Leung TWH
J Neuroradiol. 2018 Sep;45(5):336-337. doi: 10.1016/j.neurad.2018.04.005. Epub 2018 May 9. PMID: 29752977.

Strategic infarct location for post-stroke cognitive impairment: A multivariate lesion-symptom mapping study

Zhao L, Biesbroek JM, Shi L, Liu W1, Kuijf HJ, Chu WW, Abrigo JM, Lee RK, Leung TW, Lau AY, Biessels GJ, Mok V, Wong A.
J Cereb Blood Flow Metab. 2018 Aug;38(8):1299-1311. doi: 10.1177/0271678X17728162. Epub 2017 Sep 12.

Correlation of non-vitamin K antagonist oral anticoagulant exposure and cerebral microbleeds in Chinese patients with atrial fibrillation

Soo Y, Abrigo J, Leung KT, Liu W, Lam B, Tsang SF, Ip V, Ma K, Ip B, Ma SH, Fan F, Chu W, Wong L, Mok V, Leung TW.
J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):680-686. doi: 10.1136/jnnp-2017-317151. Epub 2018 Mar 29.

Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia

Wong OW, Chan AY, Wong A, Lau CK, Yeung JH, Mok VC, Lam LC, Chan S.
Parkinsonism Relat Disord. 2018 Jul;52:43-48. doi: 10.1016/j.parkreldis.2018.03.013. Epub 2018 Mar 15.

Marriage and risk of dementia: systematic review and meta-analysis of observational studies

Chen PLH, Mok Vincent VCT.
J NEUROL NEUROSURG PSYCHIATRY. 2018 JUL;89(3):231-238. doi: 10.1136/jnnp-2017-316274.

High prevalence and indexes of anti-John Cunningham virus antibodies in a cohort of Chinese patients with multiple sclerosis.

Lau AYL, Qiu W, Kermode A, Au C, Ng A, Wong A, Ma SH, Au L, Ma K, Ip B, Mok VCT.
Mult Scler J Exp Transl Clin. 2018 Jul-Sep; 4(3): 2055217318788699.

Low Gamma Band Cortico-muscular Coherence Inter-Hemisphere Difference following Chronic Stroke

Bao SC, Wong WW, Leung TW, Tong KY
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:247-250. doi: 10.1109/EMBC.2018.8512208. PMID: 30440384.

The era after DAWN: treatment of acute ischaemic stroke.

Lau KK, Thomas WH Leung TWH, Soo YOY.
Hong Kong Med J . 2018 Jun;24(3):313–5.

Validity and reliability of two alternate versions of the Montreal Cognitive Assessment (Hong Kong version) for screening of Mild Neurocognitive Disorder

Wong A, Yiu S, Nasreddine Z, Leung KT, Lau A, Soo YOY, Wong LKS, Mok VCT.
PLoS ONE. 2018 May;13(5): e0196344

The Additional Contribution of White Matter Hyperintensity Location to Post-stroke Cognitive Impairment: Insights From a Multiple-Lesion Symptom Mapping Study

Zhao L, Wong A, Luo Y, Liu W, Chu WWC, Abrigo JM, Lee RKL, Mok V, Shi L.
Front Neurosci. 2018 May 1;12:290. doi: 10.3389/fnins.2018.00290. eCollection 2018.

Impact of intracranial artery calcification on cerebral hemodynamic changes.

Wu X, Wang L, Zhong J, Ko J, Shi L, Soo Y, Leung T, Wong KS, Abrigo J, Chen X.
Neuroradiology. 2018 Apr;60(4):357-363. doi: 10.1007/s00234-018-1988-2. Epub 2018 Feb 9.

Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori

Zhang L, Hu W, Cho CH, Chan FK, Yu J, Fitzgerald JR, Cheung CK, Xiao ZG, Shen J, Li LF, Li MX, Wu JC, Ling TK, Chan JY, Ko H, Tse G, Ng SC, Yu S, Wang MH, Gin T, Ashktorab H, Smoot DT, Wong SH, Chan MT, Wu WK
J Pathol. 2018 Apr;244(4):432-444. doi: 10.1002/path.5033. Epub 2018 Feb 28. PMID: 29327342.

Automatic Segmentation of Acute Ischemic Stroke From DWI Using 3-D Fully Convolutional DenseNets

Zhang RZ, Zhao L, Lou WT, Abrigo JM, Mok VCT, Chu WCW, Wang DF, Lin S.
IEEE Transactions on Medical Imaging. 2018 Mar:37(9):2149-2160.

Association Between the Apolipoprotein E Gene Polymorphism and Atherosclerotic Middle Cerebral Artery Stenosis.

Zhang Z, Chen XY, Baum L, Ng HK, Mok V, Wong KS.
Neurologist. 2018 Mar;23(2):47-50. doi: 10.1097/NRL.0000000000000164.

Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack

Wong A, Black SE, Yiu SYP, Au LWC, Lau AYL, Soo YOY, Chan AYY, Leung TWH1, Wong LKS, Kwok TCY, Cheung TCK, Leung KT, Lam BYK, Kwan JSK, Mok VCT.
Int J Geriatr Psychiatry. 2018 May;33(5):729-734. doi: 10.1002/gps.4846. Epub 2018 Jan 2.

Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study.

Liang Y, Chan YL, Deng M, Chen YK, Mok V, Wang F, Ungvari GS, Chu CW, Tang WK.
J Affect Disord. 2018 Mar 1;228:166-172. doi: 10.1016/j.jad.2017.11.080. Epub 2017 Nov 22.

Cerebral Small Vessel Disease Burden Is Associated With Poststroke Depressive Symptoms: A 15-Month Prospective Study

Liang Y, Chen YK, Mok VCT, Wang DF, Ungvari GS, Chu WCW, Kang HJ, Tang WK.
Front Aging Neurosci. 2018;10:46.

Vascular cognitive impairment

Flier WM, Skoog I, Julie A. Schneider JA, Pantoni L, Mok VCT, Chen CLH, Scheltens P.
Nat Rev Dis Primers. 2018 Feb; 18003.

Antiplatelet therapy after stroke: should it differ in the acute and chronic phase after stroke

Leng X, Leung TW, Wong KSL.
Curr Opin Neurol. 2018 Feb;31(1):14-22. doi: 10.1097/WCO.0000000000000509.

Long-Term Evolutionary Change in the Lumen of Intracranial Atherosclerotic Stenosis Following Angioplasty and Stenting

Yu SCH, Lau TWW, Wong SSM, Lee KT, Wong LKS, Leung TWH.
Oper Neurosurg (Hagerstown). 2018 Feb 1;14(2):128-138. doi: 10.1093/ons/opx097.

Translesional pressure gradient and leptomeningeal collateral status in symptomatic middle cerebral artery stenosis.

Leng X, Lan L, Ip HL, Fan F, Ma SH, Ma K, Liu H, Yan Z, Liu J, Abrigo J, Soo YOY, Liebeskind DS, Wong KS, Leung TW.
Eur J Neurol. 2018 Feb;25(2):404-410. doi: 10.1111/ene.13521. Epub 2017 Dec 18.

Effects of Acupuncture on the Recovery Outcomes of Stroke Survivors with Shoulder Pain: A Systematic Review.

Chau JPC, Lo SHS, Yu X, Choi KC, Lau AYL, Wu JCY, Lee VWY, Cheung WHN, Ching JYL, Thompson DR.
Front Neurol. 2018 Jan 31;9:30. doi: 10.3389/fneur.2018.00030. eCollection 2018.

White Matter Hyperintensity Predicts the Risk of Incident Cognitive Decline in Community Dwelling Elderly

Ding D, Xiong Y, Zhao Q, Guo Q, Chu S, Chu WWC, Luo J, Liang X, Zheng L, Hong Z, Wong LKS, Mok VCT.
J Alzheimers Dis. 2018;61(4):1333-1341. doi: 10.3233/JAD-170876.

Morphological Evolution or Symptomatic Irltracranial A herosclerotic Plaques: a 10-year Longitudinal Study by 3-Dimensional Rotational Angiography

Leng XY, Wang L, Zou XY, Soo YOY, Chan AYY, Ip VHL, Fan FSY, Mok CT, Wong LKS, Yu SCH, Leung TWH.
Stroke. 2018;49:A86.

Morphology of Acute Symptomatic Intracranial Atherosclerotic Plaques

Leng XY, Wang L, Zou XY, Soo YOY, Chan AYY, Ip VHL, Fan FSY, Mok CT, Wong LKS, Yu SCH, Leung TWH.
Stroke. 2018;49:ATP127.

Postmortem Study Exploring Distribution and Patterns of Intracranial Arterial Calcification.

Yang WJ, Zheng L, Wu XH, Niu CB, W Leung TW, Chen XY.
Stroke. 2018;49:AWMP44.

Use of Acupuncture to Reduce Hemiplegic Shoulder Pain is Feasible and Acceptable among Community-Dwelling Stroke Survivors.

Chau JPC, Lo SHS, Lau AYL, Wu JCY, Cheung WHN, Ching JYL, Choi KC, Lee VWY, Sit JWH, Thompson DR.
Stroke. 2018;49:ATP152.

Estimating current and long-term risks of coronary artery in silico by fractional flow reserve, wall shear stress and low-density lipoprotein filtration rate

Haipeng Liu1,2,5, Yinglan Gong3,5, Xinyi Leng1, Ling Xia3, Ka Sing Wong1, Shanxing Ou4, Thomas W Leung1,6, Defeng Wang2 and Lin Shi2,6
Biomedical Physics & Engineering Express. 2018 Jan;4(2).

Preliminary Results of An Observational Study to Evaluate Integrative Medicine in Managing Fatigue and Cognitive Deficits Associated with Multiple Sclerosis

Ng A, Lam M, Au C, Yuen D, Cheung W, Hung Z, Lin WL, Chung V, Wong A, Chan J, Poon S, Poon J, Mok V, Wu J, Lau A.
Mult Scler J. 2018; 402-403.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O7, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM5, Mattsson N7, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ5, Aalten P1, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ; Amyloid Biomarker Study Group, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BNM3, Blennow K, van Buchem MA, Cavedo E, Chen K, Chipi E, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gkatzima O, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Johannsen P, Klimkowicz-Mrowiec A, Köhler S, Koglin N, van Laere K, de Leon M, Lisetti V, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Nordlund A, Novak GP, Paraskevas GP, Perera G, Peters O, Ramakers IHGB, Rami L, Rodríguez-Rodríguez E, Roe CM, Rot U, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE8, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Zetterberg H.
JAMA Psychiatry. 2018 Jan 1;75(1):84-95. doi: 10.1001/jamapsychiatry.2017.3391.

Autonomic Dysfunction Predicts Clinical Outcomes After Acute Ischemic Stroke: A Prospective Observational Study.

Xiong L, Tian G, Leung H, Soo YOY, Chen X, Ip VHL, Mok VCT, Chu WCW, Wong KS, Leung TWH.
Stroke. 2018 Jan;49(1):215-218. doi: 10.1161/STROKEAHA.117.019312. Epub 2017 Dec 4.

Impact of Side Branches on the Computation of Fractional Flow in Intracranial Arterial Stenosis Using the Computational Fluid Dynamics Method.

Liu H, Lan L, Leng X, Ip HL, Leung TWH, Wang D, Wong KS.
J Stroke Cerebrovasc Dis. 2018 Jan;27(1):44-52. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.032. Epub 2017 Oct 27.

Impact of Side Branches on the Computation of Fractional Flow in Intracranial Arterial Stenosis Using the Computational Fluid Dynamics Method

Liu H, Lan L, Leng X, Ip HL, Leung TWH, Wang D, Wong KS
J Stroke Cerebrovasc Dis. 2018 Jan;27(1):44-52. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.032. Epub 2017 Oct 27. PMID: 29107636.

2017

The Association Between Diabetes and Olfactory Function in Adults

Chan JYK, García-Esquinas E, Ko OH, Tong MCF, Lin SY
Chem Senses. 2017 Dec 25;43(1):59-64. doi: 10.1093/chemse/bjx070. PMID: 29126164.

Cerebral perfusion difference between hemispheres with symptomatic and asymptomatic intracranial arterial stenosis.

Lan L, Leng X, Abrigo J, Ip V, Soo YO, Leung T, Chen X, Wong KS.
Int J Stroke. 2017 Dec;12(9):NP19-NP20. doi: 10.1177/1747493016676284. Epub 2016 Oct 20.

Brain microbleeds, anticoagulation, and hemorrhage risk: Meta-analysis in stroke patients with AF

Charidimou A, Karayiannis C, Song TJ, Orken DN, Thijs V, Lemmens R, Kim J, Goh SM, Phan TG, Soufan C, Chandra RV, Slater LA, Haji S, Mok V, Horstmann S, Leung KT, Kawamura Y, Sato N, Hasebe N, Saito T, Wong LKS, Soo Y, Veltkamp R, Flemming KD, Imaizumi T, Srikanth V, Heo JH
Neurology. 2017 Dec 5;89(23):2317-2326. doi: 10.1212/WNL.0000000000004704.

Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke

Liang Y, Deng M, Chen YK, Mok V, Wang DF, Ungvari GS, Chu CW, Berge E, Tang WK
CNS Neurosci Ther. 2017 Dec;23(12):973-979. doi: 10.1111/cns.12766.

Minimum Clinically Important Difference of Montreal Cognitive Assessment in aneurysmal subarachnoid hemorrhage patients.

Wong GKC, Mak JSY, Wong A, Zheng VZY, Poon WS, Abrigo J, Mok VCT.
J Clin Neurosci. 2017 Dec;46:41-44. doi: 10.1016/j.jocn.2017.08.039. Epub 2017 Sep 5.

Early versus Late Application of Subthalamic deep brain Stimulation to Parkinson's disease patients with motor complications (ELASS): protocol of a multicentre, prospective and observational study

Jiang L, Poon WS, Moro E, Xian W, Yang C, Zhu XL, Gu J, Cai X, Liu J, Mok V, Liu Y, Xu S, Guo Q, Chen W, Chen L
BMJ Open. 2017 Nov 16;7(11):e018610. doi: 10.1136/bmjopen-2017-018610.

The Spatial Associations of Cerebral Blood Flow and Spontaneous Brain Activities with White Matter Hyperintensities-An Exploratory Study Using Multimodal Magnetic Resonance Imaging.

Shi L, Miao X, Lou W, Liu K, Abrigo J, Wong A, Chu WCW, Wang D, Mok VCT.
Front Neurol. 2017 Nov 9;8:593. doi: 10.3389/fneur.2017.00593. eCollection 2017.

Using Retinal Imaging to Study Dementia

Chan VTT, Tso THK, Tang F, Tham C, Mok V, Chen C, Wong TY, Cheung CY
J Vis Exp. 2017 Nov 6;(129). doi: 10.3791/56137.

Association of Cerebral Small Vessel Disease Burden and Health-Related Quality of Life after Acute Ischemic Stroke.

Liang Y, Chen YK, Deng M, Mok VCT, Wang DF, Ungvari GS, Chu CW, Kamiya A, Tang WK.
Front Aging Neurosci. . 2017 Nov 13;9:372. doi: 10.3389/fnagi.2017.00372. eCollection 2017.

Current status of home blood pressure monitoring in Asia: Statement from the HOPE Asia Network

Chia YC1, Buranakitjaroen P, Chen CH, Divinagracia R, Hoshide S, Park S, Shin J, Siddique S, Sison J, Soenarta AA, Sogunuru GP, Tay JC, Turana Y, Wang JG, Wong L, Zhang Y, Kario K; HOPE Asia Network
J Clin Hypertens (Greenwich). 2017 Nov;19(11):1192-1201. doi: 10.1111/jch.13058. Epub 2017 Aug 17.

Cognitive profiles in Hong Kong Chinese with relapsing and progressive multiple sclerosis.

Lau AY, Ng A, Au C, Yuen KY, Mok V, Wu JC, Wong A.
MULT SCLER J. 2017 Oct; 23:764.

A retrospective, cross sectional controlled study of Chinese medicine for post-stroke rehabilitation.

Ma CH, Li LSW, Kwok LP, Tsang KWY, Cheng MCK, Mok VCT, Or KKH, Zhang ZJ.
J Neurol Sci. 2017 OCT 15;381:923.

Prevalence of neutralising antibodies to interferon-beta and clinical response in Chinese patients with relapsing multiple sclerosis.

Lau AY, Ip WK, Au C, Lau KK, Wong W, Yip KK, Yeung J, Li SH, Li P, Lee R, Siu D, Abrigo J, Wong A, Mok V, Chan E.
Mult Scler J Exp Transl Clin. 2017 Oct 9;3(4):2055217317733485. doi: 10.1177/2055217317733485. eCollection 2017 Oct-Dec.

Noninvasive fractional flow in intracranial atherosclerotic stenosis: Reproducibility, limitations, and perspectives.

Leng X, Lan L, Ip VHL, Liu H, Abrigo J, Liebeskind DS, Wong LKS, Leung TW.
J Neurol Sci. 2017 Oct 15;381:150-152. doi: 10.1016/j.jns.2017.08.3239. Epub 2017 Aug 24.

Smartphone electrographic monitoring for atrial fibrillation in acute ischemic stroke and transient ischemic attack

Tu HT, Chen Z, Swift C, Churilov L, Guo R, Liu X, Jannes J, Mok V, Freedman B, Davis SM, Yan B.
Int J Stroke. 2017 Oct;12(7):786-789. doi: 10.1177/1747493017696097. Epub 2017 Mar 8.

Acute basilar artery occlusion: Endovascular Interventions versus Standard Medical Treatment (BEST) Trial-Design and protocol for a randomized, controlled, multicenter study

Liu X, Xu G, Liu Y, Zhu W, Ma M, Xiong Y, Zi W, Dai Q, Leung T, Yan B, Davis S, Liebeskind DS, Pereira VM, Nogueira RG; BEST Trial Investigators
Int J Stroke. 2017 Oct;12(7):779-785. doi: 10.1177/1747493017701153. Epub 2017 Mar 31. PMID: 28361616.

Development and validation of a risk score (CHANGE) for cognitive impairment after ischemic stroke

Chander RJ, Lam BYK, Lin X, Ng AYT, Wong APL, Mok VCT, Kandiah N
Sci Rep. 2017 Sep 29;7(1):12441. doi: 10.1038/s41598-017-12755-z.

Histological Characteristics of Intracranial Atherosclerosis in a Chinese Population: A Postmortem Study.

Yang WJ, Fisher M, Zheng L, Niu CB, Paganini-Hill A, Zhao HL, Xu Y, Wong KS, NG HK, Chen XY.
Front Neurol. 2017;8:488.

Age-specific trends of atrial fibrillation-related ischaemic stroke and transient ischaemic attack, anticoagulant use and risk factor profile in Chinese population: a 15-year study

Soo Y, Chan N, Leung KT, Chen XY, Mok V, Wong L, Leung T
J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):744-748. doi: 10.1136/jnnp-2017-315735.

Recall Tests Are Effective to Detect Mild Cognitive Impairment: A Systematic Review and Meta-analysis of 108 Diagnostic Studies.

Tsoi KKF, Chan JYC, Hirai HW, Wong A, Mok VCT, Lam LCW, Kwok TCY, Wong SYS.
J Am Med Dir Assoc. 2017 Sep 1;18(9):807.e17-807.e29. doi: 10.1016/j.jamda.2017.05.016. Epub 2017 Jul 25.

Intracranial Atherosclerosis: From Microscopy to High-Resolution Magnetic Resonance Imaging.

Yang WJ, Wong KS, Chen XY.
J Stroke. 2017 Sep;19(3):249-260. doi: 10.5853/jos.2016.01956. Epub 2017 Sep 6.

Computerized Cognitive Screen (CoCoSc): A Self-Administered Computerized Test for Screening for Cognitive Impairment in Community Social Centers

Wong A, Fong CH, Mok VC, Leung KT, Tong RK
J Alzheimers Dis. 2017;59(4):1299-1306. doi: 10.3233/JAD-170196.

Using Large-Scale Statistical Chinese Brain Template (Chinese2020) in Popular Neuroimage Analysis Toolkits

Shi L, Liang PP, Luo Y, Liu K, Mok VCT, Chu WCW, Wang DF, Li KC.
Frontiers in Human Neuroscience. 2017;11:6.

Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries

Hilal S1, Mok V, Youn YC, Wong A, Ikram MK5, Chen CL
J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):669-674. doi: 10.1136/jnnp-2016-315324. Epub 2017 Jun 9.

Cortical Microinfarcts in Patients with Middle Cerebral Artery Stenosis.

Leng X, Fang H, Pu Y, Zou X, Pan Y, Soo YOY, Xu Y, Wang C, Zhao X, Wang Y, Wang Y, Liebeskind DS, Wong LKS, Leung TW6, Liu L.
J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1760-1765. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.002. Epub 2017 May 15.

External Counterpulsation Increases Beat-to-Beat Heart Rate Variability in Patients with Ischemic Stroke.

Xiong L1, Tian G, Wang L, Lin W, Chen X, Leung TWH, Soo YOY, Wong LKS.
J Stroke Cerebrovasc Dis. 2017 Jul;26(7):1487-1492. doi: 10.1016/j.jstrokecerebrovasdis.2017.03.007. Epub 2017 Apr 7.

Prediction of Recurrent Stroke or Transient Ischemic Attack After Noncardiogenic Posterior Circulation Ischemic Stroke.

Zhang C, Wang Y, Zhao X, Liu L, Wang C, Pu Y, Zou X, Pan Y, Wong KS, Wang Y; Chinese IntraCranial AtheroSclerosis (CICAS) Study Group.
Stroke. 2017 Jul;48(7):1835-1841. doi: 10.1161/STROKEAHA.116.016285. Epub 2017 Jun 16.

Refinement of learned skilled movement representation in motor cortex deep output layer

Li Q, Ko H, Qian ZM, Yan LYC, Chan DCW, Arbuthnott G, Ke Y, Yung WH
Nature communications. 2017 Jun 9;8:15834. doi: 10.1038/ncomms15834. PMID: 28598433; PMCID: PMC5472789.

Differences in Characteristics and Outcomes Between Asian and Non-Asian Patients in the TIAregistry.org

Hoshino T, Uchiyama S, Wong LKS, Sissani L, Albers GW, Bornstein NM, Caplan LR, Donnan GA, Ferro JM, Hennerici MG, Labreuche J, Lavallée PC, Molina C, Rothwell PM, Steg PG, Touboul PJ, Vicaut É, Amarenco P; TIAregistry.org Investigators.
Stroke. 2017 Jul;48(7):1779-1787. doi: 10.1161/STROKEAHA.117.016874. Epub 2017 Jun 5.

Impaired cerebral autoregulation: measurement and application to stroke.

Xiong L, Liu X, Shang T, Smielewski P, Donnelly J, Guo ZN, Yang Y, Leung T, Czosnyka M, Zhang R, Liu J, Wong KS.
J Neurol Neurosurg Psychiatry. 2017 Jun;88(6):520-531. doi: 10.1136/jnnp-2016-314385.

A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson's Disease

Ka-Kit Chua, Adrian Wong, Kam-Wa Chan, Yin-Kei Lau, Zhao-Xiang Bian, Jia-Hong Lu, Liang-Feng Liu, Lei-Lei Chen, Ka-Ho Chan, Kim-Pong Tse,1 Anne Chan, Ju-Xian Song, Justin Wu, Li-Xing Zhu, Vincent Mok, and Min Li1
Parkinsons Dis. 2017;2017:1902708.

Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder

Zhou J, Zhang J, Lam SP, Chan JW, Mok V, Chan A, Li SX4, Liu Y, Tang X, Yung WH, Wing YK
Sleep. 2017 May 1;40(5). doi: 10.1093/sleep/zsx041.

Is Dynamic Cerebral Autoregulation Bilaterally Impaired after Unilateral Acute Ischemic Stroke?

Xiong L, Tian G, Lin W, Wang W, Wang L, Leung T, Mok V, Liu J, Chen X, Wong KS
J Stroke Cerebrovasc Dis. 2017 May;26(5):1081-1087. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.024.

Intracerebral hemorrhage location and outcome among INTERACT2 participants

Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X, Hackett ML, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Robinson T, Davies L, Lavados PM, Lindley RI, Stapf C, Chalmers J, Anderson CS; INTERACT2 Investigators
Neurology. 2017 Apr 11;88(15):1408-1414. doi: 10.1212/WNL.0000000000003771. Epub 2017 Feb 24. PMID: 28235817; PMCID: PMC5386433.

Location of Acute Infarcts and Agitation and Aggression in Stroke

Tang WK, Liu XX, Liang H, Chen YK, Chu WCW, Ahuja AT, Abrigo J, Mok VCT, Ungvari GS, Wong KS, Spalletta G
J Neuropsychiatry Clin Neurosci. 2017 Spring;29(2):172-178. doi: 10.1176/appi.neuropsych.15110400.

Neuroticism and Fatigue 3 Months After Ischemic Stroke: A Cross-Sectional Study.

Lau CG, Tang WK, Liu XX, Liang HJ, Liang Y, Mok V, Wong A, Ungvari GS, Kutlubaev MA, Wong KS.
Arch Phys Med Rehabil. 2017 Apr;98(4):716-721. doi: 10.1016/j.apmr.2016.08.480. Epub 2016 Sep 24.

Intracranial atherosclerosis: From anatomy to pathophysiology.

Pu Y, Lan L, Leng X, Wong LK, Liu L.
Int J Stroke. 2017 Apr;12(3):236-245. doi: 10.1177/1747493016685716. Epub 2017 Jan 9.

Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms

Mok VC, Lam BY, Wong A, Ko H, Markus HS, Wong LK
Nat Rev Neurol. 2017 Mar;13(3):148-159. doi: 10.1038/nrneurol.2017.16.

Symptomatic Patients Remain at Substantial Risk of Arterial Disease Complications Before and After Endarterectomy or Stenting.

Hobeanu C, Lavallée PC, Rothwell PM, Sissani L, Albers GW, Bornstein NM, Caplan LR, Donnan GA, Ferro JM, Hennerici MG, Labreuche J, Molina C, Steg PG, Touboul PJ, Uchiyama S, Vicaut É, Wong LK, Amarenco P; TIAregistry.org Investigators.
Stroke. 2017 Apr;48(4):1005-1010. doi: 10.1161/STROKEAHA.116.015171. Epub 2017 Mar 13.

Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects.

Liu K, Zhang T, Chu WC, Mok VC, Wang D, Shi L
Neuroscience. 2017 Mar 6;344:15-24. doi: 10.1016/j.neuroscience.2016.12.026.

Poststroke agitation and aggression and social quality of life: a case control study.

Lau CG, Tang WK, Liu XX, Liang HJ, Liang Y, Wong A, Mok V, Ungvari GS, Wong KS, Kim JS, Paradiso S.
Top Stroke Rehabil. 2017 Mar;24(2):126-133. doi: 10.1080/10749357.2016.1212564. Epub 2016 Sep 7.

Clinical Features of Thalamic Stroke

Chen XY, Wang Q, Wang X, Wong KS
Curr Treat Options Neurol . 2017 Feb;19(2):5. doi: 10.1007/s11940-017-0441-x.

Limb girdle myasthenia with digenic RAPSN and a novel disease gene AK9 mutations

Lam CW, Wong KS, Leung HW, Law CY.
Eur J Hum Genet. 2017 Feb;25(2):192-199. doi: 10.1038/ejhg.2016.162. Epub 2016 Dec 14.

High Extent of Intracranial Carotid Artery Calcification Is Associated with Downstream Microemboli in Stroke Patients.

Wu XH, Chen XY, Fan YH, Leung TW, Wong KS.
J Stroke Cerebrovasc Dis. 2017 Feb;26(2):442-447. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.007. Epub 2016 Nov 3.

Cross-Cultural Differences of the Non-Motor Symptoms Studied by the Traditional Chinese Version of the International Parkinson and Movement Disorder Society- Unified Parkinson's Disease Rating Scale

Yu RL1, Wu RM, Chan AY, Mok V, Wu YR, Tilley BC, Luo S, Wang L, LaPelle NR, Stebbins GT, Goetz CG
Mov Disord Clin Pract. 2017 Jan-Feb;4(1):68-77. doi: 10.1002/mdc3.12349.

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Wang L, Heckman MG, Aasly JO, Annesi G, Bozi M, Chung SJ, Clarke C, Crosiers D, Eckstein G, Garraux G, Hadjigeorgiou GM, Hattori N, Jeon B, Kim YJ, Kubo M, Lesage S, Lin JJ, Lynch T, Lichtner P, Mellick GD, Mok V, Morrison KE, Quattrone A, Satake W, Silburn PA, Stefanis L, Stockton JD, Tan EK, Toda T, Brice A, Van Broeckhoven C, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM, Gasser T, Krüger R, Farrer MJ, Ross OA, Sharma M
Neurobiol Aging. 2017 Jan;49:217.e1-217.e4. doi: 10.1016/j.neurobiolaging.2016.09.022.

Genome-wide association study of Parkinson's disease in East Asians

Foo JN, Tan LC, Irwan ID, Au WL, Low HQ, Prakash KM, Ahmad-Annuar A, Bei J, Chan AY, Chen CM, Chen YC, Chung SJ, Deng H, Lim SY, Mok V, Pang H, Pei Z, Peng R, Shang HF, Song K, Tan AH, Wu YR, Aung T, Cheng CY, Chew FT, Chew SH, Chong SA, Ebstein RP, Lee J, Saw SM, Seow A, Subramaniam M, Tai ES, Vithana EN, Wong TY, Heng KK, Meah WY, Khor CC, Liu H, Zhang F, Liu J, Tan EK
Hum Mol Genet. 2017 Jan 1;26(1):226-232. doi: 10.1093/hmg/ddw379.

Deep Cascaded Networks for Sparsely Distributed Object Detection from Medical Images

Chen, H Dou, Q Yu, L Qin, J Zhao, L Mok, VCT Wang, D Shi, L Heng, PA
Deep Learning for Medical Image Analysis. 2017:(6):133-135.

A 5-Year Longitudinal Study of Cognitive Decline After Stroke/Transient Ischemic Attack (CU-STRIDE).

Lam B, Wong A, Wang ZL, Liu WY, Au L, Chan A, Lau A, Shi L, Fan F, Ma SH, Ip V, Soo Y, Leung T, Leng XY, Chen XY, Chu W, Mok V.
Cerebrovasc Dis. 2017;44(S1):4.

Prolonged Perfusion Predicts Recurrent Ischemic Stroke but not Transient Ischemic Attack in Patients with Symptomatic Intracranial Stenosis.

Lan L, Leng X, Ip V, Leung T, Soo Y, Abrigo J, Wong KS.
Curr Neurovasc Res. 2017;14(2):149-157. doi: 10.2174/1567202614666170413143203.

The prognosis of acute symptomatic seizures after ischaemic stroke.

Leung T, Leung H, Soo YO, Mok VC, Wong KS.
J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):86-94. doi: 10.1136/jnnp-2015-311849. Epub 2016 Jan 27.

Benign Oligemia in Subacute Stage Is Associated with Borderzone Infarction in Stroke Patients Caused by Intracranial Large Artery Disease

Li J, Chen XY, Soo Y, Leung TW, Zeng J, Wong KS.
Eur Neurol. 2017;77(1-2):80-86. doi: 10.1159/000454678. Epub 2016 Dec 14.

Morphometry analysis of basal ganglia structures in children with obstructive sleep apnea.

Lv J, Shi L, Zhao L, Weng J, Mok VC, Chu WC, Wang D.
J Xray Sci Technol. 2017;25(1):93-99. doi: 10.3233/XST-16171.

Sex Differences Do Not Exist in Outcomes among Stroke Patients with Intracranial Atherosclerosis in China: Subgroup Analysis from the Chinese Intracranial Atherosclerosis Study

Pu Y, Wei N, Yu D, Wang Y, Zou X, Soo YOY, Pan Y, Leung TWH, Wong LKS, Wang Y, Liu L.
Neuroepidemiology. 2017;18(1-2):48-54.

Principles of precision medicine in stroke

Hinman JD, Rost NS, Leung TW, Montaner J, Muir KW, Brown S, Arenillas JF, Feldmann E, Liebeskind DS
J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):54-61. doi: 10.1136/jnnp-2016-314587. Epub 2016 Oct 19. PMID: 27919057.