有見於現時醫學界對柏金遜綜合症的了解和預防方法都十分有限,香港中文大學醫學院以捐款人張金菱女士之名,成立張金菱治療柏金遜綜合症研究中心,旨在與不同學科聯手研究,發掘可減慢柏金遜綜合症退化的治療及預防方法。

In view of the lacking understanding of and preventive treatments for parkinsonism, the Margaret K.L. Cheung Research Centre for Management of Parkinsonism was established by the Faculty of Medicine, The Chinese University of Hong Kong after the name of the donor, Ms. Margaret Kam Ling Cheung. The Centre is set up with an aim to conduct transdisciplinary research that will enable the discovery of therapeutics that can prevent or slow the progression of common diseases causing parkinsonism.

中大成立張金菱治療柏金遜綜合症研究中心
CUHK Establishes Margaret K.L. Cheung Research Centre for Management of Parkinsonism

我希望此研究中心可以在治療柏金遜綜合症的研究上有所突破,從而惠及這些患者和家庭。

- 捐款人 張金菱女士

I hope the Centre can advance research breakthroughs in the management of parkinsonism to benefit the well-being of patients and families suffering from parkinsonism.

- Ms. Margaret K.L. Cheung, Donor

執行委員會

Executive Board

莫仲棠教授
Prof. Vincent C.T. MOK

高浩醫生
Dr. Owen H. KO

陳然欣醫生
Dr. Anne Y.Y. CHAN

張繼輝博士
Dr. ZHANG Jihui

  • 首席研究員

    Principal Investigators

    Dr. Jill Morales ABRIGO

    香港中文大學醫學院影像及介入放射學系專業顧問

    Professional Consultant

    Department of Imaging and Interventional Radiology

    Faculty of Medicine, The Chinese University of Hong Kong

    陳達明醫生

    Dr. Danny T.M. CHAN

    香港中文大學醫學院外科學系名譽臨床副教授

    Clinical Associate Professor (Honorary)

    Department of Surgery

    Faculty of Medicine, The Chinese University of Hong Kong

    林賢嘉博士

    Dr. Bonnie Y.K. Lam

    香港中文大學醫學院內科及藥物治療學系博士後研究員

    Postdoctoral Fellow

    Department of Medicine and Therapeutics

    Faculty of Medicine, The Chinese University of Hong Kong

    馬家恩醫生

    Dr. Karen K.Y. MA

    香港中文大學醫學院內科及藥物治療學系名譽臨床講師

    Clinical Tutor (Honorary)

    Department of Medicine and Therapeutics

    Faculty of Medicine, The Chinese University of Hong Kong

    石林博士

    Dr. SHI Lin

    香港中文大學醫學院影像及介入放射學系助理教授

    Assistant Professor

    Department of Imaging and Interventional Radiology

    Faculty of Medicine, The Chinese University of Hong Kong

    蘇漢昌博士

    Dr. SO Hon Cheong

    香港中文大學醫學院生物醫學學院助理教授

    Assistant Professor

    School of Biomedical Sciences

    Faculty of Medicine, The Chinese University of Hong Kong

  • 顧問

    Advisors

    榮潤國教授 | 校內顧問

    Prof. WING Yun Kwok | Internal Advisor

    香港中文大學醫學院副院長(學生事務)

    精神科學系系主任

    睡眠檢查室主管

    Associate Dean (Student Affairs), Faculty of Medicine

    Chairman, Department of Psychiatry

    Director of Sleep Assessment Unit

    The Chinese University of Hong Kong

    麥潔儀教授 | 校外顧問

    Prof. Margaret MAK | External Advisor

    香港理工大學醫療及社會科學院副院長

    康復治療科學系物理治療學教授

    Associate Dean, Faculty of Health and Social Sciences

    Professor of Physiotherapy, Department of Rehabilitation Sciences

    The Hong Kong Polytechnic University

    校外顧問

    Prof. Marie-Francoise CHESSELET | External Advisor

    Charles H. Markham Professor of Neurology

    Distinguished Professor, Departments of Neurology and Neurobiology

    David Geffen School of Medicine at UCLA, USA

    校外顧問

    Prof. Michele HU | External Advisor

    Associate Professor, Nuffield Department of Clinical Neurosciences

    Principal Investigator, Oxford Parkinson’s Disease Centre

    University of Oxford, United Kingdom

項目重點

Areas of Focus

分別成立華人早期柏金遜病和腦小血管病登記冊,以了解基因和其他假設的疾病相關因子,從而發展準確的生物標記和診斷方法,並用於預測柏金遜病及腦小血管病的早期病程發展。

Establish two registries for early PD and SVD in Chinese subjects respectively to develop precise biomarkers and diagnostics in understanding genetic and other putative causative factors, as well as to predict and monitor disease progression at the early stage of PD and SVD.

建立特製的活體多光子顯微鏡,結合單細胞基因學技術並用於動物模型,以研究腦小血管病的發病機制。

Build a custom-made in vivo multiphoton microscope combining single-cell genomic techniques for the study of pathogenesis underlying SVD in animal models.

採用嶄新計算方法,結合已知的全基因組關聯分析大數據庫與細胞基因表達模式,將現有的藥物進行虛擬篩選,以找出可用於柏金遜病的藥物。

Employ a novel methodology combining known large databases of genome-wide association study and cellular gene expression patterns to perform virtual screening among large numbers of existing drugs that may help PD.

研究亞洲人獨有的LRRK2 基因變異 (已知最普遍可引致柏金遜病的基因變異) 引致腦神經細胞退化,從而演變成柏金遜綜合症的機制。

Examine the mechanisms of how Asian-specific LRRK2 mutations (the most common genetic mutation known to cause PD) lead to degeneration of nerve cells, resulting in parkinsonism.

研究誘導性多功能幹細胞 (iPSC) 技術於治療柏金遜病的可能性。

Investigate the potential therapeutic properties of iPSC technologies in PD.

發掘可能有效的非藥物治療,例如不同的運動在早期改善柏金遜病的運動和非運動症狀。

Explore potentially effective non-pharmacological treatments, e.g. various exercise training, in improving motor and non-motor symptoms of parkinsonism at an early stage of parkinsonism.

推動與其他研究團隊的協同合作,共同對抗這個挑戰。

Encourage synergistic partnership with other research institutions in tackling the global challenge together.

查詢

Enquiry

Tel. : 2612-1500 / 2895-3968
Email: neurology@cuhk.edu.hk

Copyright© 2019. All rights reserved. The Chinese University of Hong Kong.

查詢

Enquiry

Tel. : 2612-1500 / 2895-3968
Email: neurology@cuhk.edu.hk

Tel. : 2612-1500 / 2895-3968
Email: neurology@cuhk.edu.hk