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Research

Grants

From 2021 onwards

Dr. Owen Ko

Principal Investigator
HKD 3,926,000

Development and Preclinical Test of Optical Pumping-based Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging for Diagnosis of Neurological Diseases

Partnership Research Programme, Innovation and Technology Fund of the Innovation and Technology Commission of Hong Kong
2022 - 2025

Prof. Vincent Mok

Co-Investigator
HKD 1,154,476

Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study

General Research Fund, University Grants Committee
2021 - 2024

Prof. Vincent Mok

Co-Investigator
HKD 1,112,120

Neural correlates of impulsivity in idiopathic REM sleep behavior disorder: a functional Magnetic Resonance Imaging case-control study

Health and Medical Research Fund, Hong Kong Food and Health Bureau
2021 - 2024

Dr. Owen Ko

Principal Investigator
RMB 2,000,000

Anti-aging Effects of GLP-1R Agonism and Companion Non-invasive Diagnostics

Excellent Young Scientists Fund (Hong Kong and Macau), National Natural Science Foundation of China
2021 - 2024

Dr. Owen Ko

Principal Investigator
RMB 1,000,000

Development of Novel Therapeutics Drug for Niemann-Pick Disease, Type C

Science, Technology and Innovation Commission of Shenzhen Municipality
2021 - 2024

Dr. Owen Ko

Co-Investigator
HKD 4,700,000

Clearing the Way for Better Tissue Diagnostics - a Midstream Development Project on Accessible Three-dimensional Histology Methods and Platform

Midstream Research Programme, Hong Kong Innovation and Technology Council
2021 - 2024

Prof. Vincent Mok

Co-Investigator
HKD 1,104,304

Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behavior Disorder: tracing a subtype of depression with underlying neurodegeneration

Health and Medical Research Fund, Hong Kong Food and Health Bureau
2021 - 2023

Prof. Vincent Mok

Principal Investigator
HKD 1,338,540

Development and Clinical Application of Early Warning Platform for Cognitive Impairment in Parkinson’s Disease

Guangdong-Hong Kong Technology Cooperation Funding Scheme, Innovation and Technology Commission
2021 - 2023

Dr. Owen Ko

Principal Investigator
HKD 911,140

Novel MRI-based Machine Learning Tool to Detect Mild Cognitive Impairment Associated with Alzheimer’s Disease

Health and Medical Research Fund, Hong Kong Food and Health Bureau
2021 - 2023

Dr. Owen Ko

Co-Investigator
HKD 965,803

A Comprehensive Survey on Alpha-Synuclein Pathologies in Colonic Submucosal Biopsies of Prodromal Parkinson’s Disease Patients – An Exploratory Study

Health and Medical Research Fund, Hong Kong Food and Health Bureau
2021 - 2023

Dr. Owen Ko

Co-Principal Investigator
HKD 1,063,000

Construction of a MesoSPIM Light Sheet Microscope

Academic Equipment Grant, CUHK
2021

Dr. Karen Ma

Principal Investigator
HKD 200,000

Neuroimaging Biomarkers in Parkinsonian Syndromes

Hong Kong Neurological Society Research Grant, Hong Kong Neurological Society
2021

Dr. Bonaventure Ip

Young Investigator Research Grant, The Hong Kong College of Physicians
2021

Publications

2022

Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

Zhao L, Zhang CL, He L, Chen Q, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L, Huang Y
Diabetes. 2022 May 1;71(5):1099-1114. doi: 10.2337/db21-0660. PMID: 35179568.

Small vessel disease burden may not portend unfavorable outcome after thrombectomy for acute large vessel occlusion

Zheng L, Leng X, Nie X, Yan H, Tian X, Pan Y, Yang Z, Wen M, Pu Y, Gu W, Miao Z, Leung TW, Liu L
Eur Radiol. 2022 Apr 27. doi: 10.1007/s00330-022-08795-3. Epub ahead of print. PMID: 35475935.

Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Biesbroek JM, Weaver NA, Aben HP, Kuijf HJ, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Valdés-Hernández MDC, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biessels GJ
Neuroimage Clin. 2022 Apr 27;34:103018. doi: 10.1016/j.nicl.2022.103018. Epub ahead of print. PMID: 35504223; PMCID: PMC9079101.

Effects of Mindfulness Yoga Versus Conventional Physical Exercises on Symptom Experiences and Health-related Quality of Life in People with Parkinson's Disease: The Potential Mediating Roles of Anxiety and Depression

Kwok JYY, Choi EPH, Lee JJ, Lok KYW, Kwan JCY, Mok VCT, Auyeung M.
Ann Behav Med. 2022 Apr 23:kaac005. doi: 10.1093/abm/kaac005. Epub ahead of print. PMID: 35460239.

Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk

Cao H, Zhou X, Chen Y, Ip FCF, Chen Y, Lai NCH, Lo RMN, Tong EPS, Mok VCT, Kwok TCY; Alzheimer’s Disease Neuroimaging Initiative, Fu AKY, Ip NY
J Alzheimers Dis. 2022;86(4):1861-1873. doi: 10.3233/JAD-215311. PMID: 35253752.

Cost-Effectiveness of Monitoring Patients Post-Stroke With Mobile ECG During the Hospital Stay

Gao L, Moodie M, Freedman B, Lam C, Tu H, Swift C, Ma SH, Mok VCT, Sui Y, Sharpe D, Ghia D, Jannes J, Davis S, Liu X, Yan B.
J Am Heart Assoc. 2022 Apr 19;11(8):e022735. doi: 10.1161/JAHA.121.022735. Epub 2022 Apr 12. PMID: 35411782.

Evaluation of oropharyngeal deglutitive pressure dynamics in patients with Parkinson's disease

Szczesniak MM, Omari TI, Lam TY, Wong M, Mok VCT, Wu JCY, Chiu PWY, Yuen MTY, Tsang RK, Cock C, Sung JJ, Wu P.
Am J Physiol Gastrointest Liver Physiol. 2022 Apr 1;322(4):G421-G430. doi: 10.1152/ajpgi.00314.2021. Epub 2022 Feb 9. PMID: 35138164.

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.

Jansen WJ … Mok VCT … Zetterberg H
JAMA Neurol. 2022 Mar 1;79(3):228-243. doi: 10.1001/jamaneurol.2021.5216. Erratum in: JAMA Neurol. 2022 Mar 1;79(3):313. PMID: 35099509.

Intracranial Arterial Calcification and Intracranial Atherosclerosis: Close but Different

Du H, Li J, Yang W, Bos D, Zheng L, Wong LKS, Leung TW, Chen X
Front Neurol. 2022 Feb 8;13:799429. doi: 10.3389/fneur.2022.799429. PMID: 35211084; PMCID: PMC8861312.

Barriers to generic antiseizure medication use: Results of a global survey by the International League Against Epilepsy Generic Substitution Task Force

Niyongere J, Welty TE, Bell MW, Consalvo D, Hammond C, Leung H, Patsalos PN, Ryan M, Suansanae T, Zhou D, Zuellig H
Epilepsia Open. 2022;00:1– 11.

Effects of functional task exercise on everyday problem-solving ability and functional status in older adults with mild cognitive impairment-a randomised controlled trial

Law LLF, Mok VCT, Yau MKS, Fong KNK
Age Ageing. 2022 Jan 6;51(1):afab210. doi: 10.1093/ageing/afab210. PMID: 34673918.

Vertebrobasilar Junction Angle Over 90°: A Potential Imaging Marker Associated With Vertebrobasilar Atherosclerosis

Li J, Yang WJ, Zheng L, Du H, Chu WC, Leung TW, Chen XY
Front Neurosci. 2022 Jan 5;15:789852. doi: 10.3389/fnins.2021.789852. PMID: 35069103; PMCID: PMC8766791.

Primary stroke prevention worldwide: translating evidence into action.

Owolabi MO, Thrift AG, Mahal A, Ishida M, Martins S, Johnson WD, Pandian J, Abd-Allah F, Yaria J, Phan HT, Roth G, Gall SL, Beare R, Phan TG, Mikulik R, Akinyemi RO, Norrving B, Brainin M, Feigin VL; Stroke Experts Collaboration Group
Lancet Public Health. 2022 Jan;7(1):e74-e85. doi: 10.1016/S2468-2667(21)00230-9

Bell’s palsy following vaccination with mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines: a case series and nested case-control study

Wan EYF, Chui CSL, Lai FTT, Chan EWY, Xue Li, Yan VKC, Gao L, Yu Q, Lam ICH, Chun RKC, Cowling BJ, Fong WC, Lau AYL, Mok VCT, Chan FLF, Lee CK, Chan LST, Lo D, Lau KK, Hung IFN, Leung GM, Wong ICK
Lancet Infect Dis. 2022; 22: 64–72.

2021

Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial

WONG A, LAM BYK, MAK MKY, LAM LCW, AU LWC, YIU BKF, WONG C, TONG HY, YEUNG SK, CHU WCW, SHI L, LEUNG TWH, SOO YOY, LAU AYL, IP BYM, KWOK TCY, KO H, MOK VCT.
Alzheimer’s Dement. 2021;7:e12224.

Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion

Nie X, Wang D, Pu Y, Wei Y, Lu Q, Yan H, Liu X, Zheng L, Liu J, Yang X, Ding Y, Liu D, Duan W, Zhang Z, Yang Z, Wen M, Gu W, Hou X, Leng X, Pan Y, Miao Z, Liu L(corresponding author)
Stroke Vasc Neurol. 2021;0. doi:10.1136/ svn-2021-001242

Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

Shi M, Leng X, Li Y, Chen Z, Cao Y, Chung T, Ip BY, Ip VH, Soo YO, Fan FS, Ma SH, Ma K, Chan AYY, Au LW, Leung H, Lau AY, Mok VC, Choy KW, Dong Z, Leung TW
Stroke Vasc Neurol. 2021 Dec 8;svn-2021-001157. doi: 10.1136/svn-2021-001157.

Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer's disease

Li Z, Ip B, Mok VCT, Ko H
Neural Regen Res. 2021 Dec;16(12):2411-2412. doi: 10.4103/1673-5374.313042.

Diffusion MRI harmonization enables joint-analysis of multicentre data of patients with cerebral small vessel disease

de Brito Robalo BM, Biessels GJ, Chen C, Dewenter A, Duering M, Hilal S, Koek HL, Kopczak A, Yin Ka Lam B, Leemans A, Mok V, Onkenhout LP, van den Brink H, de Luca A.
Neuroimage Clin. 2021;32:102886. doi: 10.1016/j.nicl.2021.102886.

Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study

Wang J; Chau SWH, Lam SP, Liu YP, Zhang JH, Chan NY, Cheung MMS, Yu MWM, Tsang JCT, Chan JWY, Huang B, Li SX, Mok V, Wing YK
Journal of Neurology Neurosurgery and Psychiatry. 11 Nov 2021.

The state of stroke services across the globe: Report of World Stroke Organization-World Health Organization surveys

Owolabi MO, Thrift AG, Martins S, Johnson W, Pandian J, Abd-Allah F, Varghese C, Mahal A, Yaria J, Phan HT, Roth G, Gall SL, Beare R, Phan TG, Mikulik R, Norrving B, Feigin VL; Stroke Experts Collaboration Group
Int J Stroke. 2021 Oct;16(8):889-901. doi: 10.1177/17474930211019568.

Comparison of Newtonian and Non-newtonian Fluid Models in Blood Flow Simulation in Patients With Intracranial Arterial Stenosis

Liu H, Lan L, Abrigo J, Ip HL, Soo Y, Zheng D, Wong KS, Wang D, Shi L, Leung TW, Leng X
Front Physiol. 2021 Sep 6;12:718540. doi: 10.3389/fphys.2021.718540.

International Survey of Mechanical Thrombectomy Stroke Systems of Care During COVID-19 Pandemic

Yavagal DR, Saini V, Inoa V, Gardener HE, Martins SO, Fakey M, Ortega S, Mansour O, Leung T, Al-Mufti F, Jadhav AP, Potter-Vig J, Mairal A, Zhongrong M, Sylaja PN, Demchuk AM; MT2020 Global Executive Committee
J Stroke Cerebrovasc Dis. 2021 Aug;30(8):105806. doi: 10.1016/j.jstrokecerebrovasdis.2021.105806.

Understanding the Clinical Implications of Intracranial Arterial Calcification Using Brain CT and Vessel Wall Imaging

Yang WJ, Wasserman BA, Zheng L, Huang ZQ, Li J, Abrigo J, Wong SS, Ying MT, Chu WC, Wong LK, Leung TW and Chen XY.
Front Neurol . 15 July 2021. DOI: 10.3389/fneur.2021.619233.

Risk factors for delayed-onset dementia after stroke or transient ischemic attack-A five-year longitudinal cohort study

Ismail M, Mok VC, Wong A, Au L, Yiu B, Wang Z, Chu WC, Chan AY, Fan FS, Ma SH, Ip V, Ip B, Ma K, Leung H, Soo YO, Leung TW, Ko H, Lau AY, Lam BY
Int J Stroke. 2021 Jul 2:17474930211026519. doi: 10.1177/17474930211026519.

Global impact of COVID-19 on stroke care

Nogueira RG … Leung T… Nguyen TN.
Int J Stroke. . 2021 Jul;16(5):573-584. doi: 10.1177/1747493021991652

A prediction of hematoma expansion in hemorrhagic patients using a novel dual-modal machine learning strategy

Cheng X, Zhang W, Wu ML, Jiang N, Guo ZN, Leng X, Song JN, Jin H, Sun X, Zhang F, Qin J, Yan X, Cai Z, Luo Y, Yang Y, Liu J
Physiol Meas. 2021 Jul 1. doi: 10.1088/1361-6579/ac10ab. Online ahead of print.

Retinal imaging in Alzheimer’s disease

Cheung CY, Mok V, Foster PJ, Trucco E, Chen C, Wong TY
J Neurol Neurosurg Psychiatry . 2021;92:983–994.

Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

Nogueira RG … Leung T… Nguyen TN.
Neurology. 2021 Jun 8;96(23):e2824-e2838. doi: 10.1212/WNL.0000000000011885.

Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images

Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee A, Kwok C, Lai M, Mok V, Lau A
Brain Commun. 2021 Jun 3;3(3):fcab124. doi: 10.1093/braincomms/fcab124. PMID: 34222872; PMCID: PMC8249101.

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H
Communications Biology. 2021 Jun 2;4(1)656.

High burden of cerebral white matter lesion in 9 Asian cities

Lam BYK, Yiu B, Ampil E, Chen CL, Dikot Y, Dominguez JC, Ganeshbhai PV, Hilal S, Kandiah N, Kim S, Lee JY, Ong AP, Senanarong V, Leung KT, Wang H, Yang YH, Yong T, Arshad F, Alladi S, Wong S, Ko H, Lau AYL, Mok VCT
Sci Rep. 2021 Jun 2;11(1):11587. doi: 10.1038/s41598-021-90746-x.

Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease

Au CKF, Abrigo J, Liu C, Liu W, Lee J, Au LWC, Chan Q, Chen S, Leung EYL, Ho CL, Ko H, Mok VCT, Chen W
J Magn Reson Imaging. 2021 Jun;53(6):1823-1832. doi: 10.1002/jmri.27464.

Super-refractory status epilepticus in autoimmune encephalitis treated with interleukin-1 receptor antagonist, anakinra

Choi CH, Ma SH, Ma KK, Leung H, Mok VC
Epileptic Disord. 2021 Jun 1;23(3):500-505. doi: 10.1684/epd.2021.1283.

Validation of a translated Chinese version of the Participation Strategies Self-Efficacy Scale: a cross-sectional study

Chau JPC, Lo SHS, Zhao J, Choi KC, Lam SKY, Saran R, Shi J, Thompson DR, Lau AYL
Disabil Rehabil. 2021 Jun 1:1-7. doi: 10.1080/09638288.2021.1933220.

Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts

Weaver NA, Kuijf HJ, Aben HP, Abrigo J, Bae HJ, Barbay M, Best JG, Bordet R, Chappell FM, Chen CPLH, Dondaine T, van der Giessen RS, Godefroy O, Gyanwali B, Hamilton OKL, Hilal S, Huenges Wajer IMC, Kang Y, Kappelle LJ, Kim BJ, Köhler S, de Kort PLM, Koudstaal PJ, Kuchcinski G, Lam BYK, Lee BC, Lee KJ, Lim JS, Lopes R, Makin SDJ, Mendyk AM, Mok VCT, Oh MS, van Oostenbrugge RJ, Roussel M, Shi L, Staals J, Del C Valdés-Hernández M, Venketasubramanian N, Verhey FRJ, Wardlaw JM, Werring DJ, Xin X, Yu KH, van Zandvoort MJE, Zhao L, Biesbroek JM, Biessels GJ
Lancet Neurol. 2021 Jun;20(6):448-459. doi: 10.1016/S1474-4422(21)00060-0.

Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL
ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186.

MRI-based Alzheimer's disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer's disease

Liu W, Au LWC, Abrigo J, Luo Y, Wong A, Lam BYK, Fan X, Kwan PWL, Ma HW, Ng AYT, Chen S, Leung EYL, Ho CL, Wong SHM, Chu WC, Ko H, Lau AYL, Shi L, Mok VCT; Alzheimer’s Disease Neuroimaging Initiative
Aging (Albany NY). 2021 May 25;13(10):13496-13514. doi: 10.18632/aging.203082. . https://pubmed.ncbi.nlm.nih.gov/34091443/

Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NCH, Cheung K, Lo RMN, Tong EPS, Wong BWY, Chan ALT, Mok VCT, Kwok TCY, Mok KY, Hardy J, Zetterberg H, Fu AKY, Ip NY
Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12369.

Erratum

Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai MC, Pantoni L, Sachdev P, Senanarong V, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P
Alzheimers Dement. 2021 May;17(5):906-907. doi: 10.1002/alz.12307.

Neurological diseases and risk of mortality in patients with COVID-19 and SARS: a territory-wide study in Hong Kong

Fan FSY, Yip TCF, Yiu B, Lam B, Au L, Lau AYL, Ip B, Soo Y, Leung TWH, Li T, Lui G, Wong GLH, Mok VCT
J Neurol Neurosurg Psychiatry. 2021 Apr 27;jnnp-2021-326286.

The Use of Cabozantinib in Advanced Hepatocellular Carcinoma in Hong Kong-A Territory-Wide Cohort Study

Wong JS, Dong Y, Tang V, Leung T, Yeung CSY, Tai A, Law A, Shum T, Kwok GG, Li BC, Leung R, Chiu J, Ma KW, She WH, Tsang J, Cheung TT, Yau T
Cancers (Basel). 2021 Apr 21;13(9):2002. doi: 10.3390/cancers13092002.

Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients

Chan KL, Feng X, Ip B, Huang S, Ma SH, Fan FSY, Ip HL, Huang L, Mok VCT, Soo YOY, Leung TW, Leng X
Front Aging Neurosci. 2021 Apr 20;13:646961. doi: 10.3389/fnagi.2021.646961.

Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir

Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony K. N. Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis K. L. Chan, David S. C. Hui, Vincent C. T. Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, and Wai-Lung Ng
ACS Cent Sci. 2021 April 15;doi.org/10.1021/acscentsci.0c01186.

Evolving ischemic stroke subtypes in 15 years: A hospital-based observational study

Ip B, Au L, Chan AYY, Fan F, Ip V, Ma SH, Ma K, Mok VCT, Lau A, Leng X, Leung H, Wong A, Abrigo J, Wong J, Yu S, Wong KS, Soo YOY, Leung TWH
Int J Stroke. 2021 Apr 7;17474930211005953. doi: 10.1177/17474930211005953.

Prevalence and predictors of mood disturbances in idiopathic REM sleep behaviour disorder

Chiu NKH, Ehgoetz Martens KA, Mok VCT, Lewis SJG, Matar E
J Sleep Res. . 2021 Apr;30(2):e13040. doi: 10.1111/jsr.13040.

A Data-Driven Approach to Transfer Function Analysis for Superior Discriminative Power: Optimized Assessment of Dynamic Cerebral Autoregulation

Liu J, Guo ZN, Simpson D, Zhang P, Liu C, Song JN, Leng X, Yang Y
IEEE J Biomed Health Inform. 2021;25:909-921.

Development of image-based risk scores for prediction of intracranial hemorrhage and ischemic stroke in patients taking antithrombotic therapy after ischemic stroke or transient ischemic attack: a pooled analysis of individual patient data from cohort studies

Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sanchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Ben Assayag E, Hallevi H, Molad J, Nishihara M, Tanaka J, Coutts SB, Polymeris A, Wagner B, Seiffge DJ, Lyrer P, Algra A, Kappelle LJ, Al-Shahi Salman R, Jäger HR, Lip GYH, Fischer U, El-Koussy M, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Mess WH, Nederkoorn PJ, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra AC, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, Hendrikse J, Kelly PJ, Wardlaw J, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Hara H, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network
Lancet Neurol. 2021 Apr;20(4):294-303. doi: 10.1016/S1474-4422(21)00024-7.

Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry

Jia B, Ren Z, Mokin M, Burgin WS, Bauer CT, Fiehler J, Mo D, Ma N, Gao F, Huo X, Luo G, Wang A, Pan Y, Song L, Sun X, Zhang X, Gui L, Song C, Peng Y, Wu J, Zhao S, Zhao J, Zhou Z, Li Y, Jing P, Yang L, Liu Y, Zhao Q, Liu Y, Peng X, Gao Q, Guo Z, Chen W, Li W, Cheng X, Xu Y, Zhang Y, Zhang G, Lu Y, Lu X, Wang D, Wang Y, Li H, Ling L, Peng G, Zhang J, Zhang K, Li S, Qi Z, Xu H, Tong X, Ma G, Liu R, Guo X, Deng Y, Leng X, Leung TW, Liebeskind DS, Wang Y, Wang Y, Miao Z; ANGEL-ACT Study Group
Stroke. 2021 Apr;52(4):1203-1212. doi: 10.1161/STROKEAHA.120.031869.

Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review

Leng XY, Hurford R, Feng XY, Chan KY, Wolters FJ, Li LX, Soo YOY, Wong LKS, Mok VCT, Leung TWH, Rothwell PM
J Neurol Neurosurg Psychiatry. 2021 Mar 30; doi: 10.1136/jnnp-2020-325630.

Teaching Video NeuroImages: A Triad of Tremor, Ataxia, and Cognitive Impairment

Au LWC, Ho K, Li JJX, Mok VCT
Neurology. 2021 Mar 30;96(13):e1802-e1803. doi: 10.1212/WNL.0000000000011288.

A retrospective comparison of cognitive performance in individuals with advanced Parkinson's Disease in Hong Kong and Canada

Kwan V, Shum D, Haffenden A, Yeates KO, Kwok A, Lau H, Poon WS, Chan D, Zhu XL, Chan D, Mok V, Chan A, Ma K, Yeung J, Lau C, Bezchlibnyk Y, Kiss Z, Tang V
Appl Neuropsychol Adult. 2021 Mar 15:1-9. doi: 10.1080/23279095.2021.1898396.

Intraluminal Thrombus and Outcomes of Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Treatment

Ding Y, Leng X, Nie X, Pan Y, Li J, Liu D, Yan H, Pu Y, Wei Y, Cai Y, Lu Q, Zhang Z, Duan W, Gu W, Hou X, Yang Z, Wen M, Ma N, Miao Z, Wang Y, Liu L, and on behalf of the RESCUE-RE Study Group
Stroke. 2021;52:1473–1477.

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

McCray BA, Diehl E, Sullivan JM, Aisenberg WH, Zaccor NW, Lau AR, Rich DJ, Goretzki B, Hellmich UA, Lloyd TE, Sumner CJ
Nat Commun. 2021 Mar 4;12(1):1444. doi: 10.1038/s41467-021-21699-y.

Dabigatran or Aspirin in East Asian Patients With Embolic Stroke of Undetermined Source: RE-SPECT ESUS Subgroup Analysis

Uchiyama S, Toyoda K, Lee BC, Liou CW, Wong LKS, Grauer C, Brueckmann M, Taniguchi A, Urano Y, Easton JD; RE-SPECT ESUS Investigators
Stroke. 2021 Mar;52(3):1069-1073. doi: 10.1161/STROKEAHA.120.031891.

High-Degree Middle Cerebral Artery Stenosis : Can Advanced 3D DSA-MRI Fusion Imaging Better Illustrate Plaques and Perforators?

Guan M, Lin J, Huang S, Leng X, Shi C, Qiao H, Wang X, Huang L
Clin Neuroradiol. 2021 Mar;31(1):51-59. doi: 10.1007/s00062-020-00927-w.

Adverse Outcomes Associated With Higher Mean Blood Pressure and Greater Blood Pressure Variability Immediately After Successful Embolectomy in Those With Acute Ischemic Stroke, and the Influence of Pretreatment Collateral Circulation Status

Liu D, Nie X, Pan Y, Yan H, Pu Y, Wei Y, Cai Y, Ding Y, Lu Q, Zhang Z, Gu W, Hou X, Yang Z, Wen M, Wang P, Ma G, Ma N, Miao Z, Leng X, Yan B, Davis SM, Wang Y, Liu L
J Am Heart Assoc. 2021 Feb;10(5):e019350. doi: 10.1161/JAHA.120.019350.

Identifying Biomarkers Associated with Venous Infarction in Acute/Subacute Cerebral Venous Thrombosis

Duan J, Leng X, Han Z, Cai Y, Wang C, Rajah G, Song H, Ding Y, Ji X
Aging Dis. 2021 Feb 1;12(1):93-101. doi: 10.14336/AD.2020.0405.

Effects of wearable ankle robotics for stair and over-ground training on sub-acute stroke: a randomized controlled trial

Yeung LF, Lau CCY, Lai CWK, Soo YOY, Chan ML, Tong RKY
J Neuroeng Rehabil. 2021 Jan 29;18(1):19. doi: 10.1186/s12984-021-00814-6.

Modulation of Functional Connectivity and Low-Frequency Fluctuations After Brain-Computer Interface-Guided Robot Hand Training in Chronic Stroke: A 6-Month Follow-Up Study.

Lau CCY, Yuan K, Wong PCM, Chu WCW, Leung TW, Wong WW, Tong RKY
2021 Jan 20;14:611064. doi: 10.3389/fnhum.2020.611064. . Front Hum Neurosci

Correction: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study

Chan J, Wong A, Yiu B, Mok H, Lam P, Kwan P, Chan A, Mok VCT, Tsoi KKF, Kwok TCY
J Med Internet Res. 2021 Jan 19;23(1):e26724. doi: 10.2196/26724.

Frontotemporal dementia and COVID-19: Hypothesis generation and roadmap for future research

Ng KP, Chiew HJ, Hameed S, Ting SKS, Ng A, Soo SA, Wong BYX, Lim L, Yong ACW, Mok VCT, Rosa-Neto P, Dominguez J, Kim S, Hsiung GYR, Ikeda M, Miller BL, Gauthier S, Kandiah N
Alzheimers Dement (N Y). 2021 Jan 15;6(1):e12085. doi: 10.1002/trc2.12085.

Predictors of survival in frontotemporal lobar degeneration syndromes

El-Wahsh S, Finger EC, Piguet O, Mok V, Rohrer JD, Kiernan MC, Ahmed RM
J Neurol Neurosurg Psychiatry. 2021 Jan 13:jnnp-2020-324349. doi: 10.1136/jnnp-2020-324349.

An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer's disease

Yu Q, Mai Y, Ruan Y, Luo Y, Zhao L, Fang W, Cao Z, Li Y, Liao W, Xiao S, Mok VCT, Shi L, Liu J; National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Neuroimaging Initiative; Frontotemporal Lobar Degeneration Neuroimaging Initiative
Alzheimers Res Ther. 2021 Jan 12;13(1):23. doi: 10.1186/s13195-020-00757-5.

Plaque Wall Distribution Pattern of the Atherosclerotic Middle Cerebral Artery associates with the Circle of Willis Completeness

Li J, Zheng L, Yang WJ, Sze-To CY, Leung TW, Chen XY
Front Neurol. 2021 Jan 11;11:599459. doi: 10.3389/fneur.2020.599459.

Pandemic of the aging society - sporadic cerebral small vessel disease

Lau AYL, Ip BYM, Ko H, Lam BYK, Shi L, Ma KKY, Au LWC, Soo YOY, Leung TWH, Wong A, Mok VCT
Chin Med J (Engl). 2021 Jan 5;134(2):143-150. doi: 10.1097/CM9.0000000000001320.

AD Resemblance Atrophy Index as a Diagnostic Biomarker for Alzheimer's Disease: A Retrospective Clinical and Biological Validation

Mai Y, Yu Q, Zhu F, Luo Y, Liao W, Zhao L, Xu C, Fang W, Ruan Y, Cao Z, Lei M, Au L, Mok VCT, Shi L, Liu J
J Alzheimers Dis. 2021;79(3):1023-1032. doi: 10.3233/JAD-201033.

High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders

Liu C, Zhao L, Fan P, Ko H, Au C, Ng A, Au L, Wong A, Kermode AG, Mok V, Yan Y, Qiu W, Lau AY
J Clin Neurosci. 2021 Jan;83:108-111. doi: 10.1016/j.jocn.2020.11.016.

2020

Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study

Chan JYC, Wong A, Yiu B, Mok H, Lam P, Kwan P, Chan A, Mok VCT, Tsoi KKF, Kwok TCY
J Med Internet Res. 2020 Dec 18;22(12):e17332. doi: 10.2196/17332.

High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders

Liu C, Zhao L, Fan P, Ko H, Au C, Ng A, Au L, Wong A, Kermode AG, Mok V, Yan Y, Qiu W, Lau AY
J Clin Neurosci. . 2020 Dec 11:S0967-5868(20)31639-8. doi: 10.1016/j.jocn.2020.11.016. Online ahead of print.

Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease

Au CKF, Abrigo J, Liu C, Liu W, Lee J, Au LWC, Chan Q, Chen S, Leung EYL, Ho CL, Ko H, Mok VCT, Chen W
J Magn Reson Imaging. 2020 Dec 9. doi: 10.1002/jmri.27464. Online ahead of print.PMID: 33295658.

Teaching Video Neuroimages: A triad of tremor, ataxia and cognitive impairment

Au LWC, Ho K, Li JJX, Mok VCT
Neurology. 2020 Dec 4:10.1212/WNL.0000000000011288. doi: 10.1212/WNL.0000000000011288. Online ahead of print.

Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype

Au LWC, Lee HHC, Sheng B, Chan KY, Yau EKC, Mak CM, Chan AYW, Chan AYY, Lau CKY, Mok VCT, Lam CW
Clin Neurol Neurosurg. 2020 Dec;199:106258. doi: 10.1016/j.clineuro.2020.106258. Epub 2020 Sep 30.PMID: 33031988.

Plaque morphology in acute symptomatic intracranial atheroscleroticdisease

Leung TW, Wang L, Zou X, Soo Y, Pu Y, Ip HL, Chan A, Au LWC, Fan F, Ma SH, Ip B, Ma K, Lau AY, Leung H, Hui KF, Li R, Li SH, Fu M, Fong WC, Liu J, Mok V, Wong KSL, Miao Z, Ma N, Yu SCH, Leng X
J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020- 325027. doi: 10.1136/jnnp-2020-325027.

Effect of microcirculatory resistance on coronary blood flow and instantaneous wave-free ratio: A computational study

Liu H, Ou S, Liu P, Xu Y, Gong Y, Xia L, Leng X, Leung TWH, Shi L, Zheng D
Comput Methods Programs Biomed. 2020 Nov;196:105632. doi: 10.1016/j.cmpb.2020.105632. Epub 2020 Jun 25.

Hong Kong College of Physicians Position Statement and Recommendations on the 2017 American College of Cardiology/American Heart Association and 2018 European Society ofCardiology/European Society of Hypertension Guidelines for Management of Arterial Hypertension

Chan KK, Szeto CC, Lum CCM, Ng PW, Kong APS, Lau KP, Leung JYY, Lui SL, Mo KL, Mok FCK, Mok VCT, Yan BPY, Li PKT
Hong Kong Med J. 2020 Oct;26(5):432-437. doi: 10.12809/hkmj198330.PMID: 33089788.

Rest-Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder

Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MWM, Huang B, Li SX, Chau SWH, Chan JWY, Chen J, Mok VCT, Wing YK, Zhang J
Ann Neurol. 2020 Oct;88(4):817-829. doi: 10.1002/ana.25853. Epub 2020 Aug 18.

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

Lei Zhao, Zhongqi Li, Joaquim S L Vong, Xinyi Chen, Hei-Ming Lai, Leo Y C Yan, Junzhe Huang, Samuel K H Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C T Mok, Ho Ko
Nat Commun. 2020 Sep 4;11(1):4413. doi:10.1038/s41467-020-18249-3.

Nurse Led Smartphone Electrographic Monitoring for Atrial Fibrillation after Ischemic Stroke: SPOT-AF

Yan B, Tu H, Lam C, Swift C, Ma SH, Mok VCT, Sui Y, Sharpe D, Ghia D, Jannes J, Davis S, Liu X, Freedman B
J Stroke. 2020 Sep;22(3):387-395. doi: 10.5853/jos.2020.00689. Epub 2020 Sep 29.PMID: 33053954.

Advanced MRI features in relapsing multiple sclerosis patients with and without CSF oligoclonal IgG bands

Zhao L, Abrigo J, Chen Q, Au C, Ng A, Fan P, Mok V, Qiu W, Kermode AG, Lau AY
Sci Rep. 2020 Aug 13;10(1):13703. doi: 10.1038/s41598-020-70693-9. PMID: 32792656; PMCID: PMC7426866.

Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future

Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath P, GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim SY, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P
Alzheimer's & Dementia. 2020 Aug 12;doi:10.1002/alz.12143

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population

Zhou X, Chen Y, Ip FCF, Lai NCH, Li YYT, Jiang Y, Zhong H, Chen Y, Zhang Y, Ma S, Lo RMN, Cheung K, Tong EPS, Ko H, Shoai M, Mok KY, Hardy J, Mok VCT, Kwok TCY, Fu AKY, Ip NY
Alzheimers Dement (Amst). 2020 Aug 5;12(1):e12074. doi: 10.1002/dad2.12074. eCollection 2020.PMID: 32775599.

Regression of Plaque Enhancement Within Symptomatic Middle Cerebral Artery Atherosclerosis: A High-Resolution MRI Study

Yang WJ, Abrigo J, Soo YO, Wong S, Wong KS, Leung TW, Chu WC, Chen XY.
Front Neurol. 2020 Jul 28;11:755. doi: 10.3389/fneur.2020.00755

High White Matter Hyperintensity Burden in Strategic White Matter Tracts Relates to Worse Global Cognitive Performance in Community-Dwelling Individuals

BIESBROEK JM, LAM BYK, ZHAO L, TANG Y, WANG Z, ABRIGO J, CHU WWC, WONG A, SHI L, KUIJF HJ, BIESSELS GJ, MOK VCT
J Neurol Sci. 2020 Jul 15;414:116835. doi: 10.1016/j.jns.2020.116835. Epub 2020 Apr 13.

Dataset on blood flow and instantaneous wave-free ratio in normal and stenosed coronary arteries

Liu H, Ou S, Liu P, Xu Y, Gong Y, Xia L, Leng X, Leung TWH, Shi L, Zheng D
Data Brief. 2020 Jul 11;32:106011. doi: 10.1016/j.dib.2020.106011. eCollection 2020 Oct.

Impaired Cognition Is Related to Microstructural Integrity in Relapsing Remitting Multiple Sclerosis

ZHAO L, NG A, CHEN Q, LAM B, ABRIGO J, AU C, MOK VCT, WONG A, LAU AY
Ann Clin Transl Neurol. 2020 Jun 9. doi: 10.1002/acn3.51100. Online ahead of print.

Decreased Visible Deep Medullary Veins Is a Novel Imaging Marker for Cerebral Small Vessel Disease

CHEN X, WEI L, WANG J, SHAN Y, CAI W, MEN X, LIU S, KANG Z, LU Z, MOK VCT, WU A
Neurol Sci. 2020 Jun;41(6):1497-1506. doi: 10.1007/s10072-019-04203-9. Epub 2020 Jan 18.

Risk of COVID-19 infection in MS and neuromyelitis optica spectrum disorders

Fan M, Qiu W, Bu B, Xu Y, Yang H, Huang D, Lau AY, Guo J, Zhang MN, Zhang X, Yang CS, Chen J, Zheng P, Liu Q, Zhang C, Shi FD
Neurol Neuroimmunol Neuroinflamm. 2020 Jun 4;7(5):e787. doi: 10.1212/NXI.0000000000000787.

Herb-Drug Interaction of Gastrodiae Rhizoma on Carbamazepine: A Pharmacokinetic Study in Rate

YIP KL, ZHOU X, CHOOK P, LEUNG PC, SCHACHTER S, MOK VCT, LEUNG TWH, KOON CM, LEUNG H
Epilepsy Res. 2020 May 31; 165. doi: 10.1016/j.eplepsyres.2020.106376

Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults

Wong A, Lou W, Ho KF, Yiu BK, Lin S, Chu WC, Abrigo J, Lee D, Lam BY, Au LW, Soo YO, Lau AY, Kwok TC, Leung TW, Lam LC, Ko H, Mok VCT
Sci Rep. 2020 Apr 27;10(1):7090. doi: 10.1038/s41598-020-63568-6.

Translesional Pressure Gradient Alters Relationship Between Blood Pressure and Recurrent Stroke in Intracranial Stenosis

FENG X, CHAN KL, LAN L, ABRIGO J, IP VHL, SOO YOY, LEUNG TW, LENG X
Stroke. 2020 Jun;51(6):1862-1864. doi: 10.1161/STROKEAHA.119.028616. Epub 2020 Apr 21.

Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study

FOO JN, CHEW EGY, CHUNG SJ, PENG R, BLAUWENDRAAT C, NALLS MA, MOK KY, SATAKE W, TODA T, CHAO Y, TAN LCS, TANDIONO M, LIAN MM, NG EY, PRAKASH KM, AU WL, MEAH WY, MOK SQ, ANNUAR AA, CHAN AYY, CHEN L, CHEN Y, JEON BS, JIANG L, LIM JL, LIN JJ, LIU C, MAO C, MOK V, PEI Z, SHANG HF, SHI CH, SONG K, TAN AH, WU YR, XU YM, XU R, YAN Y, YANG J, ZHANG B, KOH WP, LIM SY, KHOR CC, LIU J, TAN EK
JAMA Neurol. 2020 Apr 20;e200428. doi: 10.1001/jamaneurol.2020.0428.

Hemodynamic Significance of Middle Cerebral Artery Stenosis Associated With the Severity of Ipsilateral White Matter Changes

FANG H, LENG X, PU Y, ZOU X, PAN Y, SONG B, SOO YOY, LEUNG TWH, WANG C, ZHAO X, WANG Y, WANG Y, WONG KS, LIU L, XU Y, CICAS STUDY GROUP
Front Neurol. 2020 Apr 15;11:214. doi: 10.3389/fneur.2020.00214. eCollection 2020.

Hemodynamic Significance of Middle Cerebral Artery Stenosis Associated With the Severity of Ipsilateral White Matter Changes

Fang H, Leng X, Pu Y, Zou X, Pan Y, Song B, Soo YOY, Leung TWH, Wang C, Zhao X, Wang Y, Wang Y, Wong KS, Liu L, Xu Y; CICAS Study Group
Front Neurol. 2020 Apr 15;11:214. doi: 10.3389/fneur.2020.00214. eCollection 2020.

Prevalence and Predictors of Mood Disturbances in Idiopathic REM Sleep Behaviour Disorder

CHIU NKH, EHGOETZ MARTENS KA, MOK VCT, LEWIS SJG, MATAR E
J Sleep Res. 2020 Apr 7;e13040. doi: 10.1111/jsr.13040. Online ahead of print.

Stroke Outcome Prediction by Blood Pressure Variability, Heart Rate Variability, and Baroreflex Sensitivity

TANG S, XIONG L, FAN Y, MOK VCT, WONG KS, LEUNG TW
Stroke. 2020 Apr;51(4):1317-1320. doi: 10.1161/STROKEAHA.119.027981. Epub 2020 Jan 22.

Association Between Advanced Interatrial Block and Small Vessel Diseases in the Brain

WANG Z, QIN H, CHEN G, MOK VCT, DAI Y, CAI Y, CHENG X, QIAN Y, CHU M, LU X
Quant Imaging Med Surg. 2020 Mar;10(3):585-591. doi: 10.21037/qims.2020.02.02.

UK Consensus on Pre-Clinical Vascular Cognitive Impairment Functional Outcomes Assessment: Questionnaire and Workshop Proceedings

MCFALL A, HIETAMIES TM, BERNARD A, AIMABLE M, ALLAN SM, BATH PM, BREZZO G, CARARE RO, CARSWELL HV, CLARKSON AN, CURRIE G, FARR TD, FOWLER JH, GOOD M, HAINSWORTH AH, HALL C, HORSBURGH K, KALARIA R, KEHOE P, LAWRENCE C, MACLEOD M, MCCOLL BW, MCNEILLY A, MILLER AA, MINERS S, MOK V, O'SULLIVAN M, PLATT B, SENA ES, SHARP M, STRANGWARD P, SZYMKOWIAK S, TOUYZ RM, TRUEMAN RC, WHITE C, MCCABE C, WORK LM, QUINN TJ
J Cereb Blood Flow Metab. 2020 Mar 9;271678X20910552. doi: 10.1177/0271678X20910552. Online ahead of print.

Contra-Directional Expression of Plasma Superoxide Dismutase With Lipoprotein Cholesterol and High-Sensitivity C-reactive Protein as Important Markers of Parkinson's Disease Severity

YANG W, CHANG Z, QUE R, WENG G, DENG B, WANG T, HUANG Z, XIE F, WEI X, YANG Q, LI M, MA K, ZHOU F, TANG B, MOK VCT, ZHU S, WANG Q.
Front Aging Neurosci. 2020 Mar 6;12:53. doi: 10.3389/fnagi.2020.00053. eCollection 2020.

The Role of Cerebral Microbleeds in the Incidence of Post-Stroke Dementia

YATAWARA C, GUEVARRA AC, NG KP, CHANDER R, LAM BYK, WONG A, MOK V, KANDIAH N
J Neurol Sci. 2020 May 15;412:116736. doi: 10.1016/j.jns.2020.116736. Epub 2020 Feb 15.

Pathophysiology of Vascular Cognitive Impairment (II): Amyloid Contribution in Vascular Cognitive Impairment

KO H, LAM BYK, MOK VCT
Stroke Revisited: Vascular Cognitive Impairment.. 2020;87-97. ISBN 978-981-10-1433-8.

Is the future of symptomatic intracranial atherosclerotic stenosis management promising?

Liu D, Liu J, Cai Y, Wong KSL, Liu L
J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):122- 124. doi: 10.1136/jnnp-2019-321564.

Screening for Chronic Conditions With Reproductive Factors Using a Machine Learning Based Approach

TIAN S, DONG W, CHAN KL, LENG X, BEDFORD LE, LIU J
Sci Rep. 2020 Feb 18;10(1):2848. doi: 10.1038/s41598-020-59825-3.

Protocols of Non-Invasive Brain Stimulation for Neuroplasticity Induction

HE W, FONG PY, LEUNG TWH, HUANG YZ
Neurosci Lett. 2020 Feb 6;719:133437. doi: 10.1016/j.neulet.2018.02.045. Epub 2018 Feb 21.

Pneumocystis Pneumonia in a Patient Treated With Alemtuzumab for Relapsing Multiple Sclerosis

LAU AY, LUI GCY, CHAN KP, AU C, MOK VCT, ZIEMSSEN T
Mult Scler Relat Disord. 2020 Feb;38:101503. doi: 10.1016/j.msard.2019.101503. Epub 2019 Nov 6.

Characteristics of Wall Shear Stress and Pressure of Intracranial Atherosclerosis Analyzed by a Computational Fluid Dynamics Model: A Pilot Study

CHEN Z, QIN H, LIU J, WU B, CHENG Z, JIANG Y, LIU L, JING L, LENG X, JING J, WANG Y, WANG Y
Front Neurol. 2020 Jan 17;10:1372. doi: 10.3389/fneur.2019.01372. eCollection 2019.

Dementia in China: Epidemiology, Clinical Management, and Research Advances

JIA L, QUAN M, FU Y,  ZHAO T, LI Y, WEI C, TANG Y, QIN Q, WANG F, QIAO Y, SHI S, WANG YJ, DU Y, ZHANG J, ZHANG J, LUO B, QU Q, ZHOU C, GAUTHIER S, JIA J, ZHOU A, ZUO X, CHU C, YU Y, CHANG H, LI D, GUO D, XING Y, HUANG X, QIU Q, XU H, YAN X, CHEN S, YANG J, LYU J, JIA Z, HUANG Y, JIA J, PENG D, JI Y, GUO Q, CAO Y, SUN L, LI Y, LYU P, GANG B, ZHANG N, TAN L, TANG H, LI H, LIAO Z, LIU J, LU Y, XU J, ZHANG K, SHI X, JI X, LI X, GUO Y, BI J, MOK VCT, KAN M, LI F, ZHOU W, CHU L, YANG S, YANG H, YOU Y
Lancet Neurol. 2020 Jan;19(1):81-92. doi: 10.1016/S1474-4422(19)30290-X. Epub 2019 Sep 4.

Topological Reorganization of the Default Mode Network in Patients With Poststroke Depressive Symptoms: A Resting-State fMRI Study

LIANG Y, YAO YC, ZHAO L, SHI L, CHEN YK, MOK VC, UNGVARI GS, CHU WC, TANG WK
J Affect Disord. 2020 Jan 1;260:557-568. doi: 10.1016/j.jad.2019.09.051. Epub 2019 Sep 11.

Sustaining Cerebral Perfusion in Intracranial Atherosclerotic Stenosis: The Roles of Antegrade Residual Flow and Leptomeningeal Collateral Flow

LAN L, Leng X, IP V, Soo Y, ABRIGO J, LIU H, FAN F, MA SH, MA K, IP BY, CHAN KL, MOK VC, LIEBESKIND DS, WONG KS, LEUNG TW
J Cereb Blood Flow Metab. 2020 Jan;40(1):126-134. doi: 10.1177/0271678X18805209. Epub 2018 Oct 23.

Development of a Delayed Cerebral Infarction Load Scoring System (DCI Score)

WONG GKC, NUNG RCH, SITT JCM, MOK VCT, WONG A, POON WS, WANG D, ABRIGO J, SIU DYW
Acta Neurochir Suppl. 2020;127:145-148. doi: 10.1007/978-3-030-04615-6_21.

2019

Autoimmune Glial Fibillary Acidic Protein Astrocytopathy Associated Meningoencephalomyelitis and Bilateral Sensorineuronal Deafness

IP B, LAM C, IP V, CHAN A, MOK V, AU E, CHAN E, LAU A
Mult Scler Relat Disord. 2020 May;40:101922. doi: 10.1016/j.msard.2019.101922. Epub 2019 Dec 31.

Neural evidence for long-term marriage shaping the functional brain network organization between couples

Shi L, Lou W, Wong A, Zhang F, Abrigo J, Chu WC, Kwok TC, Wong KK, Abbott D, Wang D, Mok VC.
Neuroimage. 2019 Oct 1;199:87-92. doi: 10.1016/j.neuroimage.2019.05.058. Epub 2019 May 23.

Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study

Yu JT, Li JQ, Suckling J, Feng L, Pan A, Wang YJ, Song B, Zhu SL, Li DH, Wang HF, Tan CC, Dong Q, Tan L, Mok V, Aisen PS, Weiner MM; Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement. 2019 Sep;15(9):1208-1217. doi: 10.1016/j.jalz.2019.05.006. Epub 2019 Aug 6.

Can transcranial Doppler ultrasound be used for screening cerebral small vessel diseases in the community?

Kang D, Wong A, Fu J, Qun X, Liu W, Wang Z, Lin S, Kwan P, Lo E, Au LWC, Ko H, Lau AYL, Leung TWH, Abrigo J, Chu WCW, Mok VCT, Lam BYK.
J Neurol Sci. 2019 Aug 29;406:116439. doi: 10.1016/j.jns.2019.116439. [Epub ahead of print]

Risk estimation before progression to mild cognitive impairment and Alzheimer's disease: an AD resemblance atrophy index.

Zhao L, Luo Y, Lew D, Liu W, Au L, Mok V, Shi L; Alzheimer Disease Neuroimaging Initiative.
Aging (Albany NY). 2019 Aug 29;11(16):6217-6236. doi: 10.18632/aging.102184. Epub 2019 Aug 29.

Physical activities attenuate the negative cognitive impact from white matter hyperintensities in stroke and TIA patients with low education

Wong A, Yiu S, Lam BYK, Leung KT, Shi L, Lo E, Abrigo J, Au LW, Lau A, Mok V.
Int J Geriatr Psychiatry. 2019 Aug 13. doi: 10.1002/gps.5194. [Epub ahead of print]

Souvenaid in the management of mild cognitive impairment: an expert consensus opinion

Cummings J, Passmore P, McGuinness B, Mok V, Chen C, Engelborghs S, Woodward M, Manzano S, Garcia-Ribas G, Cappa S, Bertolucci P, Chu LW.
Alzheimers Res Ther. 2019 Aug 17;11(1):73. doi: 10.1186/s13195-019-0528-6. Review.

Teaching NeuroImages: X-linked adrenoleukodystrophy: Spinocerebellar variant

Au LWC, Chan AYY, Mok VCT.
Neurology. 2019 Aug 13;93(7):e731-e732. doi: 10.1212/WNL.0000000000007958. No abstract available. 

Non-coding variability at the APOE locus contributes to the Alzheimer's risk

Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY.
Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.

Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Wilson D, Ambler G, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sánchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Schrooten M, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Assayag EB, Hallevi H, Tanaka J, Hara H, Coutts SB, Hert L, Polymeris A, Seiffge DJ, Lyrer P, Algra A, Kappelle J, Al-Shahi Salman R, Jäger HR, Lip GYH, Mattle HP, Panos LD, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Kooi ME, van Dam-Nolen DHK, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra C, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, van der Lugt A, Kelly PJ, Wardlaw JM, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network.
Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23.

Effects of Mindfulness Yoga vs Stretching and Resistance Training Exercises on Anxiety and Depression for People With Parkinson Disease: A Randomized Clinical Trial

Kwok JYY, Kwan JCY, Auyeung M, Mok VCT, Lau CKY, Choi KC, Chan HYL.
JAMA Neurol. 2019 Jul 1;76(7):755-763. doi: 10.1001/jamaneurol.2019.0534.

Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker

Abrigo J, Shi L, Luo Y, Chen Q, Chu WCW, Mok VCT; Alzheimer’s Disease Neuroimaging Initiative.
Acta Radiol. 2019 Jun;60(6):769-776. doi: 10.1177/0284185118795327. Epub 2018 Sep 5.

Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis

Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem MA, DeCarli C, Ding D, Gudnason V, Hara H, Imaizumi T, Kohara K, Kwon HM, Launer LJ, Mok V, Phan T, Preis SR, Romero JR, Seshadri S, Srikanth V, Takashima Y, Tsushima Y, Wang Z, Wolf PA, Xiong Y, Yamaguchi S, Werring DJ.
Neurology. 2019 Mar 5;92(10):e1086-e1097. doi: 10.1212/WNL.0000000000007039. Epub 2019 Feb 1.

2018

Comparison of Computerized and Paper-and-Pencil Memory Tests in Detection of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies

Chan JYC, Kwong JSW, Wong A, Kwok TCY, Tsoi KKF.
J Am Med Dir Assoc. 2018 Sep;19(9):748-756.e5. doi: 10.1016/j.jamda.2018.05.010. Epub 2018 Jun 18.

Strategic infarct location for post-stroke cognitive impairment: A multivariate lesion-symptom mapping study

Zhao L, Biesbroek JM, Shi L, Liu W1, Kuijf HJ, Chu WW, Abrigo JM, Lee RK, Leung TW, Lau AY, Biessels GJ, Mok V, Wong A.
J Cereb Blood Flow Metab. 2018 Aug;38(8):1299-1311. doi: 10.1177/0271678X17728162. Epub 2017 Sep 12.

Correlation of non-vitamin K antagonist oral anticoagulant exposure and cerebral microbleeds in Chinese patients with atrial fibrillation

Soo Y, Abrigo J, Leung KT, Liu W, Lam B, Tsang SF, Ip V, Ma K, Ip B, Ma SH, Fan F, Chu W, Wong L, Mok V, Leung TW.
J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):680-686. doi: 10.1136/jnnp-2017-317151. Epub 2018 Mar 29.

Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia

Wong OW, Chan AY, Wong A, Lau CK, Yeung JH, Mok VC, Lam LC, Chan S.
Parkinsonism Relat Disord. 2018 Jul;52:43-48. doi: 10.1016/j.parkreldis.2018.03.013. Epub 2018 Mar 15.

Marriage and risk of dementia: systematic review and meta-analysis of observational studies

Chen PLH, Mok Vincent VCT.
J NEUROL NEUROSURG PSYCHIATRY. 2018 JUL;89(3):231-238. doi: 10.1136/jnnp-2017-316274.

High prevalence and indexes of anti-John Cunningham virus antibodies in a cohort of Chinese patients with multiple sclerosis.

Lau AYL, Qiu W, Kermode A, Au C, Ng A, Wong A, Ma SH, Au L, Ma K, Ip B, Mok VCT.
Mult Scler J Exp Transl Clin. 2018 Jul-Sep; 4(3): 2055217318788699.

The era after DAWN: treatment of acute ischaemic stroke.

Lau KK, Thomas WH Leung TWH, Soo YOY.
Hong Kong Med J . 2018 Jun;24(3):313–5.

Validity and reliability of two alternate versions of the Montreal Cognitive Assessment (Hong Kong version) for screening of Mild Neurocognitive Disorder

Wong A, Yiu S, Nasreddine Z, Leung KT, Lau A, Soo YOY, Wong LKS, Mok VCT.
PLoS ONE. 2018 May;13(5): e0196344

The Additional Contribution of White Matter Hyperintensity Location to Post-stroke Cognitive Impairment: Insights From a Multiple-Lesion Symptom Mapping Study

Zhao L, Wong A, Luo Y, Liu W, Chu WWC, Abrigo JM, Lee RKL, Mok V, Shi L.
Front Neurosci. 2018 May 1;12:290. doi: 10.3389/fnins.2018.00290. eCollection 2018.

Impact of intracranial artery calcification on cerebral hemodynamic changes.

Wu X, Wang L, Zhong J, Ko J, Shi L, Soo Y, Leung T, Wong KS, Abrigo J, Chen X.
Neuroradiology. 2018 Apr;60(4):357-363. doi: 10.1007/s00234-018-1988-2. Epub 2018 Feb 9.

Automatic Segmentation of Acute Ischemic Stroke From DWI Using 3-D Fully Convolutional DenseNets

Zhang RZ, Zhao L, Lou WT, Abrigo JM, Mok VCT, Chu WCW, Wang DF, Lin S.
IEEE Transactions on Medical Imaging. 2018 Mar:37(9):2149-2160.

Association Between the Apolipoprotein E Gene Polymorphism and Atherosclerotic Middle Cerebral Artery Stenosis.

Zhang Z, Chen XY, Baum L, Ng HK, Mok V, Wong KS.
Neurologist. 2018 Mar;23(2):47-50. doi: 10.1097/NRL.0000000000000164.

Converting MMSE to MoCA and MoCA 5-minute protocol in an educationally heterogeneous sample with stroke or transient ischemic attack

Wong A, Black SE, Yiu SYP, Au LWC, Lau AYL, Soo YOY, Chan AYY, Leung TWH1, Wong LKS, Kwok TCY, Cheung TCK, Leung KT, Lam BYK, Kwan JSK, Mok VCT.
Int J Geriatr Psychiatry. 2018 May;33(5):729-734. doi: 10.1002/gps.4846. Epub 2018 Jan 2.

Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study.

Liang Y, Chan YL, Deng M, Chen YK, Mok V, Wang F, Ungvari GS, Chu CW, Tang WK.
J Affect Disord. 2018 Mar 1;228:166-172. doi: 10.1016/j.jad.2017.11.080. Epub 2017 Nov 22.

Cerebral Small Vessel Disease Burden Is Associated With Poststroke Depressive Symptoms: A 15-Month Prospective Study

Liang Y, Chen YK, Mok VCT, Wang DF, Ungvari GS, Chu WCW, Kang HJ, Tang WK.
Front Aging Neurosci. 2018;10:46.

Vascular cognitive impairment

Flier WM, Skoog I, Julie A. Schneider JA, Pantoni L, Mok VCT, Chen CLH, Scheltens P.
Nat Rev Dis Primers. 2018 Feb; 18003.

Antiplatelet therapy after stroke: should it differ in the acute and chronic phase after stroke

Leng X, Leung TW, Wong KSL.
Curr Opin Neurol. 2018 Feb;31(1):14-22. doi: 10.1097/WCO.0000000000000509.

Long-Term Evolutionary Change in the Lumen of Intracranial Atherosclerotic Stenosis Following Angioplasty and Stenting

Yu SCH, Lau TWW, Wong SSM, Lee KT, Wong LKS, Leung TWH.
Oper Neurosurg (Hagerstown). 2018 Feb 1;14(2):128-138. doi: 10.1093/ons/opx097.

Translesional pressure gradient and leptomeningeal collateral status in symptomatic middle cerebral artery stenosis.

Leng X, Lan L, Ip HL, Fan F, Ma SH, Ma K, Liu H, Yan Z, Liu J, Abrigo J, Soo YOY, Liebeskind DS, Wong KS, Leung TW.
Eur J Neurol. 2018 Feb;25(2):404-410. doi: 10.1111/ene.13521. Epub 2017 Dec 18.

Effects of Acupuncture on the Recovery Outcomes of Stroke Survivors with Shoulder Pain: A Systematic Review.

Chau JPC, Lo SHS, Yu X, Choi KC, Lau AYL, Wu JCY, Lee VWY, Cheung WHN, Ching JYL, Thompson DR.
Front Neurol. 2018 Jan 31;9:30. doi: 10.3389/fneur.2018.00030. eCollection 2018.

White Matter Hyperintensity Predicts the Risk of Incident Cognitive Decline in Community Dwelling Elderly

Ding D, Xiong Y, Zhao Q, Guo Q, Chu S, Chu WWC, Luo J, Liang X, Zheng L, Hong Z, Wong LKS, Mok VCT.
J Alzheimers Dis. 2018;61(4):1333-1341. doi: 10.3233/JAD-170876.

Morphological Evolution or Symptomatic Irltracranial A herosclerotic Plaques: a 10-year Longitudinal Study by 3-Dimensional Rotational Angiography

Leng XY, Wang L, Zou XY, Soo YOY, Chan AYY, Ip VHL, Fan FSY, Mok CT, Wong LKS, Yu SCH, Leung TWH.
Stroke. 2018;49:A86.

Morphology of Acute Symptomatic Intracranial Atherosclerotic Plaques

Leng XY, Wang L, Zou XY, Soo YOY, Chan AYY, Ip VHL, Fan FSY, Mok CT, Wong LKS, Yu SCH, Leung TWH.
Stroke. 2018;49:ATP127.

Postmortem Study Exploring Distribution and Patterns of Intracranial Arterial Calcification.

Yang WJ, Zheng L, Wu XH, Niu CB, W Leung TW, Chen XY.
Stroke. 2018;49:AWMP44.

Use of Acupuncture to Reduce Hemiplegic Shoulder Pain is Feasible and Acceptable among Community-Dwelling Stroke Survivors.

Chau JPC, Lo SHS, Lau AYL, Wu JCY, Cheung WHN, Ching JYL, Choi KC, Lee VWY, Sit JWH, Thompson DR.
Stroke. 2018;49:ATP152.

Estimating current and long-term risks of coronary artery in silico by fractional flow reserve, wall shear stress and low-density lipoprotein filtration rate

Haipeng Liu1,2,5, Yinglan Gong3,5, Xinyi Leng1, Ling Xia3, Ka Sing Wong1, Shanxing Ou4, Thomas W Leung1,6, Defeng Wang2 and Lin Shi2,6
Biomedical Physics & Engineering Express. 2018 Jan;4(2).

Preliminary Results of An Observational Study to Evaluate Integrative Medicine in Managing Fatigue and Cognitive Deficits Associated with Multiple Sclerosis

Ng A, Lam M, Au C, Yuen D, Cheung W, Hung Z, Lin WL, Chung V, Wong A, Chan J, Poon S, Poon J, Mok V, Wu J, Lau A.
Mult Scler J. 2018; 402-403.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O7, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM5, Mattsson N7, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ5, Aalten P1, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ; Amyloid Biomarker Study Group, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BNM3, Blennow K, van Buchem MA, Cavedo E, Chen K, Chipi E, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gkatzima O, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Johannsen P, Klimkowicz-Mrowiec A, Köhler S, Koglin N, van Laere K, de Leon M, Lisetti V, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Nordlund A, Novak GP, Paraskevas GP, Perera G, Peters O, Ramakers IHGB, Rami L, Rodríguez-Rodríguez E, Roe CM, Rot U, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE8, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Zetterberg H.
JAMA Psychiatry. 2018 Jan 1;75(1):84-95. doi: 10.1001/jamapsychiatry.2017.3391.

Autonomic Dysfunction Predicts Clinical Outcomes After Acute Ischemic Stroke: A Prospective Observational Study.

Xiong L, Tian G, Leung H, Soo YOY, Chen X, Ip VHL, Mok VCT, Chu WCW, Wong KS, Leung TWH.
Stroke. 2018 Jan;49(1):215-218. doi: 10.1161/STROKEAHA.117.019312. Epub 2017 Dec 4.

Impact of Side Branches on the Computation of Fractional Flow in Intracranial Arterial Stenosis Using the Computational Fluid Dynamics Method.

Liu H, Lan L, Leng X, Ip HL, Leung TWH, Wang D, Wong KS.
J Stroke Cerebrovasc Dis. 2018 Jan;27(1):44-52. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.032. Epub 2017 Oct 27.

2017

Cerebral perfusion difference between hemispheres with symptomatic and asymptomatic intracranial arterial stenosis.

Lan L, Leng X, Abrigo J, Ip V, Soo YO, Leung T, Chen X, Wong KS.
Int J Stroke. 2017 Dec;12(9):NP19-NP20. doi: 10.1177/1747493016676284. Epub 2016 Oct 20.

Brain microbleeds, anticoagulation, and hemorrhage risk: Meta-analysis in stroke patients with AF

Charidimou A, Karayiannis C, Song TJ, Orken DN, Thijs V, Lemmens R, Kim J, Goh SM, Phan TG, Soufan C, Chandra RV, Slater LA, Haji S, Mok V, Horstmann S, Leung KT, Kawamura Y, Sato N, Hasebe N, Saito T, Wong LKS, Soo Y, Veltkamp R, Flemming KD, Imaizumi T, Srikanth V, Heo JH
Neurology. 2017 Dec 5;89(23):2317-2326. doi: 10.1212/WNL.0000000000004704.

Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke

Liang Y, Deng M, Chen YK, Mok V, Wang DF, Ungvari GS, Chu CW, Berge E, Tang WK
CNS Neurosci Ther. 2017 Dec;23(12):973-979. doi: 10.1111/cns.12766.

Minimum Clinically Important Difference of Montreal Cognitive Assessment in aneurysmal subarachnoid hemorrhage patients.

Wong GKC, Mak JSY, Wong A, Zheng VZY, Poon WS, Abrigo J, Mok VCT.
J Clin Neurosci. 2017 Dec;46:41-44. doi: 10.1016/j.jocn.2017.08.039. Epub 2017 Sep 5.

Early versus Late Application of Subthalamic deep brain Stimulation to Parkinson's disease patients with motor complications (ELASS): protocol of a multicentre, prospective and observational study

Jiang L, Poon WS, Moro E, Xian W, Yang C, Zhu XL, Gu J, Cai X, Liu J, Mok V, Liu Y, Xu S, Guo Q, Chen W, Chen L
BMJ Open. 2017 Nov 16;7(11):e018610. doi: 10.1136/bmjopen-2017-018610.

The Spatial Associations of Cerebral Blood Flow and Spontaneous Brain Activities with White Matter Hyperintensities-An Exploratory Study Using Multimodal Magnetic Resonance Imaging.

Shi L, Miao X, Lou W, Liu K, Abrigo J, Wong A, Chu WCW, Wang D, Mok VCT.
Front Neurol. 2017 Nov 9;8:593. doi: 10.3389/fneur.2017.00593. eCollection 2017.

Using Retinal Imaging to Study Dementia

Chan VTT, Tso THK, Tang F, Tham C, Mok V, Chen C, Wong TY, Cheung CY
J Vis Exp. 2017 Nov 6;(129). doi: 10.3791/56137.

Association of Cerebral Small Vessel Disease Burden and Health-Related Quality of Life after Acute Ischemic Stroke.

Liang Y, Chen YK, Deng M, Mok VCT, Wang DF, Ungvari GS, Chu CW, Kamiya A, Tang WK.
Front Aging Neurosci. . 2017 Nov 13;9:372. doi: 10.3389/fnagi.2017.00372. eCollection 2017.

Current status of home blood pressure monitoring in Asia: Statement from the HOPE Asia Network

Chia YC1, Buranakitjaroen P, Chen CH, Divinagracia R, Hoshide S, Park S, Shin J, Siddique S, Sison J, Soenarta AA, Sogunuru GP, Tay JC, Turana Y, Wang JG, Wong L, Zhang Y, Kario K; HOPE Asia Network
J Clin Hypertens (Greenwich). 2017 Nov;19(11):1192-1201. doi: 10.1111/jch.13058. Epub 2017 Aug 17.

Cognitive profiles in Hong Kong Chinese with relapsing and progressive multiple sclerosis.

Lau AY, Ng A, Au C, Yuen KY, Mok V, Wu JC, Wong A.
MULT SCLER J. 2017 Oct; 23:764.

A retrospective, cross sectional controlled study of Chinese medicine for post-stroke rehabilitation.

Ma CH, Li LSW, Kwok LP, Tsang KWY, Cheng MCK, Mok VCT, Or KKH, Zhang ZJ.
J Neurol Sci. 2017 OCT 15;381:923.

Prevalence of neutralising antibodies to interferon-beta and clinical response in Chinese patients with relapsing multiple sclerosis.

Lau AY, Ip WK, Au C, Lau KK, Wong W, Yip KK, Yeung J, Li SH, Li P, Lee R, Siu D, Abrigo J, Wong A, Mok V, Chan E.
Mult Scler J Exp Transl Clin. 2017 Oct 9;3(4):2055217317733485. doi: 10.1177/2055217317733485. eCollection 2017 Oct-Dec.

Noninvasive fractional flow in intracranial atherosclerotic stenosis: Reproducibility, limitations, and perspectives.

Leng X, Lan L, Ip VHL, Liu H, Abrigo J, Liebeskind DS, Wong LKS, Leung TW.
J Neurol Sci. 2017 Oct 15;381:150-152. doi: 10.1016/j.jns.2017.08.3239. Epub 2017 Aug 24.

Smartphone electrographic monitoring for atrial fibrillation in acute ischemic stroke and transient ischemic attack

Tu HT, Chen Z, Swift C, Churilov L, Guo R, Liu X, Jannes J, Mok V, Freedman B, Davis SM, Yan B.
Int J Stroke. 2017 Oct;12(7):786-789. doi: 10.1177/1747493017696097. Epub 2017 Mar 8.

Development and validation of a risk score (CHANGE) for cognitive impairment after ischemic stroke

Chander RJ, Lam BYK, Lin X, Ng AYT, Wong APL, Mok VCT, Kandiah N
Sci Rep. 2017 Sep 29;7(1):12441. doi: 10.1038/s41598-017-12755-z.

Histological Characteristics of Intracranial Atherosclerosis in a Chinese Population: A Postmortem Study.

Yang WJ, Fisher M, Zheng L, Niu CB, Paganini-Hill A, Zhao HL, Xu Y, Wong KS, NG HK, Chen XY.
Front Neurol. 2017;8:488.

Age-specific trends of atrial fibrillation-related ischaemic stroke and transient ischaemic attack, anticoagulant use and risk factor profile in Chinese population: a 15-year study

Soo Y, Chan N, Leung KT, Chen XY, Mok V, Wong L, Leung T
J Neurol Neurosurg Psychiatry. 2017 Sep;88(9):744-748. doi: 10.1136/jnnp-2017-315735.

Recall Tests Are Effective to Detect Mild Cognitive Impairment: A Systematic Review and Meta-analysis of 108 Diagnostic Studies.

Tsoi KKF, Chan JYC, Hirai HW, Wong A, Mok VCT, Lam LCW, Kwok TCY, Wong SYS.
J Am Med Dir Assoc. 2017 Sep 1;18(9):807.e17-807.e29. doi: 10.1016/j.jamda.2017.05.016. Epub 2017 Jul 25.

Intracranial Atherosclerosis: From Microscopy to High-Resolution Magnetic Resonance Imaging.

Yang WJ, Wong KS, Chen XY.
J Stroke. 2017 Sep;19(3):249-260. doi: 10.5853/jos.2016.01956. Epub 2017 Sep 6.

Computerized Cognitive Screen (CoCoSc): A Self-Administered Computerized Test for Screening for Cognitive Impairment in Community Social Centers

Wong A, Fong CH, Mok VC, Leung KT, Tong RK
J Alzheimers Dis. 2017;59(4):1299-1306. doi: 10.3233/JAD-170196.

Using Large-Scale Statistical Chinese Brain Template (Chinese2020) in Popular Neuroimage Analysis Toolkits

Shi L, Liang PP, Luo Y, Liu K, Mok VCT, Chu WCW, Wang DF, Li KC.
Frontiers in Human Neuroscience. 2017;11:6.

Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries

Hilal S1, Mok V, Youn YC, Wong A, Ikram MK5, Chen CL
J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):669-674. doi: 10.1136/jnnp-2016-315324. Epub 2017 Jun 9.

Cortical Microinfarcts in Patients with Middle Cerebral Artery Stenosis.

Leng X, Fang H, Pu Y, Zou X, Pan Y, Soo YOY, Xu Y, Wang C, Zhao X, Wang Y, Wang Y, Liebeskind DS, Wong LKS, Leung TW6, Liu L.
J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1760-1765. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.002. Epub 2017 May 15.

External Counterpulsation Increases Beat-to-Beat Heart Rate Variability in Patients with Ischemic Stroke.

Xiong L1, Tian G, Wang L, Lin W, Chen X, Leung TWH, Soo YOY, Wong LKS.
J Stroke Cerebrovasc Dis. 2017 Jul;26(7):1487-1492. doi: 10.1016/j.jstrokecerebrovasdis.2017.03.007. Epub 2017 Apr 7.

Prediction of Recurrent Stroke or Transient Ischemic Attack After Noncardiogenic Posterior Circulation Ischemic Stroke.

Zhang C, Wang Y, Zhao X, Liu L, Wang C, Pu Y, Zou X, Pan Y, Wong KS, Wang Y; Chinese IntraCranial AtheroSclerosis (CICAS) Study Group.
Stroke. 2017 Jul;48(7):1835-1841. doi: 10.1161/STROKEAHA.116.016285. Epub 2017 Jun 16.

Differences in Characteristics and Outcomes Between Asian and Non-Asian Patients in the TIAregistry.org

Hoshino T, Uchiyama S, Wong LKS, Sissani L, Albers GW, Bornstein NM, Caplan LR, Donnan GA, Ferro JM, Hennerici MG, Labreuche J, Lavallée PC, Molina C, Rothwell PM, Steg PG, Touboul PJ, Vicaut É, Amarenco P; TIAregistry.org Investigators.
Stroke. 2017 Jul;48(7):1779-1787. doi: 10.1161/STROKEAHA.117.016874. Epub 2017 Jun 5.

Impaired cerebral autoregulation: measurement and application to stroke.

Xiong L, Liu X, Shang T, Smielewski P, Donnelly J, Guo ZN, Yang Y, Leung T, Czosnyka M, Zhang R, Liu J, Wong KS.
J Neurol Neurosurg Psychiatry. 2017 Jun;88(6):520-531. doi: 10.1136/jnnp-2016-314385.

A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson's Disease

Ka-Kit Chua, Adrian Wong, Kam-Wa Chan, Yin-Kei Lau, Zhao-Xiang Bian, Jia-Hong Lu, Liang-Feng Liu, Lei-Lei Chen, Ka-Ho Chan, Kim-Pong Tse,1 Anne Chan, Ju-Xian Song, Justin Wu, Li-Xing Zhu, Vincent Mok, and Min Li1
Parkinsons Dis. 2017;2017:1902708.

Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder

Zhou J, Zhang J, Lam SP, Chan JW, Mok V, Chan A, Li SX4, Liu Y, Tang X, Yung WH, Wing YK
Sleep. 2017 May 1;40(5). doi: 10.1093/sleep/zsx041.

Is Dynamic Cerebral Autoregulation Bilaterally Impaired after Unilateral Acute Ischemic Stroke?

Xiong L, Tian G, Lin W, Wang W, Wang L, Leung T, Mok V, Liu J, Chen X, Wong KS
J Stroke Cerebrovasc Dis. 2017 May;26(5):1081-1087. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.024.

Location of Acute Infarcts and Agitation and Aggression in Stroke

Tang WK, Liu XX, Liang H, Chen YK, Chu WCW, Ahuja AT, Abrigo J, Mok VCT, Ungvari GS, Wong KS, Spalletta G
J Neuropsychiatry Clin Neurosci. 2017 Spring;29(2):172-178. doi: 10.1176/appi.neuropsych.15110400.

Neuroticism and Fatigue 3 Months After Ischemic Stroke: A Cross-Sectional Study.

Lau CG, Tang WK, Liu XX, Liang HJ, Liang Y, Mok V, Wong A, Ungvari GS, Kutlubaev MA, Wong KS.
Arch Phys Med Rehabil. 2017 Apr;98(4):716-721. doi: 10.1016/j.apmr.2016.08.480. Epub 2016 Sep 24.

Intracranial atherosclerosis: From anatomy to pathophysiology.

Pu Y, Lan L, Leng X, Wong LK, Liu L.
Int J Stroke. 2017 Apr;12(3):236-245. doi: 10.1177/1747493016685716. Epub 2017 Jan 9.

Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms

Mok VC, Lam BY, Wong A, Ko H, Markus HS, Wong LK
Nat Rev Neurol. 2017 Mar;13(3):148-159. doi: 10.1038/nrneurol.2017.16.

Symptomatic Patients Remain at Substantial Risk of Arterial Disease Complications Before and After Endarterectomy or Stenting.

Hobeanu C, Lavallée PC, Rothwell PM, Sissani L, Albers GW, Bornstein NM, Caplan LR, Donnan GA, Ferro JM, Hennerici MG, Labreuche J, Molina C, Steg PG, Touboul PJ, Uchiyama S, Vicaut É, Wong LK, Amarenco P; TIAregistry.org Investigators.
Stroke. 2017 Apr;48(4):1005-1010. doi: 10.1161/STROKEAHA.116.015171. Epub 2017 Mar 13.

Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects.

Liu K, Zhang T, Chu WC, Mok VC, Wang D, Shi L
Neuroscience. 2017 Mar 6;344:15-24. doi: 10.1016/j.neuroscience.2016.12.026.

Poststroke agitation and aggression and social quality of life: a case control study.

Lau CG, Tang WK, Liu XX, Liang HJ, Liang Y, Wong A, Mok V, Ungvari GS, Wong KS, Kim JS, Paradiso S.
Top Stroke Rehabil. 2017 Mar;24(2):126-133. doi: 10.1080/10749357.2016.1212564. Epub 2016 Sep 7.

Clinical Features of Thalamic Stroke

Chen XY, Wang Q, Wang X, Wong KS
Curr Treat Options Neurol . 2017 Feb;19(2):5. doi: 10.1007/s11940-017-0441-x.

Limb girdle myasthenia with digenic RAPSN and a novel disease gene AK9 mutations

Lam CW, Wong KS, Leung HW, Law CY.
Eur J Hum Genet. 2017 Feb;25(2):192-199. doi: 10.1038/ejhg.2016.162. Epub 2016 Dec 14.

High Extent of Intracranial Carotid Artery Calcification Is Associated with Downstream Microemboli in Stroke Patients.

Wu XH, Chen XY, Fan YH, Leung TW, Wong KS.
J Stroke Cerebrovasc Dis. 2017 Feb;26(2):442-447. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.007. Epub 2016 Nov 3.

Cross-Cultural Differences of the Non-Motor Symptoms Studied by the Traditional Chinese Version of the International Parkinson and Movement Disorder Society- Unified Parkinson's Disease Rating Scale

Yu RL1, Wu RM, Chan AY, Mok V, Wu YR, Tilley BC, Luo S, Wang L, LaPelle NR, Stebbins GT, Goetz CG
Mov Disord Clin Pract. 2017 Jan-Feb;4(1):68-77. doi: 10.1002/mdc3.12349.

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Wang L, Heckman MG, Aasly JO, Annesi G, Bozi M, Chung SJ, Clarke C, Crosiers D, Eckstein G, Garraux G, Hadjigeorgiou GM, Hattori N, Jeon B, Kim YJ, Kubo M, Lesage S, Lin JJ, Lynch T, Lichtner P, Mellick GD, Mok V, Morrison KE, Quattrone A, Satake W, Silburn PA, Stefanis L, Stockton JD, Tan EK, Toda T, Brice A, Van Broeckhoven C, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM, Gasser T, Krüger R, Farrer MJ, Ross OA, Sharma M
Neurobiol Aging. 2017 Jan;49:217.e1-217.e4. doi: 10.1016/j.neurobiolaging.2016.09.022.

Genome-wide association study of Parkinson's disease in East Asians

Foo JN, Tan LC, Irwan ID, Au WL, Low HQ, Prakash KM, Ahmad-Annuar A, Bei J, Chan AY, Chen CM, Chen YC, Chung SJ, Deng H, Lim SY, Mok V, Pang H, Pei Z, Peng R, Shang HF, Song K, Tan AH, Wu YR, Aung T, Cheng CY, Chew FT, Chew SH, Chong SA, Ebstein RP, Lee J, Saw SM, Seow A, Subramaniam M, Tai ES, Vithana EN, Wong TY, Heng KK, Meah WY, Khor CC, Liu H, Zhang F, Liu J, Tan EK
Hum Mol Genet. 2017 Jan 1;26(1):226-232. doi: 10.1093/hmg/ddw379.

Deep Cascaded Networks for Sparsely Distributed Object Detection from Medical Images

Chen, H Dou, Q Yu, L Qin, J Zhao, L Mok, VCT Wang, D Shi, L Heng, PA
Deep Learning for Medical Image Analysis. 2017:(6):133-135.

A 5-Year Longitudinal Study of Cognitive Decline After Stroke/Transient Ischemic Attack (CU-STRIDE).

Lam B, Wong A, Wang ZL, Liu WY, Au L, Chan A, Lau A, Shi L, Fan F, Ma SH, Ip V, Soo Y, Leung T, Leng XY, Chen XY, Chu W, Mok V.
Cerebrovasc Dis. 2017;44(S1):4.

Prolonged Perfusion Predicts Recurrent Ischemic Stroke but not Transient Ischemic Attack in Patients with Symptomatic Intracranial Stenosis.

Lan L, Leng X, Ip V, Leung T, Soo Y, Abrigo J, Wong KS.
Curr Neurovasc Res. 2017;14(2):149-157. doi: 10.2174/1567202614666170413143203.

The prognosis of acute symptomatic seizures after ischaemic stroke.

Leung T, Leung H, Soo YO, Mok VC, Wong KS.
J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):86-94. doi: 10.1136/jnnp-2015-311849. Epub 2016 Jan 27.

Benign Oligemia in Subacute Stage Is Associated with Borderzone Infarction in Stroke Patients Caused by Intracranial Large Artery Disease

Li J, Chen XY, Soo Y, Leung TW, Zeng J, Wong KS.
Eur Neurol. 2017;77(1-2):80-86. doi: 10.1159/000454678. Epub 2016 Dec 14.

Morphometry analysis of basal ganglia structures in children with obstructive sleep apnea.

Lv J, Shi L, Zhao L, Weng J, Mok VC, Chu WC, Wang D.
J Xray Sci Technol. 2017;25(1):93-99. doi: 10.3233/XST-16171.

Sex Differences Do Not Exist in Outcomes among Stroke Patients with Intracranial Atherosclerosis in China: Subgroup Analysis from the Chinese Intracranial Atherosclerosis Study

Pu Y, Wei N, Yu D, Wang Y, Zou X, Soo YOY, Pan Y, Leung TWH, Wong LKS, Wang Y, Liu L.
Neuroepidemiology. 2017;18(1-2):48-54.