People
Prof. Vincent CT MOK
The Chinese University of Hong Kong
Master of S.H. Ho College
Endowed Mok Hing Yiu Professor of Medicine
Co-Director, Charles Kao CUHK BEAT AD Service
Director, Lau Tat-Chuen Research Centre of Brain Degenerative Diseases in Chinese
Director, Margaret K.L. Cheung Research Centre for Management of Parkinsonism
Director, Therese Pei Fong Chow Research Centre for Prevention of Dementia
Programme Director, MSc Programme in Stroke and Clinical Neurosciences (MCNS)
Programme Co-Director, Professional Certificate Programme in Promoting Well-being in Informal Caregivers of Dementia (GIFTCare)
Member of Department Academic Personnel Committee (DAPC), Department of Medicine and Therapeutics
Head of Division of Neurology (Academic Affairs), Department of Medicine and Therapeutics (2016-2022)
Prince of Wales Hospital
Specialist in Neurology
Honorary Consultant, Department of Medicine and Therapeutics
Academic and Professional Qualifications
MBBS (Syd), MD (CUHK), FRCP (London, Edin), FHKAM (Medicine), FHKCP, MRCP (UK)Biography
Prof. Vincent Mok's research aims to understand mechanisms of dementia and to investigate strategies that may help to prevent dementia. He is the first to report the association of cerebral small vessel disease (CSVD) and cognitive impairment in Asia and the first to report the community prevalence of CSVD among Asians (Chinese). Such findings have significantly increased the awareness that strategies targeting CSVD (e.g. blood pressure lowering) can help to prevent dementia in this region, where the burden of dementia is particularly huge. Prof. Mok conducted one of the largest single-centre studies investigating the prevalence and mechanisms of early and delayed cognitive decline in the context of stroke and found that concurrent presence of amyloid plaques as detected by in-vivo amyloid PET imaging and CSVD are important factors associated with early and delayed cognitive decline after stroke, respectively. Such findings provide a road map of how to prevent vascular cognitive impairment. Prof. Mok, along with Dr Adrian Wong (Clinical Psychologist) validated the Hong Kong-Montreal Cognitive Assessment (HK-MoCA) and developed norms for HK-MoCA performance according to age and education. HK-MoCA is currently the commonest brief cognitive assessment used for the assessment of cognitive function and the detection of mild cognitive impairment in HK.
Prof. Mok has been involved in the validation and clinical application of a novel artificial intelligence (AI) derived MRI-based Index, which was developed by a spin-off company of the Chinese University of Hong Kong (CUHK), for the detection of early Alzheimer’s disease. He has also been involved in developing and validating an AI derived retinal imaging analysis for the detection of Alzheimer’s disease. Moreover, he also specializes in Parkinson's disease and was one of the pioneers of developing Deep Brain Stimulation programme in Asia for the treatment of Parkinson’s disease.
He received the Higher Education Outstanding Scientific Research Output Award (Science & Technology) in Natural Sciences (1st Class) from the Ministry of Education, People's Republic of China in 2011 for his research in cerebrovascular disease, Outstanding Fellow Award from the Faculty of Medicine of CUHK for his exceptional academic leadership in areas of research, education and service in 2016, Endowment as Mok Hing Yiu Professor of Medicine by CUHK in 2017, the Excellent Research Award and the 10th Health and Medical Research Fund Anniversary Award by the Food and Health Bureau of the Hong Kong Special Administrative Region (HKSAR) for his research in vascular cognitive impairment in 2017 and 2021, respectively. He was conferred the Chief Executive’s Commendation for Community Service by the Government of the HKSAR in 2022 for his contribution in combating COVID-19 pandemic. He was appointed as the Master of the S.H. Ho College in 2022. He received 7 times Teacher of the Year Award and the Master Teacher Award from the Faculty from the Faculty of Medicine, CUHK. He was also one of the pioneers in developing the Global Physician Leadership Stream (GPS) programme, which is a flagship undergraduate programme of the Faculty in providing medical leadership training and exposures for medical students. As a core member of the founding GPS team, the Faculty and University awarded him the prestigious Faculty Education Award (Collaborative Team) and University Education Award (Collaborative Team) in 2023, respectively.
Prof. Mok has authored more than 400 publications in peer-reviewed international journals (with book chapters), with publications at Lancet, JAMA, Lancet Neurology, Nature Reviews Neurology, Alzheimer’s & Dementia, JAMA Neurology, JAMA Psychiatry, Journal of Neurology, Neurosurgery and Psychiatry (JNNP), Annals of Neurology, Neurology and Stroke.
Prof. Vincent CT MOK
The Chinese University of Hong Kong
Master of S.H. Ho College
Endowed Mok Hing Yiu Professor of Medicine
Co-Director, Charles Kao CUHK BEAT AD Service
Director, Lau Tat-Chuen Research Centre of Brain Degenerative Diseases in Chinese
Director, Margaret K.L. Cheung Research Centre for Management of Parkinsonism
Director, Therese Pei Fong Chow Research Centre for Prevention of Dementia
Programme Director, MSc Programme in Stroke and Clinical Neurosciences (MCNS)
Programme Co-Director, Professional Certificate Programme in Promoting Well-being in Informal Caregivers of Dementia (GIFTCare)
Member of Department Academic Personnel Committee (DAPC), Department of Medicine and Therapeutics
Head of Division of Neurology (Academic Affairs), Department of Medicine and Therapeutics (2016-2022)
Prince of Wales Hospital
Specialist in Neurology
Honorary Consultant, Department of Medicine and Therapeutics
Research Interests
- Mechanisms and therapeutics of common age related cognitive disorders, e.g., Alzheimer’s disease, Vascular Cognitive Impairment, Cerebral Small Vessel Disease, Mixed Dementia
- Artificial intelligence aided technology based on MRI and retinal imaging for diagnosis, prognostication, and monitoring of brain diseases
- Parkinson's disease - premotor stage, genetics, neuroimaging, and Deep Brain Stimulation
Honorary Appointments in Other Professional Activities
- Member of the Steering Committee for Dementia Research Centre, LKC School of Medicine, Nanyang Technological University, Singapore, 2024 - present
- Core Team Member of the Expert Group on Drug Registration of the Pharmacy and Poisons Board, Department of Health, The Government of the Hong Kong Special Administrative Region, 2024 - present
- Panel Member of The Human Organ Transplant Board, The Government of the Hong Kong Special Administrative Region, 2024 - present
- Panel Member of 23rd NEJM Frontiers in Medicine Monthly Meeting focusing on Alzheimer's and dementia, August 2023
- Expert Member (Hong Kong Region) of Eisai Alzheimer’s Disease Advisory Board on Lecanemab, 2023
- Chairman of the Specialty Board of Neurology, Hong Kong College of Physicians, 2023 - present
- Member of the Education and Accreditation Committee, Hong Kong College of Physicians, 2023 - present
- Member of Guardianship Board, The Government of the Hong Kong Special Administrative Region, 2022 - present
- Chairman of Wong Tai Sin District Health Centre Advisory Committee, 2022 - present
- Member of the Scientific Advisory Board for the Open Fund Large Collaborative Grant Programme, National Medical Research Council, Ministry of Health, Singapore, 2021 - 2026
- Advisory Council Member of Charles K. Kao Foundation for Alzheimer’s Disease, 2021 - present
- Member of the Expert Committee on Clinical Events Assessment Following COVID-19 Immunisation, The Government of the Hong Kong Special Administrative Region, 2021 - present
- Chair of the Local Organizing Committee of the 9th International Meeting of the International Society of Vascular Behavioural and Cognitive Disorders, HKSAR, 2018
- Co-Chair of the Congress Scientific Program Committee of 2018 International Congress of the International Parkinson's Disease and Movement Disorder Society, HKSAR, 2018
- Secretary of the Neurology Specialty Board, Hong Kong College of Physicians, 2018 – 2023
- Advisory Council Member of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), 2018 – 2020
- Vice-Chair and Hong Kong Representative of the China Greater Bay Guang Zhou-Hong Kong-Macau Neurology Alliance, 2018
- Hong Kong Representative of the World Federation of Neurology, 2012 – 2021
- Executive Committee Member of the International Society of Vascular Behavioral and Cognitive Disorders, 2011 –Present
- Honorary Treasurer of the Asian Society Against Dementia, 2011 – Present
- Chair of the Scientific Program Committee of the 2017 Asia Pacific Stroke Conference, Nanjing China, 2017
- President of the Chinese Dementia Research Association, 2015 – 2016
- Member of Working Group of European Union-Joint Programme Neurodegenerative Disease (EU-JPND) Research in Longitudinal Cohorts, 2015
- Member of the Stroke Progress Review Group in Vascular Cognitive Member of the Stroke Progress Review Group in Vascular Cognitive Impairment of the National Institute of Neurological Diseases and Stroke of United States of America, 2012
- President of the Hong Kong Movement Disorder Society, 2011 – 2013
Awards
- University Education Award (Collaborative Teams) 2022-23
- Faculty Education Award (Collaborative Teams) 2022-23
- Faculty Outstanding Research Output Award, LKS Faculty of Medicine, The University of Hong Kong (2022)
- Chief Executive’s Commendation for Community Service 2022, HKSAR (2022)
- 10th Health and Medical Research Fund Anniversary Award, HKSAR (2021)
- Excellent Research Award, Food & Health Bureau, HKSAR (2017)
- Outstanding Fellow of Faculty of Medicine, CUHK (2016)
- Ministry of Education Higher Education Outstanding Scientific Research Output Award - First-class Award in Natural Sciences (2011 )
- Master Teacher Award, CUHK (2012)
- Teacher of the Year Award for 7 times, CUHK (2005-2012)
Selected Publications
- Cheung CY, Ran AR, Wang S, Chan VTT, Sham K, Hilal S, Venketasubramanian N, Cheng CY, Sabanayagam C, Tham YC, Schmetterer L, McKay GJ, Williams MA, Wong A, Au LWC, Lu Z, Yam JC, Tham CC, Chen JJ, Dumitrascu OM, Heng PA, Kwok TCY, Mok VCT, Milea D, Chen CL, Wong TY. A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study. Lancet Digital Health. 2022 Nov;4(11):e806-e815. doi: 10.1016/S2589-7500(22)00169-8.
- Lam BYK, Cai Y, Akinyemi R, Biessels GJ, van den Brink H, Chen C, Cheung CW, Chow KN, Chung HKH, Duering M, Fu ST, Gustafson D, Hilal S, Hui VMH, Kalaria R, Kim S, Lam MLM, de Leeuw FE, Li ASM, Markus HS, Marseglia A, Zheng H, O'Brien J, Pantoni L, Sachdev PS, Smith EE, Wardlaw J, Mok VCT. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis. International Journal of Stroke. 2023 Jan;18(1):15-27. doi: 10.1177/17474930221137019.
- Fan FSY, Yip TCF, Yiu B, Lam B, Au L, Lau AYL, Ip B, Soo Y, Leung TWH, Li T, Lui G, Wong GLH, Mok VCT. Neurological diseases and risk of mortality in patients with COVID-19 and SARS: a territory-wide study in Hong Kong. J Neurol Neurosurg Psychiatry. 2021 Apr 27;jnnp-2021-326286.
- Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL. Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186.
- Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath P, GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim SY, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P. Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimer's & Dementia. 2020 Aug 12;doi:10.1002/alz.12143.
- Kang D, Wong A, Fu J, Qun X, Liu W, Wang Z, Lin S, Kwan P, Lo E, Au LWC, Ko H, Lau AYL, Leung TWH, Abrigo J, Chu WCW, Mok VCT, Lam BYK. Can transcranial Doppler ultrasound be used for screening cerebral small vessel diseases in the community? J Neurol Sci. 2019 Aug 29;406:116439. doi: 10.1016/j.jns.2019.116439. [Epub ahead of print].
- Zhao L, Luo Y, Lew D, Liu W, Au L, Mok V, Shi L; Alzheimer Disease Neuroimaging Initiative. Risk estimation before progression to mild cognitive impairment and Alzheimer's disease: an AD resemblance atrophy index. Aging (Albany NY). 2019 Aug 29;11(16):6217-6236. doi: 10.18632/aging.102184. Epub 2019 Aug 29.
- Cummings J, Passmore P, McGuinness B, Mok V, Chen C, Engelborghs S, Woodward M, Manzano S, Garcia-Ribas G, Cappa S, Bertolucci P, Chu LW. Souvenaid in the management of mild cognitive impairment: an expert consensus opinion. Alzheimers Res Ther. 2019 Aug 17;11(1):73. doi: 10.1186/s13195-019-0528-6. Review.
- Wong A, Yiu S, Lam BYK, Leung KT, Shi L, Lo E, Abrigo J, Au LW, Lau A, Mok V. Physical activities attenuate the negative cognitive impact from white matter hyperintensities in stroke and TIA patients with low education. Int J Geriatr Psychiatry. 2019 Aug 13. doi: 10.1002/gps.5194. [Epub ahead of print]
- Au LWC, Chan AYY, Mok VCT. Teaching NeuroImages: X-linked adrenoleukodystrophy: Spinocerebellar variant. Neurology. 2019 Aug 13;93(7):e731-e732. doi: 10.1212/WNL.0000000000007958. No abstract available.
- Yu JT, Li JQ, Suckling J, Feng L, Pan A, Wang YJ, Song B, Zhu SL, Li DH, Wang HF, Tan CC, Dong Q, Tan L, Mok V, Aisen PS, Weiner MM; Alzheimer's Disease Neuroimaging Initiative. Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study. Alzheimers Dement. 2019 Sep;15(9):1208-1217. doi: 10.1016/j.jalz.2019.05.006. Epub 2019 Aug 6.
- Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.
- Wilson D, Ambler G, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sánchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Schrooten M, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Assayag EB, Hallevi H, Tanaka J, Hara H, Coutts SB, Hert L, Polymeris A, Seiffge DJ, Lyrer P, Algra A, Kappelle J, Al-Shahi Salman R, Jäger HR, Lip GYH, Mattle HP, Panos LD, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Kooi ME, van Dam-Nolen DHK, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra C, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, van der Lugt A, Kelly PJ, Wardlaw JM, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23.
- Shi L, Lou W, Wong A, Zhang F, Abrigo J, Chu WC, Kwok TC, Wong KK, Abbott D, Wang D, Mok VC. Neural evidence for long-term marriage shaping the functional brain network organization between couples. Neuroimage. 2019 Oct 1;199:87-92. doi: 10.1016/j.neuroimage.2019.05.058. Epub 2019 May 23.
- Kwok JYY, Kwan JCY, Auyeung M, Mok VCT, Lau CKY, Choi KC, Chan HYL. Effects of Mindfulness Yoga vs Stretching and Resistance Training Exercises on Anxiety and Depression for People With Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2019 Jul 1;76(7):755-763. doi: 10.1001/jamaneurol.2019.0534.
- Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem MA, DeCarli C, Ding D, Gudnason V, Hara H, Imaizumi T, Kohara K, Kwon HM, Launer LJ, Mok V, Phan T, Preis SR, Romero JR, Seshadri S, Srikanth V, Takashima Y, Tsushima Y, Wang Z, Wolf PA, Xiong Y, Yamaguchi S, Werring DJ. Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis. Neurology. 2019 Mar 5;92(10):e1086-e1097. doi: 10.1212/WNL.0000000000007039. Epub 2019 Feb 1. Erratum in: Neurology. 2019 Jul 2;93(1):46.
- Lau AY, Mok V, Lee J, Fan Y, Zeng J, Lam B, Wong A, Kwok C, Lai M, Zee B. Retinal image analytics detects white matter hyperintensities in healthy adults. Ann Clin Transl Neurol. 2018 Nov 15;6(1):98-105. doi: 10.1002/acn3.688. eCollection 2019 Jan.
- Abrigo J, Shi L, Luo Y, Chen Q, Chu WCW, Mok VCT; Alzheimer’s Disease Neuroimaging Initiative. Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker. Acta Radiol. 2019 Jun;60(6):769-776. doi: 10.1177/0284185118795327. Epub 2018 Sep 5.
- Shi L, Zhao L, Yeung FK, Wong SY, Chan RKT, Tse MF, Chan SC, Kwong YC, Li KC, Liu K, Abrigo JM, Lau AYL, Wong A, Lam BYK, Leung TWH, Fu J, Chu WCW, Mok VCT. Mapping the contribution and strategic distribution patterns of neuroimaging features of small vessel disease in poststroke cognitive impairment. J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):918-926. doi: 10.1136/jnnp-2017-317817. Epub 2018 Apr 17.