People
Dr. Cindy XY LENG
The Chinese University of Hong Kong
Assistant Professor, Department of Medicine & Therapeutics
Academic and Professional Qualifications
BMed, MMed, PhD, FAHABiography
Dr. Leng's research focuses on stroke and intracranial atherosclerotic disease (ICAD). In the past few years, Dr. Leng has been utilizing multimodal neuroimaging and computational methods to study cerebral hemodynamics and plaque characteristics in ICAD and its clinical implications, using a cross-disciplinary approach. She also works on the efficacy and safety of medical and interventional treatment regimens in ischemic stroke, and investigates mechanisms of collateral circulation recruitment and its prognostic values in stroke patients. In these research areas, she has close collaboration with University of Oxford, University of California Los Angeles, Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, and Beijing Tiantan Hospital of Capital Medical University.
Dr. Leng has been funded by the Research Grants Council of Hong Kong, Health and Medical Research Fund, the National Natural Science Foundation of China, China Association for Science and Technology, and the Lee Hysan Foundation. Since 2013, Dr. Leng has published more than 110 peer-reviewed articles in international academic journals, including Circulation, Ann Neurol, Neurology, J Neurol Neurosurg Psychiatry, Stroke, etc.
Dr. Cindy XY LENG
The Chinese University of Hong Kong
Assistant Professor, Department of Medicine & Therapeutics
Research Interests
- Imaging, treatment and prognosis of ischemic stroke and intracranial atherosclerotic disease
- Cerebral hemodynamics and plaque characteristics in intracranial atherosclerotic disease
- Collateral circulation in ischemic stroke and intracranial atherosclerotic disease
Honorary Appointments in Other Professional Activities
- Assistant Editor, Stroke and Vascular Neurology
- Editorial Board Member, Stroke
- Editorial Board Member, International Journal of Stroke
- Editorial Board Member, European Stroke Journal
Awards
- Top Reviewer Award, International Journal of Stroke, Official Journal of World Stroke Organization (2022, 2024)
- Outstanding Editor Award, Stroke and Vascular Neurology, Official Journal of Chinese Stroke Association (2024)
- Outstanding Researcher of the Chinese Stroke Association (2021)
- Outstanding Researcher of the Chinese Stroke Association (2020)
- Lee Hysan Postdoctoral Fellowship in Clinical Neurosciences (2018)
- World Heart Federation Emerging Leaders (2018)
- Young Elite Scientist, China Association for Science and Technology (2017)
Selected Publications
- Leng X, Nie X, Yan H, Pan Y, Zheng L, Liu Y, Duan W, Liu X, Wei Y, Gu W, Hou X, Leung TW, Miao Z, Liebeskind DS, Liu L (corresponding author). Collaterals and outcomes after endovascular treatment in acute large vessel occlusion: Disparity by stroke etiologies. Int J Stroke. Published online on 16 Feb 2025.
- Zheng L, Nie X, Wang M, Liu X, Duan W, Zhang Z, Liu J, Wei Y, Wen M, Yang Z, Leung TW, Ma G, Huo X, Pan Y, Nguyen TN, Leng X (corresponding author) , Miao Z (corresponding author), Liu L (corresponding author), for ANGEL-ASPECT Investigators. Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial. eClinicalMedicine. 2024;72:102595.
- Leng X, Hurford R, Feng X, Chan KL, Wolters FJ, Li L, Soo YOY, Mok VCT, Leung TW, Rothwell PM (corresponding author). Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: two contemporaneous cohorts and a systematic review. J Neurol Neurosurg Psychiatry. 2021;92:590-597.
- Leung TW, Wang L, Zou X, Soo Y, Pu Y, Ip HL, Chan A, Au LWC, Fan F, Ma SH, Ip B, Ma K, Lau AY, Leung H, Hui KF, Li R, Li SH, Fu M, Fong WC, Liu J, Mok V, Wong KSL, Miao Z, Ma N, Yu SCH (corresponding author), Leng X (corresponding author) . Plaque morphology in acute symptomatic intracranial atherosclerotic disease. J Neurol Neurosurg Psychiatry. 2021;92:370-376.
- Lan L, Liu H (co-1st author), Ip V, Soo Y, Abrigo J, Fan F, Ma SH, Ma K, Ip BYM, Liu J, Fan Y, Zeng J, Mok VCT, Wong KS, Liebeskind DS, Leung TW (corresponding author), Leng X (corresponding author) . Regional high wall shear stress associated with regression of luminal stenosis in symptomatic intracranial atherosclerotic disease. Stroke. 2020;51:3064-3073.
- Feng X, Chan KL, Lan L, Abrigo J, Ip VHL, Soo Y, Leung TW, Leng X (corresponding author) . Translesional pressure gradient alters relationship between blood pressure and recurrent stroke in intracranial stenosis. Stroke. 2020; 51:1862-1864.
- Feng X, Chan KL, Lan L, Abrigo J, Fang H, Xu Y, Soo Y, Leng X (corresponding author) , Leung TW (corresponding author). Stroke mechanisms in symptomatic intracranial atherosclerotic disease: classification and clinical implications. Stroke. 2019;50:2692-2699.
- Leng X (corresponding author) , Lan L (co-1st author), Ip HL, Abrigo J, Scalzo F, Liu H, Feng X, Chan KL, Fan FS, Ma SH, Fang H, Xu Y, Li J, Zhang B, Xu Y, Soo YO, Mok VC, Yu SC, Liebeskind DS, Wong KS, Leung TW (corresponding author). Hemodynamics and stroke risk in intracranial atherosclerotic disease. Ann Neurol. 2019;85:752-764.
- Leng X, Fang H, Leung TWH, Mao C, Miao Z, Liu L, Wong KS, Liebeskind DS (corresponding author). Impact of collaterals on the efficacy and safety of endovascular treatment in acute ischemic stroke: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016;87:537-544.
- Leng X, Wong KS, Liebeskind DS (corresponding author). Evaluating intracranial atherosclerosis rather than intracranial stenosis. Stroke. 2014;45: 645-651.