People
Dr. Bonnie YK LAM
The Chinese University of Hong Kong
Scientific Officer, Division of Neurology, Department of Medicine & Therapeutics
Academic and Professional Qualifications
PhD (UNSW), BSc (Hons1) (UNSW)Biography
Dr. Bonnie Lam is a Research Assistant Professor at the Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong (CUHK).
She completed a BSc (Advanced, majoring in Neuroscience) at the University of New South Wales (UNSW), Australia. She was awarded her PhD degree (UNSW) and was first to illustrate the patterns of white matter changes in the different clinical subtypes of Frontotemporal Dementia. Dr. Lam was a visiting scholar at the University of Oxford, United Kingdom and the Lugwig Maximillian University of Munich, Germany.
During her post-doctoral training at CUHK, Dr. Lam identified the risk factors for developing delayed-onset poststroke dementia; applied diffusion tensor imaging marker to detect age-related cognitive alterations in community participants; and demonstrated the high global prevalence of cerebral small vessel disease in low- and middle-income countries. Her on-going work includes a multi-center study to investigate how cultural, geographical, and genetic variations may impact the modes of covariation between vascular risk factors and changes in cognition.
To date, Dr. Lam, has published 44 peer-reviewed publications, co-authored in 2 book chapters and obtained 4 grants (Theme-based Research Scheme (T45-407/19N); Health and Medical Research Grant # 3140936, 04153116 & 08190666) as a co-investigator.
Dr. Bonnie YK LAM
The Chinese University of Hong Kong
Scientific Officer, Division of Neurology, Department of Medicine & Therapeutics
Research Interests
- Neuroimaging – with major focus on structural and diffusion imaging with advanced imaging processing techniques and statistical analyses
- Risk factors for cognitive impairment
- Disease groups of investigation:
i) vascular dementia – cerebral small vessel disease;
ii) neurodegenerative diseases; and
iii) poststroke dementia
Awards
- Lee Hysan Postdoctoral Fellowship in Clinical Neurosciences (University of Oxford & CUHK) (2020)
- The Tse Cheuk Ng Tai Prize for Dementia Research (2016)
- Young Investigator Award, VasCog World Meeting (2015)
- Neuroscience Research Australia Scholarship (2011-2014)
- Australian Postgraduate Awards (2010-2014)
- School of Medical Sciences UNSW Travel grant (2013)
- The Postgraduate Research Student Support Scheme (2012)
- Dean’s List for outstanding research, Faculty of Medicine, UNSW(2009)
Selected Publications
- Lam BYK, Cai Y, Akinyemi R, Biessels GJ, van den Brink H, Chen C, Cheung CW, Chow KN, Chung HKH, Duering M, Fu ST, Gustafson D, Hilal S, Hui VMH, Kalaria R, Kim S, Lam MLM, de Leeuw FE, Li ASM, Markus HS, Marseglia A, Zheng H, O'Brien J, Pantoni L, Sachdev PS, Smith EE, Wardlaw J, Mok VCT. The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis. Int J Stroke . 2023 Jan;18(1):15-27.
- Ip BYM*, Lam BYK*, Hui VMH, Au LWC, Liu MWT, Shi L, Lee VWY, Chu WCW, Leung TWH, Ko Ho, Mok VCT. Efficacy and safety of cilostazol in decreasing progression of cerebral white matter hyperintensities-A randomized controlled trial. Alzheimers Dement (N Y) . 2022 Dec 27;8(1):e12369.
- Lam BYK, Yiu B, Ampil E, Chen CLH, Dikot Y, Dominguez J, Ganeshbhai PV, Hilal Saima, Kandiah N, Kim SY, Lee JY, Ong PA, Senanarong V, Leung KT, Wang H, Yang YH, Yong T, Arshad F, Alladi S, Wong S, Ko H, Lau AYK, Mok VCT. High burden of cerebral white matter lesion in 9 Asian cities. Sci Rep. 2021 June:2;11(1):11587:doi: 10.1038/s41598-021-90746-x.
- Ismail M, Mok VCT, Wong A, Au L, Yiu B, Wang Z, Chu WCW, Chan AYY, Fan FSY, Ma SH, Ip V, Ip B, Ma K, Leung H, Soo YOY, Leung TWH, Ko H, Lau AYL, Lam BYK. Risk factors for delayed-onsetdementia after stroke or transient ischemic attack - A 5-year longitudinal cohort study. Int J Stroke . 2022 Jun;17(5):517-525.
- Wong A, Lam BYK*, Mak MKY, Lam LCW, Au LWC, Y BKF, Wong C, Tong HY, Yeung SK, Chu WCW, Shi L, Leung TWH, Soo YOY, Lau AYL, Ip BYM, Kwok TCY, Ko H, Mok VCT. Aerobic Exercise in Older People with Subclinical Sporadic Cerebral Small Vessel Disease – A Randomized Clinical Trial. Alzheimers Dement (N Y) . 2021 Dec 31;7(1):e12224.
- Kang D, Wong A, Fu J, Qun X, Liu W, Wang Z, Lin S, Kwan P, Lo E, Au LWC, Ko H, Lau AYL, Leung TWH, Abrigo J, Chu WCW, Mok VCT, Lam BYK. Can transcranial Doppler ultrasound be used for screening cerebral small vessel diseases in the community? J Neurol Sci . 2019 Nov 15;406:116439.
- Lam BYK, Leung, KT, Yiu B, Zhao L, Biesbroek JM, Au L, Tang Y, Wang K, Fan Y, Fu JH, Song H, Tian X, Chiu WWC, Abrigo J, Shi L, Ko H, Lau A, Duering M, Wong A, Mok VCT. Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors. Alzheimers Dement (Amst) . 2019 Oct 25;11:721-729.
- Mok VCT, Lam BYK, Wong A, Ko H, Markus HS, Wong LKS. Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms. Nature Reviews Neurology. 2017 Mar;13(3):148-159.
- Mok VCT*, Lam BYK*, Wang Z, Liu W, Au L, Leung EYL, Chen S, Yang J, Chu WCW, Lau AYL, Chan AYY, Shi L, Fan F, Ma SH, Ip V, Soo YOY, Leung TWH, Kwok TCY, Ho CL, Wong LKS, Wong A. Delayed-onset dementia after stroke/transient ischemic attack. Alzheimers Dement . 2016 Nov;12(11):1167-1176.
- Lam BYK, Halliday GM, Irish M, Hodges JR, Piguet O. Longitudinal white matter changes in Frontotemporal dementia subtypes. Hum Brain Mapp. 2014 Jul;35(7):3547-57.