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Selected Publications

Translational Neuroscience and Neurology

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    Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H, "Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain", Nature Communications, 2020 Sep 4;11(1):4413

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Methods and Tools

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    Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan DCW, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H, "Antibody stabilization for thermally accelerated deep immunostaining", Nature Methods, 2022 Sep;19(9):1137-1146.

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Systems Neuroscience

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    Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H, "An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish", Nature Communications, 2023 Jan 14;14(1):227.

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Methods and Tools

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    Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan DCW, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H, "Antibody stabilization for thermally accelerated deep immunostaining", Nature Methods, 2022 Sep;19(9):1137-1146.

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Translational Neuroscience and Neurology

ChAT_tracts_
    Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H, "Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain", Nature Communications, 2020 Sep 4;11(1):4413

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Systems Neuroscience

ChAT_tracts_
    Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H, "An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish", Nature Communications, 2023 Jan 14;14(1):227.

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Methods and Tools

  1. Yau CN, Lai HM, Lee K, Kwok AJ, Huang J, Ko H, "Principles of deep immunostaining techniques for 3D histology", Cell Reports Methods, 2023 May 22;3:100458.
  2. Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan DCW, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H, "Antibody stabilization for thermally accelerated deep immunostaining", Nature Methods, 2022 Sep;19(9):1137-1146.

Translational Neuroscience and Neurology

  1. Chen X, Zhang J, Li Z, Huang J, Feng C, Vong JSL, Wang Z, Lau SF, Chan DCW, Sy SKH, Yan LYC, Wing YK, Ip BYM, Tang Y, Gu S, Lin WJ, Ng WL, Fu AKY, Ip NY, Ip JPK, Mok VCT, Lai HM, Ko H, "Molecular and functional features of synucleinopathy-associated astrocytes", Manuscript in submission
  2. Kwok AJ, Lu J, Huang J, Ip BY, Mok VCT, Lai HM, Ko H, "High-resolution omics of vascular ageing and inflammatory pathways to neurodegeneration", Seminars in Cell and Developmental Biology, 2023 Jun 26:S1084-9521(23)00131-3
  3. Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H, "Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner", Communications Biology, 2021 Jun 2;4(1)656
  4. Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H, "Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain", Nature Communications, 2020 Sep 4;11(1):4413
  5. Ko H, Lam BYK, Mok VCT, “Pathophysiology of vascular cognitive impairment (II): amyloid contribution in vascular cognitive impairment”, Invited book chapter in Stroke Revisited: Vascular Cognitive Impairment, Springer Press, 2020 Feb 11; 87-97
  6. Mok VCT, Lam BYK, Wong A, Ko H, Markus HS, Wong LKS, “Early- and delayed-onset poststroke dementia – a revisit of the mechanisms”, Nature Reviews Neurology, 2017 Mar;13(3):148-159

Systems Neuroscience

  1. Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H, "An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish", Nature Communications, 2023 Jan 14;14(1):227.
  2. Li Q*, Ko H*, Qian ZM, Yan LYC, Chan DCW, Arbuthnott GW, Ke Y, Yung WH, “Refinement of learned skilled movement representation in motor cortex deep output layer”, Nature Communications, 2017 Jun 9;8:15834.
  3. Huang Y, Yoon K, Ko H, Jiao S, Ito W, Wu JY, Yung WH, Lu B, Morozov A, “5-HT3a receptors modulate hippocampal gamma oscillations by regulating synchrony of parvalbumin-positive interneurons”, Cerebral Cortex, 2016 Feb;26(2):576-85.
  4. Okun M, Steinmetz N, Cossell L, Iacaruso MF, Ko H, Barthó P, Moore T, Hofer SB, Mrsic-Flogel TD, Carandini M, Harris KD, “Diverse coupling of neurons to populations in sensory cortex”, Nature, 2015 May 28;521(7553):511-5.
  5. Cossell L, Iacaruso MF, Muir DR, Houlton R, Sader EN, Ko H, Hofer SB, Mrsic-Flogel TD, “Functional organization of excitatory synaptic strength in primary visual cortex”, Nature, 2015 Feb 19;518(7539):399-403.
  6. Ko H, “Functional organization of synaptic connectivity in the neocortex”, Runner-up essay, Eppendorf and Science Prize for Neurobiology 2014, Science, 2014 Oct 31; 346(6209):555.
  7. Ko H, Mrsic-Flogel TD, Hofer SB, “Emergence of feature-specific connectivity in cortical microcircuits in the absence of visual experience”, The Journal of Neuroscience, 2014 Jul 16;34(29):9812-6.
  8. Ko H, Cossell L, Baragli C, Antolik J, Clopath C, Hofer SB, Mrsic-Flogel TD, “The emergence of functional microcircuits in visual cortex”, Nature, 2013 Apr 4;496(7443):96-100.
  9. Li Q, Ke Y, Chan DCW, Qian ZM, Yung KKL, Ko H, Arbuthnott GW, Yung WH, “Therapeutic deep brain stimulation in parkinsonian rats directly influences motor cortex”, Neuron, 2012 Dec 6;76(5):1030-41.
  10. Hofer SB*, Ko Ho*, Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD, “Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex”, Nature Neuroscience, 2011 Jul 17;14(8):1045-52.
  11. Ko H, Hofer SB, Pichler B, Buchanan KA, Sjöström PJ, Mrsic-Flogel TD, “Functional specificity of local synaptic connections in neocortical networks”, Nature, 2011 May 5;473(7345):87-91.

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